Patents by Inventor Bernd Kuhn

Bernd Kuhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10471216
    Abstract: An apparatus for recording the amount of medicament ejected from an injection device includes a processor to receive information from a primary sensor and a secondary sensor and a memory. The primary sensor is configured to detect information displayed or generated by said injection device and to generate output corresponding thereto. The secondary sensor is configured to detect ejection of medicament from said injection device. The processor is configured to process the output generated by the primary sensor and to record in the memory information indicative of an amount of medicament ejected from said injection device only when the processor determines, on the basis of information received from the secondary sensor, that more than a predetermined amount of medicament has been ejected.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: November 12, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Bernd Kuhn, Michael Schabbach
  • Patent number: 10471213
    Abstract: A supplemental device for attachment to an injection device, the supplemental device is presented having a processor arrangement; and a quantity determiner for determining a quantity of medicament that has been delivered, wherein the quantity determiner has a sensor arranged to detect movement of a drive screw of the injection device during medicament delivery.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: November 12, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Michael Schabbach, Bernd Kuhn
  • Publication number: 20190308955
    Abstract: The present invention provides compounds which are selective allosteric inhibitors of T790M and C797S containing EGFR mutants, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 10, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Martin Duplessis, Georg Jaeschke, Bernd Kuhn, Kiel Lazarski, Yanke Liang, Yvonne Alice Nagel, Antonio Ricci, Daniel Rueher, Sandra Steiner
  • Patent number: 10435407
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: October 8, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Buettelmann, Buelent Kocer, Bernd Kuhn, Marco Prunotto, Hans Richter, Martin Ritter, Markus Rudolph, Alexander Lee Satz
  • Publication number: 20190262233
    Abstract: The disclosure provides a two-chamber carpule comprising two-chambers adapted to be joined together. Each chamber is adapted to contain a medicament component. The carpule further comprises a bevel arranged on a circumference of at least one of the chambers in a transition area. The bevel extends from one chamber to the other chamber.
    Type: Application
    Filed: February 9, 2017
    Publication date: August 29, 2019
    Inventors: Bernd Kühn, Jörn Möckel, Werner Seiferlein
  • Publication number: 20190257029
    Abstract: The present invention relates to a modified cellulosic fiber that comprises anionic moieties in an amount of more than 0.25 mol/kg of dry fiber and has applied theron a polymeric modifying agent in an amount of from 0.5 wt. % to 5.0 wt. %, based on dry fiber, the polymeric modifying agent comprising cationic moieties with a charge of at least 1.5 meq per gram of polymer and the molar ratio of anionic moieties to cationic moieties contained in the fiber is in the range of from 1:1 to 25:1. The fiber according to the present invention is characterized in that the anionic moieties are incorporated in the fiber and are from carboxymethylcellulose, and that the polymeric modifying agent comprising cationic moieties is selected from the group consisting of polydiallyldimethylammonium chloride (poly-DADMAC), poly(acrylamide-co-diallyldimethylammonium chloride) (PAM-DADMAC) and mixtures thereof. The invention furthermore relates to a nonwoven product or fabric comprising the modified cellulosic fiber. (FIG.
    Type: Application
    Filed: October 27, 2017
    Publication date: August 22, 2019
    Inventors: Jörg Kühn, Ingo Bernt, Walter Roggenstein, Bernd Seger
  • Patent number: 10377719
    Abstract: The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: August 13, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Maude Giroud, Wolfgang Haap, Bernd Kuhn, Rainer E. Martin
  • Publication number: 20190169189
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Application
    Filed: February 4, 2019
    Publication date: June 6, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: BERND BUETTELMANN, BUELENT KOCER, BERND KUHN, MARCO PRUNOTTO, HANS RICHTER, MARTIN RITTER, MARKUS RUDOLPH, ALEXANDER LEE SATZ
  • Patent number: 10239876
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: March 26, 2019
    Assignee: Hoffman La-Roche Inc.
