Patents by Inventor Bernard Ziegler

Bernard Ziegler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9932307
    Abstract: Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: April 3, 2018
    Assignee: Pfizer Inc.
    Inventors: Renuka Devi Reddy, Evgenyi Shalaev, Ravi Mysore Shanker, Carl Bernard Ziegler
  • Publication number: 20160332965
    Abstract: Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.
    Type: Application
    Filed: July 27, 2016
    Publication date: November 17, 2016
    Inventors: Renuka Devi Reddy, Evgenyi Shalaev, Ravi Mysore Shanker, Carl Bernard Ziegler
  • Patent number: 9428455
    Abstract: Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: August 30, 2016
    Assignee: Pfizer Inc.
    Inventors: Renuka Devi Reddy, Evgenyi Shalaev, Ravi Mysore Shanker, Carl Bernard Ziegler
  • Publication number: 20150274659
    Abstract: Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.
    Type: Application
    Filed: April 16, 2015
    Publication date: October 1, 2015
    Inventors: Renuka Devi Reddy, Evgenyi Shalaev, Ravi Mysore Shanker, Carl Bernard Ziegler
  • Patent number: 9056831
    Abstract: A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
    Type: Grant
    Filed: February 8, 2014
    Date of Patent: June 16, 2015
    Assignee: Pfizer Inc.
    Inventors: Antone John deBettencourt, III, Peter Robert Rose, Evgenyi Shalaev, George Joseph Quallich, Carl Bernard Ziegler
  • Publication number: 20140155627
    Abstract: A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
    Type: Application
    Filed: February 8, 2014
    Publication date: June 5, 2014
    Applicant: Pfizer Inc.
    Inventors: Antone John deBettencourt, III, Peter Robert Rose, Evgenyi Shalaev, George Joseph Quallich, Carl Bernard Ziegler
  • Publication number: 20120328360
    Abstract: A method for non-releasable fixing of at least one component to a further component is provided in which a hot rivet is introduced into an opening of the at least one first component and an end face of a shank of the hot rivet is welded to a surface of the further component. Subsequently, with plastic deformation of the hot rivet, the shank of the hot rivet is compressed until a head of the hot rivet lies with a pre-stressing force at least in areas on a surface of the at least one component. The pre-stressing force, with which the head of the hot rivet lies at least in areas on the surface of the at least one component, is adjusted to a predefined value.
    Type: Application
    Filed: December 9, 2010
    Publication date: December 27, 2012
    Applicant: Daimler AG
    Inventors: Bernd Koppitz, Rudolf Reinhardt, Tobias Schuster, Heiko Steinmetz, Bernard Ziegler
  • Publication number: 20110086086
    Abstract: The invention provides transdermal compositions comprising varenicline or its pharmaceutically acceptable salt or prodrug form.
    Type: Application
    Filed: June 13, 2006
    Publication date: April 14, 2011
    Inventors: Barbara Alice Johnson, Carl Bernard Ziegler
  • Publication number: 20080269314
    Abstract: A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
    Type: Application
    Filed: October 12, 2005
    Publication date: October 30, 2008
    Inventors: Antone John Debetten-Court, Peter Robert Rose, Evgenyi Yur'evich Shalaev, George Joseph Quallich, Carl Bernard Ziegler
  • Publication number: 20080181933
    Abstract: A chewing gum composition including a water insoluble base portion; a water soluble portion; and a therapeutically effective amount of varenicline or its pharmaceutical acceptable salt thereof. A method for reducing nicotine addiction and aiding in the cessation or lessening of tobacco use in an individual by administering to an oral cavity of an individual a chewing gum composition including an effective amount of varenicline or its pharmaceutical acceptable salt thereof; and chewing the gum composition to cause the varenicline or its pharmaceutical acceptable salt thereof to be released from the chewing gum composition into the oral cavity of the individual. A method of manufacturing a chewing gum composition.
    Type: Application
    Filed: March 9, 2006
    Publication date: July 31, 2008
    Inventors: Barbara Alice Johnson, Carl Bernard Ziegler
  • Patent number: 5750735
    Abstract: Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri-substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, processes for preparing the compounds and new intermediates useful in the process.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: May 12, 1998
    Assignee: American Cyanamid Company
    Inventors: Yang-I Lin, Panayota Bitha, Subas Sakya, Timothy W. Strohmeyer, Karen Bush, Carl Bernard Ziegler, Gregg Brian Feigelson
  • Patent number: 5744465
    Abstract: Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, method of inhibiting a Beta-lactamase enzyme by administering said compounds, processes for preparing the compounds and new intermediates useful in the process are disclosed.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: April 28, 1998
    Assignee: American Cyanamid Company
    Inventors: Yang-I Lin, Panayota Bitha, Subas Sakya, Timothy W. Strohmeyer, Karen Bush, Carl Bernard Ziegler, Gregg Brian Feigelson
  • Patent number: 5700930
    Abstract: New 4-substituted azetidinones having the formulae I and II: ##STR1## wherein X is oxygen, sulfur or a moiety of the formula NR.sup.6 where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined hereafter, which are intermediates for the preparation of carbapenem and carbacephem antibacterials and processes for producing such antibacterials through the utilization of an acid mediated ring closure reaction.
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: December 23, 1997
    Assignee: American Cyanamid Company
    Inventors: Gregg Brian Feigelson, William V. Curran, Carl Bernard Ziegler
  • Patent number: 5656753
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.12, R.sup.16 and R.sup.17 are defined in the specification are provided. These compounds are useful as intermediates for the preparation of carbapenem antibacterials.
    Type: Grant
    Filed: August 24, 1994
    Date of Patent: August 12, 1997
    Assignee: American Cyanamid Company
    Inventors: Gregg Brian Feigelson, William V. Curran, Carl Bernard Ziegler
  • Patent number: 4744532
    Abstract: Flight control system for aircraft of the type provided with ailerons, elevators, upper surface spoilers, and upper surface air-brakes, a rudder and horizontal stabilizers with variable angle of incidence, said system comprising an electric control, in some cases without any mechanical emergency control for said upper surface spoilers and air-brakes.According to the invention:the ailerons and elevators are electrically controlled without any mechanical aid,the rudder is mechanically controlled, andthe horizontal stabilizers with variable angle of incidence are electrically controlled with mechanical aid.the electrical flight controls are optimized.
    Type: Grant
    Filed: September 1, 1987
    Date of Patent: May 17, 1988
    Assignee: Societe Nationale Industrielle et Aerospatiale
    Inventors: Bernard Ziegler, Michel Durandeau, Thierry Collard