Patents by Inventor Bernardino Ghetti

Bernardino Ghetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ferritin light subunit variant-encoding nucleic acids, polypeptides, transgenic animals comprising the same, antibodies thereto, and methods of use thereof
    Patent number: 7332643
    Abstract: Nucleic acids encoding a novel ferritin light chain variant, a ferritin light chain variant polypeptide, ferritin light chain variant polypeptide-specific antibodies, and methods of use thereof are provided herein. Also provided are methods to screen and identify agents capable of modulating the activity of the ferritin light chain variant.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: February 19, 2008
    Assignee: Indiana University & Technology Corp.
    Inventors: Bernardino Ghetti, Ruben Vidal
  • Ferritin light subunit variant-encoding nucleic acids, polypeptides, transgenic animals comprising the same, antibodies thereto, and methods of use thereof
    Publication number: 20040259107
    Abstract: Nucleic acids encoding a novel ferritin light chain variant, a ferritin light chain variant polypeptide, ferritin light chain variant polypeptide-specific antibodies, and methods of use thereof are provided herein. Also provided are methods to screen and identify agents capable of modulating the activity of the ferritin light chain variant.
    Type: Application
    Filed: October 14, 2003
    Publication date: December 23, 2004
    Inventors: Bernardino Ghetti, Ruben Vidal
  • Methods and compositions for diagnosing tauopathies
    Publication number: 20020018995
    Abstract: The present invention relates generally to methods and compositions for the diagnosis, modeling and treatment of tau-related pathologies. In particular, the present invention shows that mutations in the tau gene lead to neurofibrillary tangle formation. More specifically gene mutations are described that lead to alterations in ratios of tau isoforms are shown to lead to the formation of abnormal tau filaments.
    Type: Application
    Filed: November 29, 2000
    Publication date: February 14, 2002
    Applicant: Advanced Research and Technology
    Inventors: Bernardino Ghetti, Maria Grazia Spillantini, Jill R. Murrell, Michel Goedert, Martin Farlow, Aaron Klug
  • Transgenic mouse expressing APP770-V717F
    Patent number: 6184435
    Abstract: Methods for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also described are transgenic non-human mammals, especially transgenic mice, harboring an expressable gene sequence encoding human amyloid precursor protein having a phenyalanine for valine amino acid substitution in the transmembrane domain of the amyloid precursor protein.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 6, 2001
    Assignee: Advanced Research and Technology Institute
    Inventors: Merrill D. Benson, Jill Murrell, Martin Farlow, Bernardino Ghetti
  • Method for screening for alzheimer's disease
    Patent number: 5879883
    Abstract: Method for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also described are transgenic mammals harboring an expressable gene sequence encoding human amyloid precursor protein having a phenyanine for valine amino acid substitution in the transmembrane domain of the amyloid precursor protein.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: March 9, 1999
    Assignee: Indiana University Foundation
    Inventors: Merrill D. Benson, Jill Murrell, Martin Farlow, Bernardino Ghetti