Abstract: The present disclosure relates to wearable injection devices that comprise flexible elements. Exemplary devices can comprise flexible reservoirs, flexible housings, and flexible metering mechanisms. The flexible elements of the present disclosure provide improved wearable injection devices with small heights, low profiles, and streamlined, flexible cases that can withstand impact without experiencing adverse performance effects or tearing off of the patient.

Abstract: Implementations of the present disclosure are directed to an injection device that includes a medicament reservoir, a stopper including a rigid core and an ultrasound probe disposed in a housing, the ultrasound probe configured to transmit an emitted ultrasound signal through the rigid core along a longitudinal direction of the rigid core into the medicament reservoir and to receive an ultrasound signal generated by reflections of the emitted ultrasound signal, the reflections including at least a reflection from a distal end of the medicament reservoir, a control component configured to be electronically coupled with the ultrasound probe and to process the ultrasound signal to generate injection device data, and an antenna configured to be electronically coupled with the control component and to transmit the injection device data to an external computing device.

Abstract: Implementations of the present disclosure are directed to an injection device (102) that includes a medicament reservoir (103), a stopper (105) including a rigid core (125) and an ultrasound probe (122) disposed in a housing, the ultrasound probe configured to transmit an emitted ultrasound signal through the rigid core along a longitudinal direction of the rigid core into the medicament reservoir and to receive an ultrasound signal generated by reflections of the emitted ultrasound signal, the reflections including at least a reflection from a distal end of the medicament reservoir, a control component (124a) configured to be electronically coupled with the ultrasound probe and to process the ultrasound signal to generate injection device data, and an antenna (124c) configured to be electronically coupled with the control component and to transmit the injection device data to an external computing device (104).

Abstract: Embodiments of the present disclosure are directed to conserving energy of an injection device that includes an energy source, an electronic component configured to be electrically decoupled from the energy source, a priming component configured to generate a trigger, and a mechanism attached to the priming component and configured to perform operations comprising in response to receiving the trigger, electrically coupling the energy source to the electronic component.

Abstract: Embodiments of the present disclosure are directed to conserving energy of an injection device that includes an energy source, an electronic component configured to be electrically decoupled from the energy source, a priming component configured to generate a trigger, and a mechanism attached to the priming component and configured to perform operations comprising in response to receiving the trigger, electrically coupling the energy source to the electronic component.

Abstract: The present disclosure relates to a drug delivery system and to a drug delivery device, the drug delivery device comprising: a receptacle to accommodate a drug container, wherein the drug container is provided with a container identification, the container identification being at least indicative of a content of the drug container, a container identification arrangement configured to detect and/or to identify the container identification, a delivery device interface configured to transmit uplink data to a communication device, wherein the uplink data contains at least the container identification obtainable from the container identification arrangement and wherein the delivery device interface is configured to receive downlink data from the communication device, and a drive mechanism operably engageable with the drug container and configured to expel a dose of the drug from the drug container on the basis of the downlink data received from the delivery device interface.

Abstract: The disclosure provides a two-chamber carpule comprising two-chambers adapted to be joined together. Each chamber is adapted to contain a medicament component. The carpule further comprises a bevel arranged on a circumference of at least one of the chambers in a transition area. The bevel extends from one chamber to the other chamber.

Abstract: A stopper for use in a cartridge or syringe of a medical device [SL6]is configured to be disposed within a container closure system. The stopper comprises a shell comprising a closed end and an open end with sidewalls extending between the closed end and the open end along a longitudinal axis of the shell. The open end defines a cavity and the sidewalls define an exterior surface sized and shaped to fit inside the container closure system. An insert is configured to be inserted into the cavity, receive a force from a plunger rod, and distribute the force to the shell in order to advance the shell into the container closure system. The closed end of the shell in the cavity defining a convex surface configured to be contacted and deflected by the insert upon insertion into the cavity includes an elastic and/or plastic deformable material.

Abstract: Implementations of the present disclosure are directed to an injection device (102) that includes a medicament reservoir (103), a stopper (105) including a rigid core (125) and an ultrasound probe (122) disposed in a housing, the ultrasound probe configured to transmit an emitted ultrasound signal through the rigid core along a longitudinal direction of the rigid core into the medicament reservoir and to receive an ultrasound signal generated by reflections of the emitted ultrasound signal, the reflections including at least a reflection from a distal end of the medicament reservoir, a control component (124a) configured to be electronically coupled with the ultrasound probe and to process the ultrasound signal to generate injection device data, and an antenna (124c) configured to be electronically coupled with the control component and to transmit the injection device data to an external computing device (104).

Abstract: A method for operating a magnetic resonance device is provided. The magnetic resonance device includes a component that has an operating limit in relation to a state parameter. The component uses a protocol to record magnetic resonance data. The protocol includes a magnetic resonance sequence and is described by protocol parameters. A protocol parameter set that, in relation to a protocol section, allows the protocol section to be repeated as often as desired without exceeding the operating limit is provided or determined. The method includes receiving a boost parameter from a user interface. At least for the protocol section, adaptation parameters are determined at least partially automatically based on the boost parameter, such that the desired number of repetitions described by the boost parameter is established while complying with the operating limit. Magnetic resonance data is recorded with the protocol using the determined adaptation parameters.

