Patents by Inventor Bernard V. Franko

Bernard V. Franko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof in a method of counteracting histamine
    Patent number: 4604388
    Abstract: A method of counteracting the effects of histamine with aromatic azepinones and diazepinones and thiones thereof having the formula ##STR1## wherein: A is benzene, naphthalene, quinoline or pyridine;B is oxygen or sulfur:E is oxygen, sulfur or loweralkyl substituted nitrogen;n is 1, 2 or 3;Z is an amino or a heterocyclic nitrogen containing radical;R is hydrogen, loweralkyl, cycloalkyl or phenyl-loweralkyl;and compositions therefor are disclosed.
    Type: Grant
    Filed: July 9, 1985
    Date of Patent: August 5, 1986
    Assignee: A. H. Robins Company, Incorporated
    Inventors: Charles A. Leonard, Bernard V. Franko, Albert D. Cale, Jr.
  • Method for increasing coronary blood flow in mammals
    Patent number: 4163790
    Abstract: Compounds of the following general formula are useful for increasing coronary blood flow in mammals: ##STR1## wherein R is hydrogen, acetyl, p-fluorobenzoylpropyl, carbamoyl, N-methylcarbamoyl, N,N-dimethylcarbamoyl, phenylcarbamoyl, or N-(.omega.-morpholinoethyl)carbamoyl; R.sup.1 is hydrogen; R.sup.2 is hydrogen or hydroxy; or R.sup.1 and R.sup.2 taken together form a second bond between the carbon atoms bearing R.sup.1 and R.sup.2 ; R.sup.3 is hydrogen or fluorine and pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: March 14, 1978
    Date of Patent: August 7, 1979
    Assignee: A. H. Robins Company, Inc.
    Inventors: Bernard V. Franko, Anthony G. Proakis