Patents by Inventor Bernd Henkel

Bernd Henkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for cleavage of solid phase-bound peptides from the solid phase
    Patent number: 11560402
    Abstract: The invention relates to a method for the cleavage of a solid phase-bound polypeptide from the solid phase, the method comprising contacting the solid phase, to which the polypeptide is bound, with a composition consisting essentially of trifluoroacetic acid and 1,2-ethanedithiol, at a temperature in the range of about 23° C. to about 29° C.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: January 24, 2023
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Wolfgang Fiedler, Norbert Pleuss, Bernd Henkel, Manfred Gerken
  • Capping of unprotected amino groups during peptide synthesis
    Patent number: 11028123
    Abstract: The present invention relates to a method for the synthesis of a polypeptide comprising a pre-determined amino acid sequence. The method according to the invention comprises coupling cycles of coupling an N-terminally protected amino acid building block C-terminally at an unprotected N-terminal amino group of an amino acid chain, wherein at least one coupling cycle comprises a coupling step (a), a capping step (b), and a de-protecting step (c).
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: June 8, 2021
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Bernd Henkel, Tobias Metzenthin, Manfred Gerken, Wolfgang Fiedler
  • Method of preparing peptides comprising a lipophilically modified lysine side chain
    Patent number: 11021512
    Abstract: The present invention relates to a method of preparing a lysine side-chain modified peptide by solid phase peptide synthesis.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: June 1, 2021
    Assignee: SANOFI
    Inventors: Bernd Henkel, Norbert Pleuss, Rolf-Ludwig Hoerlein
  • Exendin-4 derivatives as dual GLP1/glucagon agonists
    Patent number: 10758592
    Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: September 1, 2020
    Assignee: SANOFI
    Inventors: Torsten Haack, Michael Wagner, Bernd Henkel, Siegfried Stengelin, Andreas Evers, Martin Bossart
  • METHOD OF PREPARING PEPTIDES COMPRISING A LIPOPHILICALLY MODIFIED LYSINE SIDE CHAIN
    Publication number: 20200024304
    Abstract: The present invention relates to a method of preparing a lysine side-chain modified peptide by solid phase peptide synthesis.
    Type: Application
    Filed: October 10, 2017
    Publication date: January 23, 2020
    Inventors: Bernd HENKEL, Norbert PLEUSS, Rolf-Ludwig HOERLEIN
  • CAPPING OF UNPROTECTED AMINO GROUPS DURING PEPTIDE SYNTHESIS
    Publication number: 20190330263
    Abstract: The present invention relates to a method for the synthesis of a polypeptide comprising a pre-determined amino acid sequence. The method according to the invention comprises coupling cycles of coupling an N-terminally protected amino acid building block C-terminally at an unprotected N-terminal amino group of an amino acid chain, wherein at least one coupling cycle comprises a coupling step (a), a capping step (b), and a de-protecting step (c).
    Type: Application
    Filed: April 10, 2019
    Publication date: October 31, 2019
    Inventors: Bernd Henkel, Tobias Metzenthin, Manfred Gerken, Wolfgang Fiedler
  • METHOD FOR CLEAVAGE OF SOLID PHASE-BOUND PEPTIDES FROM THE SOLID PHASE
    Publication number: 20190330266
    Abstract: The invention relates to a method for the cleavage of a solid phase-bound polypeptide from the solid phase, the method comprising contacting the solid phase, to which the polypeptide is bound, with a composition consisting essentially of trifluoroacetic acid and 1,2-ethanedithiol, at a temperature in the range of about 23° C. to about 29° C.
