Patents by Inventor Bernd Kuhn
Bernd Kuhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12281124Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: GrantFiled: September 26, 2023Date of Patent: April 22, 2025Assignee: Hoffmann-La Roche Inc.Inventors: Charles Bell, Joerg Benz, Luca Gobbi, Uwe Grether, Katrin Groebke Zbinden, Benoit Hornsperger, Buelent Kocer, Carsten Kroll, Bernd Kuhn, Marius Daniel Rinaldo Lutz, Fionn O'Hara, Hans Richter, Martin Ritter, Didier Rombach, Martin Kuratli
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Publication number: 20250099448Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A and R1 to R4 are as described heroin, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: January 25, 2023Publication date: March 27, 2025Applicant: Hoffmann-La Roche Inc.Inventors: Machoud AMOUSSA, Joerg BENZ, Julie Elisabeth Francoise BLAISING, Jason Jacques DENIZOT, Kallie FRISTON, Rudolf Liun Zaccaria GANZONI, Maude GIROUD, Uwe GRETHER, Benoit HORNSPERGER, Isabelle KAUFMANN, Bernd KUHN, Camiel John LEAKE, Jacopo MARGARINI, Rainer Eugen MARTIN, Fionn Susannah O'HARA, Bernd PUELLMANN, Martin RITTER, Didier ROMBACH, Valerie RUNTZ-SCHMITT, Philipp Claudio SCHMID, Matthias Beat WITTWER
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Patent number: 12248046Abstract: A method for operating a magnetic resonance device is provided. The magnetic resonance device includes a component that has an operating limit in relation to a state parameter. The component uses a protocol to record magnetic resonance data. The protocol includes a magnetic resonance sequence and is described by protocol parameters. A protocol parameter set that, in relation to a protocol section, allows the protocol section to be repeated as often as desired without exceeding the operating limit is provided or determined. The method includes receiving a boost parameter from a user interface. At least for the protocol section, adaptation parameters are determined at least partially automatically based on the boost parameter, such that the desired number of repetitions described by the boost parameter is established while complying with the operating limit. Magnetic resonance data is recorded with the protocol using the determined adaptation parameters.Type: GrantFiled: January 15, 2020Date of Patent: March 11, 2025Assignee: Siemens Healthineers AGInventors: Thorsten Feiweier, Andreas Greiser, David Grodzki, Bernd Kühn, Mathias Nittka, Dominik Paul, Thorsten Speckner
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Publication number: 20250059185Abstract: The invention provides new MAGL inhibitors having the general formula (II)AB(II) wherein the variables are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: December 14, 2022Publication date: February 20, 2025Applicant: Hoffmann-La Roche Inc.Inventors: Joerg BENZ, Maude GIROUD, Uwe GRETHER, Bernd KUHN, Fionn Susannah O'HARA, Matthias Beat WITTWER
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Patent number: 12227504Abstract: The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.Type: GrantFiled: January 24, 2023Date of Patent: February 18, 2025Assignee: C4 Therepeutics, Inc.Inventors: Christopher G. Nasveschuk, Fabian Dey, Annick Goergler, Bernd Kuhn, Roger Norcross, Stephan Roever, Philipp Schmid
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Patent number: 12209091Abstract: The present invention provides compounds which are selective allosteric inhibitors of T790M/L858R, T790M/L858R/C797S, L858R, L858R/C797S containing EGFR mutants, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.Type: GrantFiled: November 25, 2020Date of Patent: January 28, 2025Assignee: Hoffmann-La Roche Inc.Inventors: Martin Duplessis, Annick Goergler, Georg Jaeschke, Buelent Kocer, Bernd Kuhn, Kiel Lazarski, Yanke Liang, Yvonne Alice Nagel, Ulrike Obst Sander, Antonio Ricci, Daniel Rueher, Sandra Steiner
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Publication number: 20240383904Abstract: The invention provides new MAGL inhibitors having the general formula (I) wherein the variables are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: April 11, 2024Publication date: November 21, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Machoud AMOUSSA, Joerg BENZ, Julie Elisabeth Francoise BLAISING, Maude GIROUD, Uwe GRETHER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn Susannah O’HARA, Bernd PUELLMANN, Martin RITTER, Didier ROMBACH, Philipp Claudio SCHMID, Matthias Beat WITTWER
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Publication number: 20240368150Abstract: The present invention provides new bicyclic tetrahydroazepine derivatives having the general formula (I), wherein X, Y, R1, R2, R3, R4, R5, R6, R6a are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using them in the treatment of cancer.Type: ApplicationFiled: February 10, 2022Publication date: November 7, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Adrian BRITSCHGI, Roman HUTTER, Holger KUEHNE, Bernd KUHN, Thomas LUEBBERS, Laetitia Janine MARTIN, Barbara Johanna MUELLER, Juergen WICHMANN, Marco BRANDSTAETTER
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Publication number: 20240270725Abstract: The invention provides new reversible monoacylglycerol lipase (MAGL) inhibitors that are useful for the treatment or prophylaxis of diseases or conditions associated with MAGL. The reversible MAGL inhibitors according to the present invention may also be labeled with radioisotopes and are thus useful for medical imaging, such as positron-emission tomography (PET) and/or autoradiography.Type: ApplicationFiled: March 1, 2024Publication date: August 15, 2024Applicants: Hoffmann-La Roche Inc., Eidgenoessische Technische Hochschule ZuerichInventors: Luca Claudio GOBBI, Uwe Michael GRETHER, Yingfang HE, Bernd KUHN, Linjing MU
