Patents by Inventor Bernard Weisblum

Bernard Weisblum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6824994
    Abstract: Disclosed herein are methods for exposing a cell to a peptide so as to inhibit binding in a two-component signal transduction system. Such methods can control the development of antibiotic resistance in pathogenic bacteria and other hosts. Peptides useful in such methods, and methods for identifying such peptides, are also disclosed.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: November 30, 2004
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bernard Weisblum, Andrew T. Ulijasz
  • Publication number: 20040077828
    Abstract: This disclosure relates to a peptide motif and proteins containing the motif that are capable of binding to secreted Frizzled-related protein family members. Accordingly, the disclosure also includes methods of regulating the interaction of sFRP-1 with proteins containing the motif.
    Type: Application
    Filed: July 10, 2003
    Publication date: April 22, 2004
    Inventors: Jeffrey S. Rubin, Aykut Uren, Brian K. Kay, Bernard Weisblum, Matthew Todd Gillespie, Nicole Joy Horwood
  • Publication number: 20040033534
    Abstract: Disclosed herein are methods for exposing a cell to a peptide so as to inhibit binding in a two-component signal transduction system. Such methods can control the development of antibiotic resistance in pathogenic bacteria and other hosts. Peptides useful in such methods, and methods for identifying such peptides, are also disclosed.
    Type: Application
    Filed: August 2, 2002
    Publication date: February 19, 2004
    Inventors: Bernard Weisblum, Andrew T Ulijasz
  • Patent number: 6683154
    Abstract: Disclosed are antimicrobial compositions containing &bgr;-peptides and methods of inhibiting microbial growth in mammals using the compositions. The &bgr;-peptides present in the compositions contain ring structures in the peptide backbone which limit the conformational flexibility of the peptide backbone.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: January 27, 2004
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Samuel Helmer Gellman, Bernard Weisblum, Emilie Ann Porter, Xifang Wang
  • Publication number: 20030100127
    Abstract: Disclosed are methods for making surface plasmon resonance-capable arrays wherein molecules, such as proteins or nucleic acids, or cells, are adhered to a metal substrate. The metal substrates are modified by depositing an &ohgr;-modified alkanethiol monolayer to the substrate and then contacting the &ohgr;-modified monolayer with a heterobifunctional linking compound. Biomolecules or cells can then be attached to the heterobifunctional linking compound. Also disclosed are arrays wherein glutathione-containing molecules are immobilized on the substrate and GST-containing molecules are then specifically immobilized onto the substrate, taking advantage of the affinity between glutathione and GST.
    Type: Application
    Filed: March 15, 2002
    Publication date: May 29, 2003
    Inventors: Robert M. Corn, Emily A. Smith, Bernard Weisblum, Matthew G. Erickson, Andrew T. Ulijasz, Matthew J. Wanat
  • Patent number: 4529695
    Abstract: A process for producing organic compounds from an organism is disclosed, together with a recombinant cloning vector and host useful therewith. The invention appears to be most suitable for producing organisms whose growth is inhibited by the product which they produce. In one embodiment of the process, a recombinant cloning vector is prepared which has a gene determinant for the organic compound and an antibiotically inducible control region. The gene determinant is subjected to the control of the control region such that production of the organic compound is inhibited prior to induction. After insertion of the recombinant cloning vector into the host organism, the host is grown to a desired density. Thereafter, production is induced by adding an inducing antibiotic to the host.
    Type: Grant
    Filed: October 6, 1982
    Date of Patent: July 16, 1985
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Bernard Weisblum
  • Patent number: 4376823
    Abstract: A method of increasing the yield of a desired product, such as an antibiotic, by an organism which normally must first become inducibly resistant to that product before it can produce the product in maximum yields comprises producing constitutively resistant cells of the organism by supplementing a culture of the organism with an agent in which only cells able to specifically modify the 23S ribosomal RNA constitutively, rather than inducibly, survive thereby producing an organism in which the resistance to the product is expressed without the need for activation by the induction process; followed by purification and utilization of that organism for increased product production.
    Type: Grant
    Filed: June 18, 1981
    Date of Patent: March 15, 1983
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Bernard Weisblum