Abstract: The invention relates to a centrifuge (10), in particular a laboratory centrifuge, having a) a rotor (32) for receiving containers having material for centrifuging, b) a drive shaft (42), on which the rotor (32) is mounted, c) a motor (18), which drives the rotor (32) via the drive shaft (42), d) a bearing unit (44) having bearings (20, 22, 24; 46, 48, 50, 52, 54, 56; 64, 66, 68), which each have damping elements (20a, 22a, 24a; 46a, 48a, 50a; 52a, 54a, 56a, 64a, 66a, 68a) comprising a spring axis (20e, 22e, 24e; 46e, 48e, 50e; 52e, 54e, 56e; 64e, 66e, 68e), and e) a carrier element (16) for fixing the motor (18) via the bearing unit (44) in the centrifuge (10). The invention is characterized in that at least one damping element is formed completely from metal and as a metal cushion (46a, 48a, 50a; 52a, 54a, 56a, 64a, 66a, 68a) comprising a wire knit having elastic properties.

Abstract: The present invention relates to a pre-filled syringe containing a VEGF antagonist and comprising a plastic barrel which is silicone-free, kits comprising this syringe and the use of the syringe for the administration of a VEGF antagonist in the treatment of ocular diseases.

Abstract: The present invention relates to a pre-filled syringe containing a VEGF antagonist and comprising a plastic barrel which is silicone-free, kits comprising this syringe and the use of the syringe for the administration of a VEGF antagonist in the treatment of ocular diseases.

Abstract: A centrifuge (10), in particular a laboratory centrifuge, comprising a rotor (12) for receiving containers with material to be centrifuged, a drive shaft (14) on which the rotor (12) is supported, a motor (18) which drives the rotor (12) via the drive shaft, a bearing unit (30) with damping elements (36) each having a spring axis (36a), and a support element (54) for fixing the motor (18) in the centrifuge via the bearing unit (30), wherein the spring axes (36a) of the damping elements (36) are placed at an acute angle ? to the rotational axis Y of the motor (18). The invention is characterized in that the bearing unit (30) comprises a plurality of struts (34), preferably 3 to 21, which are connected to the damping elements (36), wherein the struts (34) are placed and arranged so that they are concentrically aligned with the respective spring axis.

Abstract: The present invention relates to a pre-filled syringe containing a VEGF antagonist and comprising a plastic barrel which is silicone-free, kits comprising this syringe and the use of the syringe for the administration of a VEGF antagonist in the treatment of ocular diseases.

Abstract: The present invention relates to a pre-filled syringe containing a VEGF antagonist and comprising a plastic barrel which is silicone-free, kits comprising this syringe and the use of the syringe for the administration of a VEGF antagonist in the treatment of ocular diseases.

Abstract: The invention relates to a centrifuge (10), in particular a laboratory centrifuge, comprising a rotor (12) for receiving containers with material to be centrifuged, a drive shaft (14) on which the rotor (12) is supported, a motor (18) which drives the rotor (12) via the drive shaft, a bearing unit (30) with damping elements (36) each having a spring axis (36a), and a support element (54) for fixing the motor (18) in the centrifuge via the bearing unit (30), wherein the spring axes (36a) of the damping elements (36) are placed at an acute angle ? to the rotational axis Y of the motor (18). The invention is characterized in that the bearing unit (30) comprises a plurality of struts (34), preferably 3 to 21, which are connected to the damping elements (36), wherein the struts (34) are placed and arranged so that they are concentrically aligned with the respective spring axis.

Abstract: According to the claims, the present invention comprises the preparation of chemically modified, cross-linked hemoglobins with improved functional properties, the cross-linked hemoglobins prepared according to this method and the use of these hemoglobins as artificial oxygen carriers. The synthesis method is characterized by technical simplicity as well as by high yields. Deoxygenated hemoglobin of high purity is conjugated covalently under the protection of an antioxidant with an effector of oxygen binding, especially with pyridoxal-5-phosphate, after which the hemoglobin is polymerized with glutardialdehyde as a bifunctional cross-linking agent. At the same time, there is a large increase in the volume of the reaction mixture and a decrease in the concentration of the hemoglobin during the addition of the cross-linking agent. Subsequently, after further dilution with water, a polyethylene oxide derivative is chemically linked to the cross-linked hemoglobins.

