Patents by Inventor Bernd Hiller

Bernd Hiller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11261473
    Abstract: A method and an apparatus are described for the generation of microparticles containing an immobilized functional component, where the following measures are proposed: spraying a liquid (32) containing a soluble alginate and a functional component consisting of molecules or nanoparticles to generate a stream (60) of droplets, directing the stream (60) of droplets onto a precipitation bath (16) and capturing the droplets therein by application of high voltage (14), precipitating the droplets in the precipitation bath (16) via a precipitation liquid (18) containing an alginate complexing agent, such that the droplets are solidified to form microparticles (10) containing the functional component and extracting the microparticles (10) from the precipitation bath (16).
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: March 1, 2022
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Otto Fuerst, Herbert Harttig, Bernd Hiller
  • Patent number: 11134869
    Abstract: A sensor device for determining the concentration of an analyte under in-vivo conditions that includes an electrode system having an electrode with immobilized enzyme molecules and a diffusion barrier that controls diffusion from the exterior of the electrode system to the immobilized enzyme molecules. The diffusion barrier may include an aliphatic polyurethane. A process of manufacturing such a sensor device is also disclosed.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: October 5, 2021
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Herbert Fink, Bernd Hiller, Ulrich Mueller, Markus Siebenhaar, Christoph Grulke
  • Patent number: 11090650
    Abstract: A method for manufacturing a test element for detecting at least one analyte in a body fluid, a test element for detecting at least one analyte in a body fluid, a method for detecting at least one analyte in a body fluid, a system for detecting at least one analyte in a body fluid and a method for manufacturing a test element for detecting at least one analyte in a body fluid are disclosed.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: August 17, 2021
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Joerg Dreibholz, Volker Hullen, Maria Dambach, Herbert Fink, Daniela Pfiffi, Bernd Hiller, Carina Horn
  • Publication number: 20190282142
    Abstract: A sensor device for determining the concentration of an analyte under in-vivo conditions that includes an electrode system having an electrode with immobilized enzyme molecules and a diffusion barrier that controls diffusion from the exterior of the electrode system to the immobilized enzyme molecules. The diffusion barrier may include an aliphatic polyurethane. A process of manufacturing such a sensor device is also disclosed.
    Type: Application
    Filed: June 3, 2019
    Publication date: September 19, 2019
    Inventors: Herbert Fink, Bernd Hiller, Ulrich Mueller, Markus Siebenhaar, Christoph Grulke
  • Patent number: 10150114
    Abstract: Methods are disclosed for manufacture of test elements for detecting at least one analyte in a body fluid, where the test elements include a housing having at least one base element and at least one cover element. The methods include providing the base element, and mounting the cover element to the base element with an adhesive, wherein the adhesive contacts at least one test field of the cover element such that the adhesive is interposed between the test field and the base element and at least partially covers the test field. The test elements also include at least one fluid channel formed within the housing, where the the fluid channel includes a capillary region and a measurement region. The capillary region and the measurement region have differing aspect ratios. The at least one test field has at least one test chemical, where the test chemical is adapted to change at least one optically measurable property in the presence of the analyte.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: December 11, 2018
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Bernd Hiller, Rudolf Pachl, Daniela Pfiffi, Ewald Rieger, Christa Sternberger
  • Publication number: 20180345283
    Abstract: A method for manufacturing a test element for detecting at least one analyte in a body fluid, a test element for detecting at least one analyte in a body fluid, a method for detecting at least one analyte in a body fluid, a system for detecting at least one analyte in a body fluid and a method for manufacturing a test element for detecting at least one analyte in a body fluid are disclosed.
