Abstract: A system and method are provided for diagnosing and generating an alert for a medical condition using procedures initiated by symptoms being experienced by a patient. Diagnostic procedures are initiated in response to the patient entering specific symptoms the patient is experiencing through a patient activator device. The patient activator device may then acquire more information related to the symptoms from the patient, instruct an implantable medical device to perform measurements of certain physiological parameters related to the symptoms, or instruct the patient to perform certain tests. The symptoms and data collected from the patient and medical device are transmitted to a remote diagnostic device for performing clinical decisions based on such information and determining whether the patient is experiencing a particular medical condition.