Abstract: According to the claims, the present invention comprises the preparation of chemically modified, cross-linked hemoglobins with improved functional properties, the cross-linked hemoglobins prepared according to this method and the use of these hemoglobins as artificial oxygen carriers. The synthesis method is characterized by technical simplicity as well as by high yields.

Abstract: Plate-shaped fire-resistant elements in a sandwich construction have at least three layers connected with one another and resist fire from a front and a back side. The fire-resistant elements are intended in particular for a ceiling or a wall of a building. The elements have a light weight, a high mechanical stability, and can be easily and inexpensively manufactured and installed in a building. The fire-resistant elements have two outer layers and a center layer lying therebetween in the form of a plate, whereby the edge area of the two outer layers is enclosed on at least two oppositely lying sides. Each side has an edge section and the layers are connected with one another. The outer layers have expandable glass granulate or perlite, and the center layer is constructed to prevent passage or penetration of gases.

Abstract: A dimensionally stable and fireproof acoustic panel includes an underlying panel covered on one or both sides by a cover panel. The underlying panel can be produced with a cover layer on the interior side thereof. The cover layer is composed of two layers, a coarse-pored stabilizing intermediate layer which in turn is covered by a second, fine-pored outer layer, both of which are bonded to one another and to the underlying panel by a matrix of adhesive material.

Abstract: A sound-absorbing building panel for lining of the inside walls and ceilings, in particular ceiling tile, consists of a carrier panel to be arranged spaced from a wall, which carrier panel is advantageously a perforated sheet metal and to which on at least one side a sound-absorbing, microporous layer is applied. Such a building panel, which does not require an insulation layer as a backing and can, moreover, be manufactured inexpensively, has a sound-absorbing layer of granules which are surrounded on all sides by an adhesive coating. The granules are essentially designed ball-shaped and are adhesively connected together at point-like connections and to the carrier panel. The granules also have a diameter between 0.1 to 0.9 times of the hole diameter of the carrier panel.

Abstract: The invention relates to the natural substance cyclamenol of the formula ##STR1## a process for its preparation from microorganisms of the order of the Actinomycetales, in particular from the Streptomyces strain MHW 846, chemical derivatives thereof, and its use as a medicament, in particular for acute and chronic inflammatory disorders in human and veterinary medicine.

Abstract: Substituted antithrombotic substituted cycloalkano[b]dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0,1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine,with the proviso, that in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group, or a salt thereof.

Abstract: Iso- and heterocyclic phenylsulphonamides can be prepared by reaction of corresponding iso- and heterocyclic amines with phenylsulphonic acid derivatives. The iso- and heterocyclic phenylsulphonamides have thrombocyte aggregation-inhibiting and thromboxane A.sub.2 antagonist action and can be used in medicaments.

Abstract: Iso- and heterocyclic phenylsulphonamides can be prepared by reaction of corresponding iso- and heterocyclic amines with phenylsulphonic acid derivatives. The iso- and heterocyclic phenylsulphonamides have thrombocyte aggregation-inhibiting and thromboxane A.sub.2 antagonist action and can be used in medicaments.

Abstract: Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1, 2, 3 or 4,n is 0, 1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine, with the proviso that, in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group,or a salt thereof.

Abstract: Tetrahydro-1-benz-[c,d],indolepropionic acid sulphonamides of the formula ##STR1## can be prepared by reaction of tetrahydro-1-benz-[c,d]-indolesulphonamides with acrylonitrile and subsequent hydrolysis. The new compounds can be employed inhibiting thrombocyte aggregation.

Abstract: Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0, 1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine, with the proviso that, in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group,or a salt thereof.

Abstract: Inhibiting platelet aggregation and antagonizing thromboxane A.sub.2 with new 2-halogen-substituted N-indolyethyl-sulphonamides of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl having up to 8 carbon atoms, orrepresents straight-chain or branched alkyl having up to 8 carbon atoms, or represents cycloalkyl having 3 to 8 carbon atoms, which is optionally substituted by carboxyl, halogen, alkoxy or alkoxycarbonyl having in each case up to 8 carbon atoms, cyano or hydroxyl, orrepresents a group of the formula --S(O).sub.n --R.sup.5,--NR.sup.6 R.sup.7 or --OR.sup.