Abstract: Embodiments of the present disclosure are directed to conserving energy of an injection device that includes an energy source, an electronic component configured to be electrically decoupled from the energy source, a priming component configured to generate a trigger, and a mechanism attached to the priming component and configured to perform operations comprising in response to receiving the trigger, electrically coupling the energy source to the electronic component.

Abstract: The disclosure provides a two-chamber carpule comprising two-chambers adapted to be joined together. Each chamber is adapted to contain a medicament component. The carpule further comprises a bevel arranged on a circumference of at least one of the chambers in a transition area. The bevel extends from one chamber to the other chamber.

Abstract: In a magnetic resonance apparatus and an operating method therefore, a data acquisition sequence for operating the apparatus is repeatedly reviewed in a number of ascertainment passes executed in a processor, each ascertainment pass involving a calculation step, and in each calculation step a determination is made as to other respective values of data elements used in a previous calculation step have changed. If no change has occurred, a re-calculation in the current calculation step is not implemented, thereby reducing the time and computing capacity that are needed to generate a final data acquisition sequence.

Abstract: In a method for operating a medical imaging examination apparatus having multiple subsystems controlled by a control computer in a scan sequence, a control protocol for the scan is provided to the control computer, which determines sequence control data for the control protocol that define different functional subsequences of the scan, with different effective volumes assigned to each functional subsequence. Current ambient conditions of the apparatus are determined that are decisive for the determined relevant sequence control data and associated effective volumes. Control signals for the scan are determined from the sequence control data, the effective volumes and the current ambient conditions determined that optimize the functional subsequences of the scan.

Abstract: In a method for operating a medical imaging apparatus having subsystems, a control protocol assigned to a scan sequence to be performed is provided to a control computer that determines sequence control data for the control protocol, which define different functional subsequences of the scan sequence. Different effective volumes are assigned to each functional subsequence, and current ambient conditions of the apparatus are determined for the sequence control data and associated effective volumes, for a series of states of physiological processes that occur during the scan sequence. Control signals for the scan sequence are determined from the sequence control data, the effective volumes and the current ambient conditions per observed state, that optimize the functional subsequences of the scan sequence locally.

Abstract: In a method for operating a medical imaging apparatus having multiple subsystems, a control protocol assigned to a scan sequence to be performed is provided to a control computer that determines sequence control data for the control protocol, which define different functional subsequences of the scan sequence. Different effective volumes are assigned to each functional subsequence, and current ambient conditions of the apparatus are determined for the sequence control data and associated effective volumes. Control signals for the scan sequence are determined from the sequence control data, the effective volumes and the current ambient conditions that optimize the functional subsequences of the scan sequence locally, at least with regard to a sub-region of the respective effective volumes.

Abstract: In a method for operating a medical imaging examination apparatus having multiple subsystems, current ambient conditions in a scan volume of the apparatus are determined and stored in a global ambient condition parameter set. A control computer starts a scan sequence according to a selected scan protocol, and sequence control data that define different functional sub-sequences for the respective subsystems are provided to the control computer. Different effective volumes are assigned to each functional sub-sequence, and respective current sub-regions in the effective volume associated with the respective sub-sequence are determined, in which a volume optimization is to take place. Control signals for the scan sequence are calculated using the sequence control data, the global ambient condition parameter set, and the determined current sub-regions of the affected volumes, in order to optimize the functional sub-sequences at least with regard to the current sub-region of the assigned effective volume.

Abstract: In a method for operating a medical imaging apparatus having subsystems, a control protocol assigned to a scan sequence to be performed is provided to a control computer that determines sequence control data for the control protocol, which define different functional subsequences of the scan sequence. Different effective volumes are assigned to each functional subsequence, and current ambient conditions of the apparatus are determined for the sequence control data and associated effective volumes, for a series of states of physiological processes that occur during the scan sequence. Control signals for the scan sequence are determined from the sequence control data, the effective volumes and the current ambient conditions per observed state, that optimize the functional subsequences of the scan sequence locally.

Abstract: In a method for determining time windows in a scan sequence, in which values of setting parameters of a scan can be changed during a current scan without adversely affecting the scan data obtained with the scan, comprising the following a scan sequence is loaded into a control computer, that then determines the time windows in the scan sequence in which values of setting parameters can be changed during a current scan, on the basis of an analysis of useful coherences in the scan sequence. The determined time windows are stored or processed so as to be available to operate an imaging apparatus to execute the scan sequence.

Abstract: The invention relates to a pharmaceutical composition comprising methyl (2R.3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable acidic reacting compound or to an aqueous solution or dispersion of the composition as well as a process for the preparation of the same, methods of using such compositions to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.