Patents by Inventor Bernd Krause
Bernd Krause has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11974966Abstract: A medical product includes a bladder, a filtration device, and a sterile product concentrate. The bladder has a perimeter seal and defining a sterile chamber. The filtration device includes a stem and a filter membrane disposed in line with the stem. The stem extends through the perimeter seal and has an inlet end accessible from outside of the perimeter seal and an outlet end in fluid communication with the sterile chamber. The filter membrane can have a nominal pore size in a range of approximately 0.1 ?m to approximately 0.5 ?m, wherein the filter membrane is shaped as a hollow fiber with a wall and pores residing in the wall of the fiber. The sterile product concentrate is disposed in the sterile chamber and adapted to be reconstituted by the introduction of a pharmaceutical fluid into the chamber through the filtration device.Type: GrantFiled: July 12, 2018Date of Patent: May 7, 2024Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: David Filiberto Schuck, Karl Hans Cazzini, Yuanpang Samuel Ding, Ying-Cheng Lo, Grant Anthony Bomgaars, Thomas Edward Dudar, Mark Edward Pasmore, Bernd Krause, Michael Joseph Sadowski, Anastasios Hristakos, Joseph Vincent Ranalletta
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Publication number: 20240075433Abstract: The present disclosure relates to an anticoagulant-coated microporous hollow fiber membrane showing reduced thrombogenicity. The disclosure further relates to a method for producing the membrane and a filtration and/or diffusion device comprising the membrane.Type: ApplicationFiled: October 4, 2021Publication date: March 7, 2024Inventors: Matthias WESSLING, Michael ALDERS, Ilka ROSE, Michael KATHER, Ralf MENDA, Bernd KRAUSE, Markus STORR, Martin REMPFER, Vivian Stefan KURBEL
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Publication number: 20240050907Abstract: The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.Type: ApplicationFiled: May 4, 2023Publication date: February 15, 2024Inventors: Adriana BOSCHETTI-DE-FIERRO, Manuel VOIGT, Bernd KRAUSE, Markus HORNUNG, Markus STORR, Heinrich BEHR, Werner BECK, Carina ZWEIGART, Reinhold BUCK, Philipp HERBST, Joachim LOERCHER, Arnd WOCHNER
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Patent number: 11833108Abstract: A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.Type: GrantFiled: July 12, 2018Date of Patent: December 5, 2023Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Mark Joseph Doty, Christine L. Rebbeck, Sydney Jean Cope, William Spencer Hurst, Grant Anthony Bomgaars, Yuanpang Samuel Ding, Thomas Edward Dudar, Ying-Cheng Lo, Mark Edward Pasmore, Michael Joseph Sadowski, Anastasios Hristakos, Joseph Vincent Ranalletta, Bernd Krause
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Patent number: 11759395Abstract: A system for reconstituting and sterilizing a concentrate includes a mixing container, a filtration device, and a product bag. The a mixing container has an inlet port and outlet port in fluid communication with a mixing chamber disposed between the inlet port and the outlet port. The mixing chamber is adapted to contain a product concentrate. The filtration device has an inlet and an outlet, the inlet of the filtration device coupled to the outlet port of the mixing container. The filtration device includes a filter membrane with a nominal pore size in a range of approximately 0.1 ?m to approximately 0.5 ?m. The product bag has an inlet port coupled to the outlet of the filtration device, and has a bladder defining an empty sterile chamber for receiving sterilized and reconstituted product resulting from mixing a diluent with a product concentrate in the mixing chamber to obtain a mixture then introduced through the filtration device to obtain the reconstituted and sterilized product.Type: GrantFiled: March 22, 2022Date of Patent: September 19, 2023Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Yuanpang Samuel Ding, Ying-Cheng Lo, Jacob Daniel Rivett, Grant Anthony Bomgaars, Thomas Edward Dudar, Mark Edward Pasmore, Michael Joseph Sadowski, Anastasios Hristakos, Joseph Vincent Ranalletta, Bernd Krause
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Publication number: 20230271146Abstract: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.Type: ApplicationFiled: May 4, 2023Publication date: August 31, 2023Inventors: Markus HORNUNG, Bernd KRAUSE, Markus STORR, Philipp HERBST, Arnd WOCHNER, Adriana BOSCHETTI-DE-FIERRO, Manuel VOIGT, Carina ZWEIGART, Joachim LOERCHER, Reinhold BUCK, Heinrich BEHR, Werner BECK
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Patent number: 11666868Abstract: The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.Type: GrantFiled: February 1, 2022Date of Patent: June 6, 2023Assignee: GAMBRO LUNDIA ABInventors: Adriana Boschetti-De-Fierro, Manuel Voigt, Bernd Krause, Markus Hornung, Markus Storr, Heinrich Behr, Werner Beck, Carina Zweigart, Reinhold Buck, Philipp Herbst, Joachim Loercher, Arnd Wochner
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Patent number: 11666869Abstract: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.Type: GrantFiled: February 1, 2022Date of Patent: June 6, 2023Assignee: GAMBRO LUNDIA ABInventors: Markus Hornung, Bernd Krause, Markus Storr, Philipp Herbst, Arnd Wochner, Adriana Boschetti-De-Fierro, Manuel Voigt, Carina Zweigart, Joachim Loercher, Reinhold Buck, Heinrich Behr, Werner Beck