    Inventors: Bernd Buettelmann, Buelent Kocer, Bernd Kuhn, Marco Prunotto, Hans Richter, Martin Ritter, Markus Rudolph, Alexander Lee Satz
  • Publication number: 20190071444
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Application
    Filed: August 7, 2018
    Publication date: March 7, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Bernd Buettelmann, Buelent Kocer, Bernd Kuhn, Marco Prunotto, Hans Richter, Martin Ritter
  • Patent number: 10196721
    Abstract: An iron-chromium-aluminum alloy with improved heat resistance, low chromium vaporization rate and good processability, comprising (in % by mass), 2.0 to 4.5% Al, 12 to 25% Cr, 1.0 to 4% W, 0.25 to 2.0% Nb, 0.05 to 1.2% Si, 0.001 to 0.70% Mn, 0.001 to 0.030% C, 0.0001 to 0.05% Mg, 0.0001 to 0.03% Ca, 0.001 to 0.030% P, max. 0.03% N, max. 0.01% S, remainder iron and the usual melting-related impurities.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: February 5, 2019
    Assignee: VDM Metals International GmbH
    Inventors: Heike Hattendorf, Bernd Kuhn, Thomas Eckardt, Tilmann Beck, Willem Quadakkers, Werner Theisen, Nilofar Nabiran
  • Publication number: 20180362461
    Abstract: The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: August 24, 2018
    Publication date: December 20, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Wolfgang Haap, Bernd Kuhn, Thomas Luebbers, Jens-Uwe Peters
  • Publication number: 20180222866
    Abstract: The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: April 4, 2018
    Publication date: August 9, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Maude GIROUD, Wolfgang HAAP, Bernd KUHN, Rainer E. MARTIN
  • Patent number: 10035804
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R5, A1, A2, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: July 31, 2018
    Assignee: Hoffman-La Roche Inc.
    Inventors: Johannes Aebi, Kurt E. Amrein, Junli Chen, Benoit Hornsperger, Bernd Kuhn, Yongfu Liu, Dongbo Li, Hans Peter Maerki, Rainer E. Martin, Alexander Mayweg, Xuefei Tan, Jun Wu, Jianhua Yu
  • Patent number: 9988390
    Abstract: The present invention relates to compounds having the general formula (Ia) or (Ib), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease, in particular influenza.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 5, 2018
    Inventors: Hans Hilpert, Lukas Kreis, Christian Lerner, Roland Humm, Thorsten Muser, Bernd Kuhn
  • Publication number: 20180148450
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Application
    Filed: December 21, 2017
    Publication date: May 31, 2018
    Applicant: Hoffmann La-Roche Inc.
    Inventors: Bernd BUETTELMANN, Buelent KOCER, Bernd KUHN, Marco PRUNOTTO, Hans RICHTER, Martin RITTER, Markus RUDOLPH, Alexander Lee SATZ
  • Patent number: 9980929
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: May 29, 2018
    Assignee: Hoffman-La Roche Inc.
    Inventors: Benoit Hornsperger, Roberto Iacone, Bernd Kuhn, Hans P. Maerki, Peter Mohr, Michael Reutlinger
  • Publication number: 20170348257
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 22, 2017
    Publication date: December 7, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Benoit Hornsperger, Roberto Iacone, Bernd Kuhn, Hans P. Maerki, Peter Mohr, Michael Reutlinger
  • Patent number: 9809599
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: November 7, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Simona M. Ceccarelli, Aurelia Conte, Holger Kuehne, Bernd Kuhn, Werner Neidhart, Ulrike Obst Sander, Markus Rudolph
  • Patent number: 9796702
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, m and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: October 24, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Kurt Amrein, Benoit Hornsperger, Bernd Kuhn, Yongfu Liu, Hans P. Maerki, Rainer E. Martin, Alexander V. Mayweg, Xuefei Tan, Lisha Wang, Dongbo Li, Jun Wu