Patents by Inventor Bernd Heiser

Bernd Heiser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral phosphorus compounds
    Patent number: 5488172
    Abstract: Novel chiral phosphorus compounds of the formula ##STR1## wherein R signifies lower alkyl, R.sup.1 signifies phenyl and R.sup.2 and R.sup.3 signify hydrogen or lower alkoxy,which are suitable in the form of complexes with a metal of Group VIII as catalysts for asymmetric hydrogenations and for enantioselective hydrogen displacements in prochiral allylic systems.
    Type: Grant
    Filed: August 23, 1994
    Date of Patent: January 30, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Marco Cereghetti, Joseph Foricher, Bernd Heiser, Rudolf Schmid
  • Isoquinoline derivatives
    Patent number: 5360908
    Abstract: A process for the preparation of isoquinoline derivatives of the formulas ##STR1## wherein R.sup.1 and R.sup.2 have the significances herein after set forth in the description, is described.The compounds of formula IV are obtained by asymmetrically hydrogenating the compounds of formula I.
    Type: Grant
    Filed: September 26, 1991
    Date of Patent: November 1, 1994
    Assignee: Hoffman-LaRoche Inc.
    Inventors: Emil A. Broger, Bernd Heiser
  • Chiral phosphines
    Patent number: 5302738
    Abstract: Novel, racemic and optically active phosphorus compounds of the formula ##STR1## wherein R signifies lower alkyl, lower alkoxy or protected hydroxy, R.sup.1 signifies lower alkoxy, phenoxy, benzyloxy, chlorine or bromine, R.sup.2 stands for lower alkyl or lower alkoxy and n represents the number 0, 1 or 2, are described. These compounds are valuable intermediates in the manufacture of not only known, but also novel diphosphine ligands.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: April 12, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Joseph Foricher, Bernd Heiser, Rudolf Schmid
  • Chirale phosphines
    Patent number: 5274125
    Abstract: Novel, racemic and optically active phosphorus compounds of the formula ##STR1## wherein R signifies lower alkyl, lower alkoxy or a protected hydroxy group, R.sup.1 signifies a five membered heteroaromatic ring, R.sup.2 stands for lower alkyl or lower alkoxy and n represents the number 0, 1 or 2, are described. The compounds of formula I serve in the form of complexes with a metal of Group VIII as catalyst for asymmetric hydrogenations and for enantioselective hydrogen displacements in prochiral allylic systems.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: December 28, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Emil A. Broger, Joseph Foricher, Bernd Heiser, Rudolf Schmid
  • Isomerization
    Patent number: 4861890
    Abstract: A process for producing chiral enamines by isomerizing a beta, gamma unsaturated amine with a rhodium-diphosphine complex with the addition of an achiral triarylphosphine and, if desired, hydrolyzing the compound of the enamine I obtained to the corresponding aldehyde.
    Type: Grant
    Filed: August 10, 1987
    Date of Patent: August 29, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Heiser, Hansjorg Stoller
  • Isoquinoline derivatives
    Patent number: 4857648
    Abstract: The invention is concerned with novel isoquinoline derivatives of the formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, lower alkoxy, aryl, aryloxy, aryl-lower alkyl or aryl-lower alkoxy andR.sup.2 is phenyl or substituted phenyl.These novel isoquinoline derivatives are valuable intermediates in the manufacture of morphinan derivatives.
    Type: Grant
    Filed: November 8, 1988
    Date of Patent: August 15, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Emil A. Broger, Yvo Crameri, Bernd Heiser