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Patent number: 11623773Abstract: A method of providing a plurality of filled product bags of sterile fluid includes positioning a bag assembly onto a filling machine. The bag assembly includes a tube, a filter assembly, bladders, and stems. A stem is attached to a bladder, forms a fluid passageway, fluidly connects to the tube, and provides fluid communication into the bladders. The method includes fluidly coupling an inlet of the filter assembly to a connection line in fluid communication with a fluid source, and filling the bag assembly with a fluid. Filling the bag assembly includes passing the fluid through the filter assembly, the fluid passageway, and into the bladder. The method includes sealing the fluid passageway at a location between the tube and the bladders. The method includes cutting the stem to form a partially filled product bag having the sealed passageway. The method includes performing an integrity test on the filter assembly.Type: GrantFiled: May 21, 2021Date of Patent: April 11, 2023Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Grant Anthony Bomgaars, Joseph Vincent Ranalletta, Yuanpang Samuel Ding, Ying-Cheng Lo, Mark Edward Pasmore, Michael Joseph Sadowski, Anastasios Hristakos, Thomas Edward Dudar, Bernd Krause
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Patent number: 11596902Abstract: The invention relates to a membrane which can be used for cultivating adherent or suspension cells, in particular adherent cells, wherein said membrane allows for the adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma- or beta-rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. The invention further relates to a method for preparing said irradiated membrane which can be used for the cultivation of cells, in particular adherent cells, and to methods of using such a membrane for the cultivation of cells, in particular adherent cells.Type: GrantFiled: March 2, 2021Date of Patent: March 7, 2023Assignee: GAMBRO LUNDIA ABInventors: Bernd Krause, Markus Neubauer, Joachim Loercher
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Publication number: 20230054094Abstract: The present disclosure relates to hollow fiber membrane filtration devices for the production of ready-to-use dialysis fluid by forward osmosis, and a cost-efficient and simple method and system for preparing ready-to-use dialysis fluid from raw water and liquid dialysis concentrate by forward osmosis.Type: ApplicationFiled: July 20, 2020Publication date: February 23, 2023Inventors: Tao HE, Shuwei ZHAO, Pengjia DOU, Jianfeng SONG, Markus STORR, Bernd KRAUSE
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Patent number: 11564867Abstract: A sterile solution product bag includes sterilization grade filter integrated directly into the product bag such that microbial and particulate matter filtration can be performed using the filter directly at the point of fill. The filter can include a hollow fiber filter membrane contained in a stem connected to a bladder of the product bag.Type: GrantFiled: December 11, 2019Date of Patent: January 31, 2023Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Grant Anthony Bomgaars, Bernd Krause, Mark Edward Pasmore, Michael Joseph Sadowski, Yuanpang Samuel Ding, Ying-Cheng Lo, Joseph Vincent Ranalletta
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Patent number: 11547797Abstract: A syringe system includes a syringe and a filtration device connected to the syringe for sterilizing and introducing fluid into the syringe. The syringe includes a syringe barrel having a proximal end defining a barrel opening, a distal end defining a delivery opening, a bore extending between the proximal end and the distal end, and a stopper disposed in the bore of the syringe barrel. The filtration device has an inlet and an outlet coupled in fluid communication with the delivery opening at the distal end of the syringe barrel. The filtration device includes a stem and a filter membrane disposed in line with the stem. The filter membrane optionally has a plurality of pores each with a nominal pore size in a range of approximately 0.1 ?m to approximately 0.5 ?m such that a pharmaceutical fluid can be introduced as a sterilized pharmaceutical fluid into the bore of the syringe barrel by passing through the filtration device.Type: GrantFiled: July 12, 2018Date of Patent: January 10, 2023Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Yuanpang Samuel Ding, Marc Steven Minkus, Ying-Cheng Lo, Mark Joseph Doty, Thomas Edward Dudar, Grant Anthony Bomgaars, Mark Edward Pasmore, Michael Joseph Sadowski, Anastasios Hristakos, Bernd Krause, Joseph Vincent Ranalletta
