Patents by Inventor Bernd Junghans

Bernd Junghans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the recovery of beta acetylfuranoside
    Patent number: 9580455
    Abstract: There is provided an improved method for the recovery of residual, unseparated ?-acetylfuranoside from reaction mixtures remaining from an initial synthesis of acetylfuranoside, which is in particular usable on a large industrial scale, more particularly in the production of capecitabine.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: February 28, 2017
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Martin Behringer, Bernd Junghans, Bernhard Knipp, Bernhard Pfeil, Gerald Zieres
  • Novel Process for the Recovery of Beta Acetylfuranoside
    Publication number: 20160333040
    Abstract: There is provided an improved method for the recovery of residual, unseparated ?-ACF from reaction mixtures remaining from an initial synthesis of ACF, which is in particular usable on a large industrial scale, more particularly in the production of capecitabine.
    Type: Application
    Filed: November 13, 2012
    Publication date: November 17, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Martin Behringer, Bernd Junghans, Bernhard Knipp, Bernhard Pfeil, Gerald Zieres
  • NOVEL PROCESS FOR THE RECOVERY OF BETA ACETYLFURANOSIDE
    Publication number: 20100190976
    Abstract: There is provided an improved method for the recovery of residual, unseparated ?-ACF from reaction mixtures remaining from an initial synthesis of ACF, which is in particular usable on a large industrial scale, more particularly in the production of capecitabine.
    Type: Application
    Filed: January 20, 2010
    Publication date: July 29, 2010
    Inventors: Martin Behringer, Bernd Junghans, Bernhard Knipp, Bernhard Pfeil, Gerald Zieres
  • Ibandronate polymorph
    Patent number: 7714158
    Abstract: The present invention relates to a new polymorph crystal form of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1 1-diphosphonic acid monosodium salt monohydrate (Ibandronate) with the following formula.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: May 11, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Uwe Eiermann, Bernd Junghans, Bernhard Knipp, Tim Sattelkau
  • Process for preparing ibandronate
    Patent number: 7662990
    Abstract: The invention relates to a novel multi step synthesis of 3-(N-methyl-N-pentyl)amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate, of the formula
    Type: Grant
    Filed: April 1, 2008
    Date of Patent: February 16, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Bernd Junghans
  • IBANDRONATE POLYMORPH
    Publication number: 20090312289
    Abstract: The present invention relates to a new crystalline polymorph of 3-(N-methyl-N-pentyl)amino-1-hydroxypropane-1,1-diphosphonic acid monosodium salt monohydrate (Ibandronate) with the following formula
    Type: Application
    Filed: July 17, 2009
    Publication date: December 17, 2009
    Inventors: Uwe Eiermann, Bernd Junghans, Bernhard Knipp, Tim Settelkau
  • Ibandronate polymorph
    Patent number: 7582789
    Abstract: The present invention relates to a new crystalline polymorph of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1,1-diphosphonic acid monosodium salt monohydrate (Ibandronate) with the following formula
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: September 1, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Uwe Eiermann, Bernd Junghans, Bernhard Knipp, Tim Sattelkau
  • PROCESS FOR PREPARING IBANDRONATE
    Publication number: 20080255386
    Abstract: The invention relates to a novel multi step synthesis of 3-(N-methyl-N-pentyl)amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate, of the formula
    Type: Application
    Filed: April 1, 2008
    Publication date: October 16, 2008
    Inventor: Bernd Junghans
  • Method for synthesizing bisphosphonate
    Patent number: 7214818
    Abstract: The invention relates to a novel multi step synthesis of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate, of the formula
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: May 8, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Friedrich Baetz, Bernd Junghans
  • Ibandronate polymorph
    Publication number: 20060172975
    Abstract: The present invention relates to a new polymorph crystal form of 3-(N-methyl-N-pentyl)amino-1-hydroxypropane-1 1-diphosphonic acid monosodium salt monohydrate (Ibandronate) with the following formula
    Type: Application
    Filed: January 24, 2006
    Publication date: August 3, 2006
    Inventors: Uwe Eiermann, Bernd Junghans, Bernhard Knipp, Tim Sattelkau
  • Ibandronate polymorph
    Publication number: 20060172976
    Abstract: The present invention relates to a new crystalline polymorph of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane -1,1-diphosphonic acid monosodium salt monohydrate (Ibandronate) with the following formula
    Type: Application
    Filed: January 24, 2006
    Publication date: August 3, 2006
    Inventors: Uwe Eiermann, Bernd Junghans, Bernhard Knipp, Tim Sattelkau
  • Method for synthesizing bisphosphonate
    Publication number: 20060094898
    Abstract: The invention relates to a novel multi step synthesis of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate, of the formula
    Type: Application
    Filed: October 18, 2005
    Publication date: May 4, 2006
    Inventors: Friedrich Baetz, Bernd Junghans
  • Methods for the preparation of 4-hydroxy benzothiophene
    Patent number: 6482958
    Abstract: The present invention is concerned with a novel process for the preparation of a hydroxybenzothiophene that is an intermediate for synthesizing pharmaceutically active substances, e.g. 5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-7-benzothiophenylmethyl]-2,4-thiazolidinedione and the corresponding sodium salt which are useful in the treatment of diabetes.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: November 19, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Junghans, Michelangelo Scalone, Thomas Albert Zeibig
  • Methods for the preparation of 4-hydroxy benzothiophene
    Patent number: 6437144
    Abstract: The present invention is concerned with a novel process for the preparation of the hydroxybenzothiophene of formula I comprising cyclocarbonylation of a compound of formula II wherein Y is as defined in the specification, followed by saponification. The compound of Formula I is a building block of pharmaceutically active substances, e.g. 5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-7-benzothiophenylmethyl]-2,4-thiazolidinedione and the corresponding sodium salt which are from agents useful in the treatment of diabetes.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: August 20, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Junghans, Michelangelo Scalone, Thomas Albert Zeibig
  • Methods for the preparation of 4-hydroxy benzothiophene
    Publication number: 20020077488
    Abstract: The present invention is concerned with a novel process for the preparation of a hydroxybenzothiophene that is an intermediate for synthesizing pharmaceutically active substances, e.g. 5- [4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-7-benzothiophenylmethyl]-2,4-thiazolidinedione and the corresponding sodium salt which are useful in the treatment of diabetes.
    Type: Application
    Filed: November 8, 2001
    Publication date: June 20, 2002
    Inventors: Bernd Junghans, Michelangelo Scalone, Thomas Albert Zeibig
  • Methods for the preparation of 4-hydroxy benzothiophene
    Publication number: 20020010345
    Abstract: The present invention is concerned with a novel process for the preparation of the hydroxybenzothiophene of formula I 1
    Type: Application
    Filed: May 8, 2001
    Publication date: January 24, 2002
    Inventors: Bernd Junghans, Michelangelo Scalone, Thomas A. Zeibig
  • Methods for the preparation of 4-hydroxybenzothiophene
    Patent number: 6291685
    Abstract: The present invention is concerned with a novel process for the preparation of the hydroxybenzothiophene of formula I comprising cyclocarbonylation of a compound of formula II wherein Y is as defined in the specification, followed by saponification. The compound of Formula I is a building block of pharmaceutically active substances, e.g. 5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-7-benzothiophenylmethyl]-2,4-thiazolidinedione and the corresponding sodium salt which are from agents useful in the treatment of diabetes.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: September 18, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Junghans, Michelangelo Scalone, Thomas Albert Zeibig