    Type: Application
    Filed: May 9, 2018
    Publication date: December 6, 2018
    Inventors: Joerg Dreibholz, Volker Hullen, Maria Dambach, Herbert Fink, Daniela Pfiffi, Bernd Hiller, Carina Horn
  • Publication number: 20180297030
    Abstract: Methods are disclosed for manufacture of test elements for detecting at least one analyte in a body fluid, where the test elements include a housing having at least one base element and at least one cover element. The methods include providing the base element, and mounting the cover element to the base element with an adhesive, wherein the adhesive contacts at least one test field of the cover element such that the adhesive is interposed between the test field and the base element and at least partially covers the test field. The test elements also include at least one fluid channel formed within the housing, where the the fluid channel includes a capillary region and a measurement region. The capillary region and the measurement region have differing aspect ratios. The at least one test field has at least one test chemical, where the test chemical is adapted to change at least one optically measurable property in the presence of the analyte.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 18, 2018
    Inventors: Bernd Hiller, Rudolf Pachl, Daniela Pfiffi, Ewald Rieger, Christa Sternberger
  • Patent number: 10029252
    Abstract: Test elements are disclosed for detecting at least one analyte in a body fluid, where the test elements include a housing having at least one base element and at least one cover element. The test elements also include at least one fluid channel formed within the housing, where the fluid channel includes a capillary region and a measurement region. The capillary region and the measurement region have differing aspect ratios. The cover element includes at least one test field having at least one test chemical, where the test chemical is adapted to change at least one optically measurable property in the presence of the analyte. In addition, the cover element is mounted to the base element via at least one adhesive that contacts the test field.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: July 24, 2018
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Bernd Hiller, Rudolf Pachl, Daniela Pfiffi, Ewald Rieger, Christa Sternberger
  • Patent number: 9877676
    Abstract: A method for producing an analytical tape, in particular a lancet tape, is proposed. The analytical tape is designed for being used in an analytical testing device with at least a sample-taking function. In the method, at least one supporting tape is provided in a continuous process. A plurality of lancet elements are successively applied directly to the supporting tape at at least one application point.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: January 30, 2018
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ahmet Konya, Bernd Hiller
  • Publication number: 20170226500
    Abstract: The invention concerns a method and an apparatus for generation of micropartides containing an immobilized functional component, where the following measures are proposed: —spraying a liquid (32) containing a soluble alginate and a functional component consisting of molecules or nanoparticles to generate a stream (60) of droplets, —directing the stream (60) of droplets onto a precipitation bath (16) and capturing the droplets therein by application of high voltage (14), —precipitating the droplets in the precipitation bath (16) by means of a precipitation liquid (18) containing an alginate complexing agent, such that the droplets are solidified to form micropartides (10) containing the functional component and —extracting the micropartides (10) from the precipitation bath (16).
    Type: Application
    Filed: July 23, 2015
    Publication date: August 10, 2017
    Applicant: Roche Diabetes Care, Inc.
    Inventors: Otto Fuerst, Herbert Harttig, Bernd Hiller
  • Publication number: 20160082434
    Abstract: Test elements are disclosed for detecting at least one analyte in a body fluid, where the test elements include a housing having at least one base element and at least one cover element. The test elements also include at least one fluid channel formed within the housing, where the fluid channel includes a capillary region and a measurement region. The capillary region and the measurement region have differing aspect ratios. The cover element includes at least one test field having at least one test chemical, where the test chemical is adapted to change at least one optically measurable property in the presence of the analyte. In addition, the cover element is mounted to the base element via at least one adhesive that contacts the test field.
    Type: Application
    Filed: December 7, 2015
    Publication date: March 24, 2016
    Inventors: Bernd Hiller, Rudolf Pachl, Daniela Pfiffi, Ewald Rieger, Christa Sternberger
  • Patent number: 8795199
    Abstract: A puncturing system includes a carrier tape carrying multiple lancets and having position marks, a housing comprising a conveying facility for positioning the lancets and a housing opening, a puncturing drive for accelerating a lancet positioned in a usage position, a storage medium for storing distance values that depend on distances between the lancets of the carrier tape and position marks allocated to the respective lancets, a sensor for detecting position marks in a detection position through which the position marks proceed upon motion of the carrier tape, and a control unit that controls the conveying facility. To position a lancet in the usage position, the control unit stops the conveying facility upon the carrier tape moving a positioning distance. The length of the positioning distance depends on the distance between the lancet to be positioned and the detected position mark and is determined by the control unit.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: August 5, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Herbert Harttig, Bernd Hiller, Ahmet Konya, Oliver Kube, Hans-Juergen Kuhr, Frederic Wehowski
  • Patent number: 8586376
    Abstract: Methods of producing an analysis spreading layer for absorbing a liquid to be analyzed, by: supplying a porous membrane having a bottom, a top and a thickness D, the size of the pores of the membrane increasing over its thickness D; cutting the membrane at a predefined distance, the spreading layer being a sublayer with a thickness d less than the starting thickness D, the pores of the spreading layer having a fluid connection to one another in such a manner that it is permeable to a liquid. The membrane surface is formed by removing a sublayer of the membrane being the liquid outlet side of the spreading layer. The mean size of the pores on the liquid outlet side is at least 1 ?m.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: November 19, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Herbert Harttig, Bernd Hiller, Wolfgang Schwoebel, Alexander Kasejew
  • Patent number: 8234767
    Abstract: Disclosed is a process for manufacturing packaged lancets. The steps of the process include providing a tape comprising a plurality of lancets comprising a lancet tip and a lancet body, enveloping at least the lancet tip with at least one foil, whereby the at least one foil forms a first and a second portion that overlap at least partly, and sealing the at least one foil with a laser beam at least at the edges of the first and second portion of the overlapping foil.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: August 7, 2012
    Assignee: Roche Diagonostics Operations, Inc.