    Type: Application
    Filed: April 10, 2019
    Publication date: October 31, 2019
    Inventors: Wolfgang FIEDLER, Norbert PLEUSS, Bernd HENKEL, Manfred GERKEN
  • Synthesis of cyclic imide containing peptide products
    Patent number: 10450343
    Abstract: The present invention relates to a method of synthesizing a peptide product comprising at least one cyclic imide group. Further, the invention relates to a peptide product comprising at least one cyclic imide group, which is substantially free from degradation products. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of a GLP-1 agonist like exendin peptides.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: October 22, 2019
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventor: Bernd Henkel
  • Functionalized Exendin-4 derivatives
    Patent number: 10253079
    Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: April 9, 2019
    Assignee: SANOFI
    Inventors: Torsten Haack, Michael Wagner, Bernd Henkel, Siegfried Stengelin, Andreas Evers, Martin Lorenz, Katrin Lorenz
  • Synthesis of hydantoin containing peptide products
    Patent number: 10087221
    Abstract: The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: October 2, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: Bernd Henkel
  • EXENDIN-4 DERIVATIVES AS DUAL GLP1/GLUCAGON AGONISTS
    Publication number: 20180185450
    Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
    Type: Application
    Filed: December 11, 2017
    Publication date: July 5, 2018
    Inventors: Torsten Haack, Michael Wagner, Bernd Henkel, Siegfried Stengelin, Andreas Evers, Martin Bossart
  • Exendin-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists
    Patent number: 9982029
    Abstract: The present invention relates to dual GLP-1/glucagon receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: May 29, 2018
    Assignee: SANOFI
    Inventors: Martin Bossart, Andreas Evers, Torsten Haack, Katrin Lorenz, Dieter Kadereit, Michael Wagner, Bernd Henkel
  • Exendin-4 derivatives as selective glucagon receptor agonists
    Patent number: 9932381
    Abstract: The present invention relates to glucagon receptor agonists and their medical use, for example in the treatment of severe hypoglycemia.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: April 3, 2018
    Assignee: Sanofi
    Inventors: Torsten Haack, Siegfried Stengelin, Andreas Evers, Michael Wagner, Bernd Henkel
  • Exendin-4 peptide analogues as dual GLP-1/GIP receptor agonists
    Patent number: 9789165
    Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: October 17, 2017
    Assignee: SANOFI
    Inventors: Dieter Kadereit, Katrin Lorenz, Andreas Evers, Torsten Haack, Michael Wagner, Bernd Henkel, Martin Lorenz, Siegfried Stengelin
  • Dual GLP-1/GIP receptor agonists
    Patent number: 9751926
    Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: September 5, 2017
    Assignee: SANOFI
    Inventors: Dieter Kadereit, Katrin Lorenz, Andreas Evers, Torsten Haack, Michael Wagner, Bernd Henkel, Martin Lorenz, Siegfried Stengelin
  • Non-acylated exendin-4 peptide analogues
    Patent number: 9750788
    Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: September 5, 2017
    Assignee: SANOFI
    Inventors: Dieter Kadereit, Katrin Lorenz, Andreas Evers, Torsten Haack, Michael Wagner, Bernd Henkel, Martin Lorenz, Siegfried Stengelin
  • Dual GLP1/GIP or trigonal GLP1/GIP/glucagon agonists
    Patent number: 9745360
    Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: August 29, 2017
    Assignee: SANOFI
    Inventors: Torsten Haack, Michael Wagner, Bernd Henkel, Siegfried Stengelin, Andreas Evers, Martin Lorenz, Katrin Lorenz
  • FUNCTIONALIZED EXENDIN-4 DERIVATIVES
    Publication number: 20170216406
    Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
    Type: Application
    Filed: April 12, 2017
    Publication date: August 3, 2017
    Inventors: Torsten Haack, Michael Wagner, Bernd Henkel, Siegfried Stengelin, Andreas Evers, Martin Lorenz, Katrin Lorenz
  • Dual GLP-1/glucagon receptor agonists
    Patent number: 9694053
    Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: July 4, 2017
    Assignee: SANOFI
    Inventors: Torsten Haack, Michael Wagner, Bernd Henkel, Siegfried Stengelin, Andreas Evers, Martin Bossart, Dieter Kadereit
  • Functionalized exendin-4 derivatives
    Patent number: 9670261
    Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: June 6, 2017
    Assignee: SANOFI
    Inventors: Torsten Haack, Michael Wagner, Bernd Henkel, Siegfried Stengelin, Andreas Evers, Martin Lorenz, Katrin Lorenz