Patents by Inventor Bernd Baumstuemmler

Bernd Baumstuemmler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9901893
    Abstract: The invention relates to an apparatus and method for the production of dispersions and solids by way of controlled precipitation, co-precipitation and self-organization processes in a microjet reactor, a jet of solvent containing at least one target molecule and a jet of nonsolvent colliding with each other, at specified pressures and flow rates, at a collision point in the reactor chamber of the microjet reactor, and the microjet reactor having a gas inlet for introducing gas into the reactor chamber and an educt outlet for discharging the educts in a stream of gas. This results in very rapid precipitation, co-precipitation or a chemical reaction, during the course of which micro- or nanoparticles form.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: February 27, 2018
    Assignee: Instillo GmbH
    Inventors: Bernd Penth, Felix Penth, Bernd Baumstuemmler, Akif Emre Tuereli
  • Patent number: 9585842
    Abstract: The present invention is directed to a pharmaceutical composition comprising guanfacine or a salt thereof in nanoparticle form and at least one non-pH dependent sustained release agent. The present invention further is directed to a method of producing said nanoparticles and to nanoparticles obtained by this method.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: March 7, 2017
    Assignee: SALMON PHARMA GMBH
    Inventors: Akif Emre Tuereli, Bernd Baumstuemmler, Richard Ammer
  • Publication number: 20160058708
    Abstract: The present invention is directed to a pharmaceutical composition comprising guanfacine or a salt thereof in nano particle form and at least one non-pH dependent sustained release agent. The present invention further is directed to a method of producing said nanoparticles and to nanoparticles obtained by this method.
    Type: Application
    Filed: April 28, 2014
    Publication date: March 3, 2016
    Inventors: Akif Emre Tuereli, Bernd Baumstuemmler, Richard Ammer
  • Publication number: 20150050210
    Abstract: The present invention is related to the field of pharmaceutical compositions for the treatment of various disease states, particularly neoplastic diseases and autoimmune diseases. It especially relates to the oral application of bendamustine and its derivatives. The invention further relates to a process for preparing a pharmaceutical composition which comprises bendamustine and its derivatives prepared by hot melt extrusion using pharmaceutically acceptable excipients. The invention also relates to such pharmaceutical compositions and hot melt extrudates.
    Type: Application
    Filed: March 25, 2013
    Publication date: February 19, 2015
    Inventors: Akif Emre Tuereli, Bernd Baumstuemmler, Richard Ammer
  • Patent number: 8852644
    Abstract: The invention relates to a method for producing microparticles or nanoparticles of water-soluble and water-insoluble substances by controlled precipitation, co-precipitation and self-organization processes in microjet reactors, a solvent, which contains at least one target molecule, and a nonsolvent being mixed as jets that collide with each other in a microjet reactor at defined pressures and flow rates and thereby effect very rapid precipitation, co-precipitation or a chemical reaction, during the course of which microparticles or nanoparticles are formed.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: October 7, 2014
    Assignee: Instillo GmbH
    Inventors: Bernd Baumstuemmler, Bernd Penth, Felix Penth, Akif Emre Tuereli
  • Patent number: 8697131
    Abstract: Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: April 15, 2014
    Assignee: Instillo GmbH
    Inventors: Akif Emre Tuereli, Bernd Penth, Peter Langguth, Bernd Baumstuemmler
  • Publication number: 20130012551
    Abstract: The invention relates to a method for producing microparticles or nanoparticles of water-soluble and water-insoluble substances by controlled precipitation, co-precipitation and self-organization processes in microjet reactors, a solvent, which contains at least one target molecule, and a nonsolvent being mixed as jets that collide with each other in a microjet reactor at defined pressures and flow rates and thereby effect very rapid precipitation, co-precipitation or a chemical reaction, during the course of which microparticles or nanoparticles are formed.
    Type: Application
    Filed: March 21, 2011
    Publication date: January 10, 2013
    Applicant: MJR PHARMJET GMBH
    Inventors: Bernd Baumstuemmler, Bernd Penth, Felix Penth, Akif Emre Tuereli
  • Publication number: 20110294770
    Abstract: Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers.
    Type: Application
    Filed: February 11, 2010
    Publication date: December 1, 2011
    Applicant: MJR PharmJet GmbH
    Inventors: Akif Emre Tuereli, Bernd Penth, Peter Langguth, Bernd Baumstuemmler