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Patent number: 11517855Abstract: The present disclosure relates to an artificial, extracorporeal system for supporting the function of the liver of a patient suffering from liver failure, which is characterized in that it comprises a first high-flux or high cut-off hollow fiber membrane dialyzer which is perfused on the lumen side with the patient's blood and wherein a buffered aqueous solution comprising human serum albumin is passed in a continuous flow through the filtrate space of said first dialyzer, a second hollow fiber membrane dialyzer which removes water-soluble substances from the dialysate of said first dialyzer, and a third, integrated hollow fiber membrane dialyzer which is perfused with the retentate of second hemodialyzer and which allows the passage of certain amounts of albumin over the membrane wall into the filtrate space which is populated with adsorbent material. The system can be used for the treatment of acute liver failure and acute-on-chronic liver failure.Type: GrantFiled: September 5, 2017Date of Patent: December 6, 2022Assignee: GAMBRO LUNDIA ABInventors: Ralf Flieg, Bernd Krause, Markus Storr
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Patent number: 11511009Abstract: A product bag includes a bladder and an elongated filtration device. The bladder includes opposing first and second film layers defining a product chamber. The first and second film layers are sealed together along a perimeter seal extending along at least a portion of a perimeter of the bladder. The elongated filtration device includes a housing, a filtration membrane disposed in the housing, an inlet adapted for receiving a fluid to be filtered, and an outlet in fluid communication with the product chamber. A majority of the elongated filtration device is embedded between the first and second film layers of the perimeter seal of the bladder to provide for a compact form factor.Type: GrantFiled: July 12, 2018Date of Patent: November 29, 2022Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: William Spencer Hurst, Steven Clarence Jepson, Grant Anthony Bomgaars, Yuanpang Samuel Ding, Thomas Edward Dudar, Ying-Cheng Lo, Bernd Krause, Mark Edward Pasmore, Michael Joseph Sadowski, Anastasios Hristakos, Joseph Vincent Ranalletta
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Patent number: 11478757Abstract: A system for liver dialysis makes use of a high cut-off hemodialysis membrane for removing water-soluble and protein-bound toxins from the blood of a person in need. A high cut-off hollow fiber hemodialysis membrane has improved potential to remove albumin-bound toxins and inflammatory mediators.Type: GrantFiled: April 13, 2011Date of Patent: October 25, 2022Assignee: GAMBRO LUNDIA ABInventors: Markus Storr, Bernd Krause, Hermann Goehl, Thomas Ertl, Alexander Gekeler
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Publication number: 20220211579Abstract: A system for reconstituting and sterilizing a concentrate includes a mixing container, a filtration device, and a product bag. The a mixing container has an inlet port and outlet port in fluid communication with a mixing chamber disposed between the inlet port and the outlet port. The mixing chamber is adapted to contain a product concentrate. The filtration device has an inlet and an outlet, the inlet of the filtration device coupled to the outlet port of the mixing container. The filtration device includes a filter membrane with a nominal pore size in a range of approximately 0.1 ?m to approximately 0.5 ?m. The product bag has an inlet port coupled to the outlet of the filtration device, and has a bladder defining an empty sterile chamber for receiving sterilized and reconstituted product resulting from mixing a diluent with a product concentrate in the mixing chamber to obtain a mixture then introduced through the filtration device to obtain the reconstituted and sterilized product.Type: ApplicationFiled: March 22, 2022Publication date: July 7, 2022Inventors: Yuanpang Samuel Ding, Ying-Cheng Lo, Jacob Daniel Rivett, Grant Anthony Bomgaars, Thomas Edward Dudar, Mark Edward Pasmore, Michael Joseph Sadowski, Anastasios Hristakos, Joseph Vincent Ranalletta, Bernd Krause
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Publication number: 20220152563Abstract: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.Type: ApplicationFiled: February 1, 2022Publication date: May 19, 2022Inventors: Markus HORNUNG, Bernd KRAUSE, Markus STORR, Philipp HERBST, Arnd WOCHNER, Adriana BOSCHETTI-DE-FIERRO, Manuel VOIGT, Carina ZWEIGART, Joachim LOERCHER, Reinhold BUCK, Heinrich BEHR, Werner BECK
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Publication number: 20220152562Abstract: The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.Type: ApplicationFiled: February 1, 2022Publication date: May 19, 2022Inventors: Adriana BOSCHETTI-DE-FIERRO, Manuel VOIGT, Bernd KRAUSE, Markus HORNUNG, Markus STORR, Heinrich BEHR, Werner BECK, Carina ZWEIGART, Reinhold BUCK, Philipp HERBST, Joachim LOERCHER, Arnd WOCHNER
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Publication number: 20220143320Abstract: The invention relates to a dispenser of a sealant for hemostasis comprising a container configured to receive a fibrinogen solution and an activation compartment being situated downstream of the container and comprising a functionalized support to which a coagulation factor, preferably thrombin, is immobilized, such that upon dispensing the fibrinogen solution it passes through the activation compartment, thereby generating and dispensing polymerizing fibrin as a sealant. The invention further relates to a support, exchangeable tip and a kit for the dispenser as well as to methods and uses of the dispenser or components thereof for dispensing a sealant to a desired site.Type: ApplicationFiled: March 6, 2020Publication date: May 12, 2022Inventors: Jan SWARTJES, Stefanie VOTTELER, Markus STORR, Bernd KRAUSE