Patents by Inventor Bernd Hinzmann
Bernd Hinzmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11913062Abstract: Present disclosure provides a method including isolating DNA from a source, thereby providing a composition including the isolated DNA. The isolated DNA has at least first and second target regions, where the length of the second target region is greater than the length of the first target region. The method further includes quantifying a total mass of the isolated DNA, quantifying a first quantification cycle (Cq) of the first target region and a second Cq of the second target region, and calculating a Q-ratio for the isolated DNA by dividing the second Cq by the first Cq. The method further includes determining a value for a quality-mass constant (kQm), estimating a required input mass by dividing kQm by the Q-ratio, and preparing the isolated DNA for sequencing if the total mass of the isolated DNA in the composition is equal or greater than the required input mass.Type: GrantFiled: November 18, 2019Date of Patent: February 27, 2024Assignees: Roche Sequencing Solutions, Inc., Signature Diagnostics GmbHInventors: Victoria Constandse, Daniel Klass, Alexander Lovejoy, Melissa Loyzer, Bronwen Miller, Bernd Hinzmann, Sophie Beckert
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Patent number: 11821041Abstract: The invention is a method of predicting recurrence of colorectal cancer in a patient following surgery, the method comprising analysis of circulating tumor DNA from a patient's sample.Type: GrantFiled: August 7, 2019Date of Patent: November 21, 2023Assignee: Roche Sequencing Solutions, Inc.Inventors: Hans-Peter Adams, Aarthi Balasubramanyam, Bernd Hinzmann, John Lee, John Palma, Andre Rosenthal, Urich-Peter Rohr
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Patent number: 11702697Abstract: The present invention provides method essentially comprising the steps of (i) providing a DNA sample, (ii) providing at least a first pair of amplification primers which is capable of generating a first amplicon from a LINE sequence that has a size of less than 80 bp, (iii) providing at least a second pair of amplification primers which is capable of generating a second amplicon from a LINE sequence that has a size of more than 160 bp, (iv) performing a qPCR and determining cq values for each of the generated amplicons, and (v) determining the relative concentrations of said amplicons.Type: GrantFiled: May 14, 2018Date of Patent: July 18, 2023Assignee: Roche Sequencing Solutions, Inc.Inventors: Sophie Beckert, Bernd Hinzmann
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Publication number: 20210214790Abstract: The present invention provides method essentially comprising the steps of (i) providing a DNA sample, (ii) providing at least a first pair of amplification primers which is capable of generating a first amplicon from a LINE sequence that has a size of less than 80 bp, (iii) providing at least a second pair of amplification primers which is capable of generating a second amplicon from a LINE sequence that has a size of more than 160 bp, (iv) performing a qPCR and determining cq values for each of the generated amplicons, and (v) determining the relative concentrations of said amplicons.Type: ApplicationFiled: May 14, 2018Publication date: July 15, 2021Inventors: Sophie Beckert, Bernd Hinzmann
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Publication number: 20200087708Abstract: Present disclosure provides a method including isolating DNA from a source, thereby providing a composition including the isolated DNA. The isolated DNA has at least first and second target regions, where the length of the second target region is greater than the length of the first target region. The method further includes quantifying a total mass of the isolated DNA, quantifying a first quantification cycle (Cq) of the first target region and a second Cq of the second target region, and calculating a Q-ratio for the isolated DNA by dividing the second Cq by the first Cq. The method further includes determining a value for a quality-mass constant (kQm), estimating a required input mass by dividing kQm by the Q-ratio, and preparing the isolated DNA for sequencing if the total mass of the isolated DNA in the composition is equal or greater than the required input mass.Type: ApplicationFiled: November 18, 2019Publication date: March 19, 2020Inventors: Victoria Constandse, Daniel Klass, Alexander Lovejoy, Melissa Loyzer, Bronwen Miller, Bernd Hinzmann, Sophie Beckert
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Publication number: 20190360059Abstract: The invention is a method of predicting recurrence of colorectal cancer in a patient following surgery, the method comprising analysis of circulating tumor DNA from a patient's sample.Type: ApplicationFiled: August 7, 2019Publication date: November 28, 2019Inventors: Hans-Peter Adams, Aarthi Balasubramanyam, Bernd Hinzmann, John Lee, John Palma, Andre Rosenthal, Urich-Peter Rohr
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Publication number: 20130065791Abstract: The invention pertains to a method for early detection and screening of colorectal cancer in human subjects based on RNA isolated from blood obtained from said subject. According to the invention, the abundance of at least 3, 5, 8, 30, 60, 102, 202, 55, 1002 or 1002 RNAs listed in tables 1 to 13 is measured. Using the invention, an accurate and noninvasive screening and diagnosis tool for colorectal cancer is provided with a sensitivity of at least 80% and a specificity of 85% that has high clinical utility and the potential for broad adoption.Type: ApplicationFiled: May 19, 2011Publication date: March 14, 2013Applicant: SIGNATURE DIAGNOSTICS AGInventors: André Rosenthal, Bernd Hinzmann, Tobias Mayr, Hans-Peter Adams