    Inventors: Josef Roeper, Werner Finke, Herbert Harttig, Bernd Hiller, Hans List
  • Publication number: 20120189496
    Abstract: Methods of producing an analysis spreading layer for absorbing a liquid to be analyzed, by: supplying a porous membrane having a bottom, a top and a thickness D, the size of the pores of the membrane increasing over its thickness D; cutting the membrane at a predefined distance, the spreading layer being a sublayer with a thickness d less than the starting thickness D, the pores of the spreading layer having a fluid connection to one another in such a manner that it is permeable to a liquid. The membrane surface is formed by removing a sublayer of the membrane being the liquid outlet side of the spreading layer. The mean size of the pores on the liquid outlet side is at least 1 ?m.
    Type: Application
    Filed: December 20, 2011
    Publication date: July 26, 2012
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Herbert HARTTIG, Bernd HILLER, Wolfgang SCHWOEBEL, Alexander KASEJEW
  • Publication number: 20120184875
    Abstract: A method for producing an analytical tape, in particular a lancet tape, is proposed. The analytical tape is designed for being used in an analytical testing device with at least a sample-taking function. In the method, at least one supporting tape is provided in a continuous process. A plurality of lancet elements are successively applied directly to the supporting tape at at least one application point.
    Type: Application
    Filed: January 12, 2012
    Publication date: July 19, 2012
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Ahmet KONYA, Bernd HILLER
  • Publication number: 20120040386
    Abstract: There is proposed a diagnostic test element for detecting an analyte in a sample of a body fluid, more particularly in whole blood. The diagnostic test element comprises at least one test field having at least one detection reagent, wherein the detection reagent is set up to pass through at least one detectable change in the presence of the analyte, more particularly an optical change. The test field has at least one detection layer which comprises the detection reagent and which comprises particles. At least 90% of all particles of the detection layer have an actual particle size of less than 10 micrometers.
    Type: Application
    Filed: May 3, 2011
    Publication date: February 16, 2012
    Inventors: Wolfgang-Reinhold Knappe, Bernd Hiller, Ursula Lehr, Volker Zimmer, Wolfgang Petrich, Luis David Bedon-Gomez
  • Publication number: 20100292609
    Abstract: A method for manufacturing a carrier tape comprising lancets and corresponding products in which a plurality of disposable lancets having a lancet tip for piercing a user's skin are provided on a carrier tape that is or can be wound onto a spool and used for obtaining a sample of body fluid. The lancets can each be arranged in a package and the lancet packages formed in this manner can be applied individually to the carrier tape and fastened thereon.
    Type: Application
    Filed: November 16, 2009
    Publication date: November 18, 2010
    Inventors: Volker Zimmer, Frank Deck, Bernd Hiller, Ahmet Konya
  • Publication number: 20100222799
    Abstract: A process for manufacturing packaged lancets, comprising the steps: providing a tape comprising a plurality of lancets comprising a lancet tip and a lancet body, enveloping at least the lancet tip with at least one foil, whereby the at least one foil build a first and a second portion that overlap at least partly, sealing the at least one foil with a laser beam at least at the edges of the first and second portion of the overlapping parts.
    Type: Application
    Filed: March 18, 2010
    Publication date: September 2, 2010
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Josef Roeper, Werner Finke, Herbert Harttig, Bernd Hiller, Hans List
  • Publication number: 20100121369
    Abstract: A puncturing system includes a carrier tape carrying multiple lancets and having position marks, a device housing that comprises a conveying facility for positioning the lancets consecutively in a usage position by moving the carrier tape in a conveying direction and has a housing opening for touching against a body part in which a puncture is to be made by a puncturing motion of one of the lancets, a puncturing drive for accelerating one of the lancets that is positioned in the usage position for the puncturing motion, a storage medium on which distance values for the lancets are stored, the distance values depending on distances between the lancets of the carrier tape and position marks allocated to the respective lancets, a a sensor for detecting position marks in a detection position through which the position marks proceed upon a motion of the carrier tape that is effected by the conveying facility, and a control unit that is connected to the sensor for controlling the conveying facility, wherein, in ord
    Type: Application
    Filed: November 11, 2009
    Publication date: May 13, 2010
    Inventors: Herbert Harttig, Bernd Hiller, Ahmet Konya, Oliver Kube, Hans-Juergen Kuhr, Frederic Wehowski