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Publication number: 20240217928Abstract: The invention relates to novel compounds having the general formula I wherein R1, R2, R3, R4, R5, R6, R7, W, m and n are as described herein, composition including the compounds and methods of using the compounds.Type: ApplicationFiled: January 25, 2024Publication date: July 4, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Bjoern BARTELS, Karlheinz BAUMANN, Fiona GRUENINGER, Remo HOCHSTRASSER, Bernd KUHN, Federica MORANDI, Emmanuel PINARD
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Publication number: 20240199587Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, X, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: October 20, 2023Publication date: June 20, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Machoud AMOUSSA, Joerg BENZ, Niels Kevin BRIAN, Kallie FRISTON, Maude GIROUD, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Camiel John LEAKE, Rainer E. MARTIN, David Friedrich Erhard NIPPA, Fionn Susannah O’HARA, Bernd PUELLMANN, Hans RICHTER, Martin RITTER, Didier ROMBACH, Philipp Claudio SCHMID, Shounan ZHANG
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Patent number: 11981661Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein B, C, L, X, Y, RL and R3 to R5 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: GrantFiled: September 2, 2021Date of Patent: May 14, 2024Assignee: Hoffmann-La Roche Inc.Inventors: Joerg Benz, Uwe Grether, Benoit Hornsperger, Carsten Kroll, Bernd Kuhn, Rainer E. Martin, Fionn O'Hara, Bernd Puellmann, Hans Richter, Martin Ritter
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Publication number: 20240150373Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: September 26, 2023Publication date: May 9, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Charles BELL, Joerg BENZ, Luca GOBBI, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Buelent KOCER, Carsten KROLL, Bernd KUHN, Marius Daniel Rinaldo LUTZ, Fionn O'HARA, Hans RICHTER, Martin RITTER, Didier ROMBACH, Martin KURATLI
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Publication number: 20230416251Abstract: The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.Type: ApplicationFiled: January 24, 2023Publication date: December 28, 2023Applicant: C4 Therapeutics, Inc.Inventors: Christopher G. Nasveschuk, Fabian Dey, Annick Goergler, Bernd Kuhn, Roger Norcross, Stephan Roever, Philipp Schmid
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Patent number: 11814375Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L1, X, m, n, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: GrantFiled: September 10, 2020Date of Patent: November 14, 2023Assignee: Hoffmann-La Roche Inc.Inventors: Joerg Benz, Luca Gobbi, Uwe Grether, Katrin Groebke Zbinden, Benoit Hornsperger, Carsten Kroll, Bernd Kuhn, Rainer E. Martin, Fionn O'Hara, Bernd Puellmann, Hans Richter, Martin Ritter
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Patent number: 11802133Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: GrantFiled: May 20, 2022Date of Patent: October 31, 2023Assignee: Hoffmann-La Roche Inc.Inventors: Charles Bell, Joerg Benz, Luca Gobbi, Uwe Grether, Katrin Groebke Zbinden, Benoit Hornsperger, Buelent Kocer, Carsten Kroll, Bernd Kuhn, Marius Daniel Rinaldo Lutz, Fionn O'Hara, Hans Richter, Martin Ritter, Didier Rombach, Martin Kuratli
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Publication number: 20230241638Abstract: The present disclosure relates to an applicator device for depositing a lubricant onto an inside surface of a barrel of a medicament container. The applicator device includes a sprayer defining a longitudinal direction and sized for insertion into an interior of the barrel along the longitudinal direction. The sprayer is operable to eject the lubricant. A centering element is connected to the sprayer and operably engageable with the barrel in a predefined position or orientation to align the sprayer relative to the barrel.Type: ApplicationFiled: May 28, 2021Publication date: August 3, 2023Inventor: Bernd Kuhn
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Patent number: 11708354Abstract: The present invention provides compounds which are selective allosteric inhibitors of T790M and C797S containing EGFR mutants, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.Type: GrantFiled: November 24, 2020Date of Patent: July 25, 2023Assignee: Hoffmann-La Roche Inc.Inventors: Martin Duplessis, Georg Jaeschke, Bernd Kuhn, Kiel Lazarski, Yanke Liang, Yvonne Alice Nagel, Antonio Ricci, Daniel Rueher, Sandra Steiner
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Publication number: 20230203056Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein X, Y, Z, A, L, B, and R1 to R3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: February 22, 2023Publication date: June 29, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O'HARA, Hans RICHTER, Martin RITTER, Philipp SCHMID
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Publication number: 20230183224Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1, R2 and R3 are as described herein, pharmaceutically acceptable salts thereof, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: November 22, 2022Publication date: June 15, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Charles BELL, Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Buelent KOCER, Bernd KUHN, Hans RICHTER, Satoshi TSUCHIYA