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Publication number: 20110287957Abstract: The invention pertains to a method for early detection and screening of colorectal cancer in human subjects based on RNA isolated from blood obtained from said subject. According to the invention, the expression of at least 3, 5, 8, 30, 60, 102, 202, 55, 1002 or 1002 RNAs listed in Tables 1-15 are measured. Using the invention, an accurate and noninvasive screening and diagnosis tool for colorectal cancer is provided with a sensitivity of at least 80% and a specificity of 85% that has high clinical utility and the potential for broad adoption.Type: ApplicationFiled: May 19, 2011Publication date: November 24, 2011Applicant: Signature Diagnostics AGInventors: Andre Rosenthal, Bernd Hinzmann, Tobias Mayr, Hans-Peter Adams
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Publication number: 20090269775Abstract: The invention relates to the use of gene expression profiles for predicting the probability of recurrence or metastases to develop in remote organs of patients from which a primary colon carcinoma has been removed.Type: ApplicationFiled: November 1, 2007Publication date: October 29, 2009Applicant: SIGNATURE DIAGNOSTICS AGInventors: Bernd Hinzmann, Hans-Peter Adams, Tobias Mayr, Djork-Arne Clevert
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Publication number: 20040009478Abstract: Human nucleic acid sequences—mRNA, cDNA, genomic sequences—from tissue of prostate tumors, which code for gene products or parts thereof and their use, are described. In addition, the polypeptides that can be obtained by way of the sequences and their use are described.Type: ApplicationFiled: April 25, 2002Publication date: January 15, 2004Applicant: Metagen Gesellschaft Fur Genomforschung MBHInventors: Thomas Specht, Bernd Hinzmann, Armin Schmitt, Christian Pilarsky, Edgar Dahl, Andre Rosenthal
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Publication number: 20040002471Abstract: Human nucleic acid sequences—mRNA, cDNA, genomic sequences—from normal pancreatic tissue, which code for gene products or portions thereof, and their use, are described. In addition, the polypeptides that can be obtained by way of the sequences and their use are described.Type: ApplicationFiled: December 30, 2002Publication date: January 1, 2004Applicant: Metagen Gesellschaft Fur Genomforschung MBHInventors: Thomas Specht, Bernd Hinzmann, Armin Schmitt, Christian Pilarsky, Edgar Dahl, Andre Rosenthal
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Publication number: 20030235915Abstract: Human nucleic acid sequences—mRNA, cDNA, genomic sequences—from breast tumor tissue, which code for gene products or parts thereof, and their use, are described. In addition, the polypeptides that can be obtained by way of the sequences and their use are described.Type: ApplicationFiled: April 25, 2002Publication date: December 25, 2003Applicant: Metagen Gesellschaft Fur Genomforschung MBHInventors: Thomas Specht, Bernd Hinzmann, Armin Schmitt, Christian Pilarsky, Edgar Dahl, Andre Rosenthal
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Patent number: 6620923Abstract: Human nucleic acid sequences—mRNA, cDNA, genomic sequences—from endometrial tumor tissue, which code for gene products or portions thereof, and their use, are described. In addition, the polypeptides that can be obtained by way of the sequences and their use are described.Type: GrantFiled: December 27, 2000Date of Patent: September 16, 2003Assignee: Metagen Pharmaceuticals GmbHInventors: Thomas Specht, Bernd Hinzmann, Armin Schmitt, Christian Pilarsky, Edgar Dahl, AndrĂ© Rosenthal
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Publication number: 20030170625Abstract: The invention relates to a process for detecting differential gene expressions and new nucleic acid sequences that can be obtained by this process.Type: ApplicationFiled: January 31, 2001Publication date: September 11, 2003Applicant: metaGen Gesellschaft fur Genomforschung mbHInventors: Andre Rosenthal, Bernd Hinzmann, Reinhold Schaffer, Johannes Zuber, Oleg Tchernitsa, Martin Grips, Martin Hellriegel, Anne-Chantal Schmitz, Christine Sers
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Publication number: 20030105315Abstract: The invention relates to human nucleic acid sequences—mRNA, cDNA, genome sequences—of ovarian tumour tissue, which code for gene products or parts of these products, and to their use. The invention also relates to the polypeptides obtained by way of these sequences and to the use of same.Type: ApplicationFiled: October 15, 2002Publication date: June 5, 2003Applicant: metaGen Pharmaceuticals GmbHInventors: Thomas Specht, Bernd Hinzmann, Armin Schmitt, Christian Pilarsky, Edgar Dahl, Andre Rosenthal
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Patent number: 6399348Abstract: DNA sequences for human matrix metalloproteases are disclosed, as well as homologous DNA sequences homologous and derived therefrom. Also disclosed are the proteins and protein variants coded by these DNA sequences, there expression, preparation and use. The invention has applications in the fields of biomolecular, medical and pharmaceutical research, for medical diagnosis and therapy, and in the pharmaceutical and biotechnological industry.Type: GrantFiled: March 8, 2000Date of Patent: June 4, 2002Assignee: Max-Delbrueck Centrum fuer Molekulare MedizinInventors: Horst Will, Bernd Hinzmann
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Patent number: 6114159Abstract: The invention relates to matrix metalloproteases and variants thereof and DNA sequences that encode these matrix metalloproteases. The invention further relates to obtaining the matrix metalloproteases from natural sources or by recombinant methods by expression of the DNA sequences. These matrix metalloproteases can also complexed with a ligand. The matrix metalloproteases are enzymes that hydrolyze one or more proteins of the extracellular matrix and are thought to contribute to local degradation of the extracellular matrix in tumor cell invasion and metastasis, rheumatoid arthritis, aneurysm formation, smooth muscle proliferation and migration processes in atherosclerotic disease.Type: GrantFiled: November 20, 1996Date of Patent: September 5, 2000Assignee: Max-Delbruck-Centrum fur Molekulare MedizinInventors: Horst Will, Bernd Hinzmann