Abstract: A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.

Abstract: A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.

Abstract: A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.

Abstract: A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.

Abstract: A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.

Abstract: A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.

Abstract: A sample injector (200) for use in a fluid separation system (10) for separating compounds of a fluidic sample in a mobile phase, the sample injector (200) comprising a switchable valve (202), a sample loop (204) in fluid communication with the valve (202) and configured for receiving the fluidic sample, a metering device (206) in fluid communication with the sample loop (204) and configured for introducing a metered amount of the fluidic sample on the sample loop (204), and a control unit (208) configured for controlling switching of the valve (202) to transfer the sample loop (204) between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device (206) during the intermediate state to at least partially equilibrate a pressure difference in the sample loop (204) between the low pressure state and the high pressure state.

Abstract: A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.

Abstract: A sample injector (200) for use in a fluid separation system (10) for separating compounds of a fluidic sample in a mobile phase, the sample injector (200) comprising a switchable valve (202), a sample loop (204) in fluid communication with the valve (202) and configured for receiving the fluidic sample, a metering device (206) in fluid communication with the sample loop (204) and configured for introducing a metered amount of the fluidic sample on the sample loop (204), and a control unit (208) configured for controlling switching of the valve (202) to transfer the sample loop (204) between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device (206) during the intermediate state to at least partially equilibrate a pressure difference in the sample loop (204) between the low pressure state and the high pressure state.

Abstract: A focusing unit for a fluidic system adapted for processing a mobile phase containing a fluidic sample, the fluidic system having a first processing element and a second processing element each for interacting with the mobile phase, wherein the mobile phase is to be conducted through the first and second processing elements, wherein the focusing unit is adapted for being coupled to an inlet of the second processing element and is adapted for modifying an elution strength of the mobile phase in order to spatially focus at least a portion of the fluidic sample in a region close to the inlet of the second processing element.

Abstract: The invention provides an analytical system having a separating system and a liquid chromatography chip. The liquid chromatography chip has an emitter that includes a material that prevents charge buildup on the emitter surface. Methods of using the analytical system, chip and emitter are also disclosed.

Abstract: A packing composition for inserting in a fluidic device, the packing composition having a packing material adapted for separating different components of a sample, and an adhesive substance to adhere to the packing material.

Abstract: A microfluidic chip with at least one inlet port, with at least one microfluidic flow path coupled to the inlet port, and with at least one analytical element adapted for analyzing and/or separating components of a liquid within the flow path which is arranged within or adjacent to, and/or is coupled to the microfluidic flow path. The microfluidic chip is adapted to execute at least two processes in parallel.

Abstract: The invention concerns a method supplying volume streams of fluids in channels or capillaries of small stream cross sections, more particularly chromatographic separating columns for the analytical fluid metrology, wherein a delivery device for delivering a volume stream of the fluid through an operating channel and a pressure measuring device for measuring the pressure in the operating channel is provided, wherein a measurement of the volume stream is possible, characterized by the following steps: a) Recording a time reference pressure course using the pressure measuring device in the operating channel, while the delivery device delivers an essentially constant, pre-determinable reference volume stream through the operating channel of a fluid with properties, more particularly flow properties, varying over time; b) Calculation of a time development of the operating pressure, which corresponds to the essentially constant and preferably small operating volume stream through the operating channel, which is d

Abstract: The invention concerns a method supplying volume streams of fluids (34) in channels or capillaries of small stream cross sections, more particularly chromatographic separating columns (34) for the analytical fluid metrology, wherein a delivery device (21) for delivering a volume stream of the fluid (34) through an operating channel (33) and a pressure measuring device (26) for measuring the pressure in the operating channel (33) is provided, wherein a measurement of the volume stream is possible, characterized by the following steps:

Abstract: A connecting capillary for analytical measuring-technology, in particular for high pressure liquid chromatography and for capillary electrophoresis, comprises a glass capillary, in particular a fused silica capillary, which is characterized in that the glass capillary is surrounded at least it its end regions by a sheath of polyetheretherketone (PEEK) or a PEEK-derivative.

Abstract: In a method for the manufacture of plastic parts which are used in an analytical measuring device and there come into contact with liquids, plastic base material is mixed with a suspension liquid and then extruded in the form desired. Before it is mixed with the plastic base material, aromatic and olefinic substances are removed from the suspension liquid by means of a chemical reaction, for instance, so that the final plastic products are free from such substances. In that way, it is avoided that, when using the plastic parts in an analytical measuring device, it may come to interferences of the detection by extraction of such substances into the flow of liquids and transportation into the detector. A vacuum degasser is a particularly advantageous field of application for the plastic parts manufactured in accordance with the invention.

Abstract: Herein described is a process for the chromatographic determination of ions, particularly anions on a reversed-phase column, in which sample ions are introduced into a mobile phase containing a modifier and a counterion, the mobile phase with the modifier, counterion and sample ions is passed through the column and, after separation with the aid of a suitable detection method, preferably an indirect UV-detection method, the individual sample ions are determined quantitatively via the decrease the counterion concentration in the eluent. In this process the mobile phase is a mixture of water an an organic solvent and has a pH-value of more than 5. The modifier used is a quaternary ammonium hydroxide of formula ##STR1## in which at least one radical is a straight-chained or branched alkyl radical with at least 8 and up to 20, more particularly 12 to 18 C-atoms.