Patents by Inventor Bernard Smith

Bernard Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral nucleoside derivatives
    Patent number: 6846810
    Abstract: The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula I, pharmaceutical compositions comprising these compounds and methods for treatment or prophylaxis of Hepatitis C Virus mediated diseases employing said compounds in monotherapy or in combination therapy.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: January 25, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: Joseph Armstrong Martin, Keshab Sarma, David Bernard Smith, Mark Smith
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Publication number: 20040266782
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) 1
    Type: Application
    Filed: November 21, 2003
    Publication date: December 30, 2004
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6770650
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: August 3, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Donald Roy Hirschfeld, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Indole nitriles
    Patent number: 6759428
    Abstract: Compounds of the formula (I) wherein m, n, R1, R2, R3, R4, R5 and R6 are as described herein, together with methods for making the compounds and using the compounds for treatment of diseases or conditions mediated by Cathepsin K.
    Type: Grant
    Filed: June 2, 2003
    Date of Patent: July 6, 2004
    Assignee: Roche Palo Alto LLC
    Inventors: Joe Timothy Bamberg, Tobias Gabriel, Nancy Elisabeth Krauss, Taraneh Mirzadegan, Wylie Solang Palmer, David Bernard Smith
  • Antiviral nucleoside derivatives
    Publication number: 20040121980
    Abstract: The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula I, pharmaceutical compositions comprising these compounds and methods for treatment or prophylaxis of Hepatitis C Virus mediated diseases employing said compounds in monotherapy or in combination therapy.
    Type: Application
    Filed: November 19, 2003
    Publication date: June 24, 2004
    Applicant: Roche Palo Alto LLC
    Inventors: Joseph Armstrong Martin, Keshab Sarma, David Bernard Smith, Mark Smith
  • Heteroaryl nitriles
    Patent number: 6747053
    Abstract: The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5 and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment of diseases which are associated with cysteine proteases such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: June 8, 2004
    Assignee: Roche Palo Alto LLC
    Inventors: Tobias Gabriel, Nancy Elisabeth Krauss, Taraneh Mirzadegan, Wylie Solang Palmer, David Bernard Smith
  • Indole nitriles
    Publication number: 20040077646
    Abstract: Compounds of the formula (I) 1
    Type: Application
    Filed: June 2, 2003
    Publication date: April 22, 2004
    Inventors: Joe Timothy Bamberg, Tobias Gabriel, Nancy Elisabeth Krauss, Taraneh Mirzadegan, Wylie Solang Palmer, David Bernard Smith
  • Synthesis of purine derivatives
    Publication number: 20040034224
    Abstract: The present invention provides a method for producing highly substituted purine compounds from pyrimidine compounds. Furthermore, methods of the present invention allow preparation of a library of purine compounds.
    Type: Application
    Filed: June 27, 2003
    Publication date: February 19, 2004
    Applicant: Roche Palo Alto LLC
    Inventors: Lars G.J. Hammarstrom, Nancy Elisabth Krauss, Sharada Shenvi Labadie, David Bernard Smith, Francisco Xavier Talamas
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6683074
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: January 27, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Piperidine CCR-3 receptor antagonists
    Publication number: 20030229121
    Abstract: The invention provides compounds of Formula (I): 1
    Type: Application
    Filed: November 29, 2002
    Publication date: December 11, 2003
    Applicant: Syntex (U.S.A.) LLC
    Inventors: Daisy Joe Du Bois, Denis John Kertesz, Eric Brian Sjogren, David Bernard Smith, Beihan Wang
  • Heteroaryl nitriles
    Publication number: 20030212097
    Abstract: The present invention relates to compound of formula (I) 1
    Type: Application
    Filed: December 3, 2002
    Publication date: November 13, 2003
    Inventors: Tobias Gabriel, Nancy Elisabeth Krauss, Taraneh Mirzadegan, Wylie Solang Palmer, David Bernard Smith
  • Piperazine CCR-3 receptor antagonists
    Publication number: 20030176441
    Abstract: The invention provides compounds of Formula (I): 1
    Type: Application
    Filed: November 29, 2002
    Publication date: September 18, 2003
    Inventors: Daisy Joe Du Bois, Denis John Kertesz, Eric Brian Sjogren, David Bernard Smith, Beihan Wang
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Publication number: 20030153577
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) 1
    Type: Application
    Filed: August 29, 2001
    Publication date: August 14, 2003
    Applicant: Roche Bioscience
    Inventors: Leyi Gong, Donald Roy Hirschfeld, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • 8-Aza-11-deoxy prostaglandin analogues
    Publication number: 20030120079
    Abstract: This invention relates to compounds which are generally EP4 receptor agonists and which are represented by Formula I: 1
    Type: Application
    Filed: July 16, 2002
    Publication date: June 26, 2003
    Inventors: Todd Richard Elworthy, Tara Mirzadegan, Michael Garret Roepel, David Bernard Smith, Keith Adrian Walker
  • 2-pyrrolidone derivatives as prostanoid agonists
    Publication number: 20030064964
    Abstract: This invention relates to 8-aza prostanoid analogs which are generally EP4 receptor agonists and are represented by Formula I: 1
    Type: Application
    Filed: July 16, 2002
    Publication date: April 3, 2003
    Inventors: Todd Richard Elworthy, Michael Garret Roepel, David Bernard Smith
  • Benzofuran and benzothiophene derivatives as anti-inflammatory agents
    Patent number: 6433005
    Abstract: This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —C(O)—, —O—, —S—, —S(O)—, or —S(O)2— and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: August 13, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Kevin L. McLaren, David Bernard Smith, Jahari Laurant Tracy
  • Wheel
    Patent number: D497584
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: October 26, 2004
    Assignee: Pacific Coast Wheel Factory, Inc.
    Inventors: Bernard Smith, Kirk A. Hoeppner
  • Wheel
    Patent number: D497585
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: October 26, 2004
    Assignee: Pacific Coast Wheel Factory, Inc.
    Inventors: Bernard Smith, Kirk A. Hoeppner
  • Wheel
    Patent number: D498449
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: November 16, 2004
    Assignee: Pacific Coast Wheel Factory, Inc.
    Inventors: Bernard Smith, Kirk A. Hoeppner
  • Wheel
    Patent number: D498722
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: November 23, 2004
    Assignee: Pacific Coast Wheel Factory, Inc.
    Inventors: Bernard Smith, Kirk A. Hoeppner