Patents by Inventor Bernd Limburg

Bernd Limburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11189056
    Abstract: A method for evaluating the suitability of a mobile device having a camera for performing an analytical measurement based on a color formation reaction. A mobile device is provided and is used to take an image of a reference color field of an object. A color coordinate of pixels of a region of interest within the image is determined and a histogram analysis is performed on a distribution of the color coordinates of the pixels. The width of a color peak within the distribution from the histogram analysis is ascertained and compared with a threshold value to thereby determine suitability of the mobile device for performing the analytical measurement based on the color formation reaction.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: November 30, 2021
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Bernd Limburg, Max Berg
  • Publication number: 20210295515
    Abstract: A method for generating a module configured to determine concentration of an analyte in a sample of a body fluid is disclosed. The method includes providing a first set of measurement data derived from images of one or more test strips indicating a color transformation in response to a body fluid containing an analyte. The images can be recorded by multiple devices with differing cameras, software and/or hardware device configurations for image recording and image data processing. A neural network model can be generated in a machine learning process applying an artificial neural network and a module configured to determine concentration of an analyte in a second sample of a body fluid can be generated. Further, the present disclosure includes a system for generating the module as well as a method and a system for determining concentration of an analyte in a sample of a bodily fluid.
    Type: Application
    Filed: June 9, 2021
    Publication date: September 23, 2021
    Inventors: Max Berg, Fredrik Hailer, Bernd Limburg, Daniel Sieffert, Herbert Wieder, Peter Seelig, Benhur Aysin, Siva Chittajallu
  • Publication number: 20210285888
    Abstract: A method of determining analyte concentration in a body fluid with a mobile device having a camera. A user is prompted to apply body fluid to an optical test strip and then waits a predetermined minimum waiting time. The camera captures an image of part of the test field having the body fluid applied thereto. Analyte concentration is determined based on the image captured. The determination includes estimating a point in time of sample application to the test field by taking into account time-dependent information derived from the image captured using a first color channel of a color space. The determination also estimates the concentration of the analyte by taking into account concentration-dependent information derived from the image using a second color channel of the color space.
    Type: Application
    Filed: May 28, 2021
    Publication date: September 16, 2021
    Inventors: Bernd Limburg, Max Berg, Fredrik Hailer, Volker Tuerck, Daria Skuridina, Irina Ostapenko
  • Patent number: 11120553
    Abstract: A method for evaluating the suitability of a mobile device having a camera for performing an analytical measurement is disclosed. The method includes providing the mobile device and providing a reference object having a predefined spatial extension in a spatial dimension. An image is taken of at least part of the reference object using the camera and is used to derive spatial resolution information that includes one or more numerical values that quantify the capability of the camera to resolve two or more objects in the image. A threshold value based on a minimum number of pixels in the spatial dimension within a region of interest in the image is provided and the spatial resolution information is compared with the threshold value. It is determined from the comparison whether the mobile device is suitable for performing the analytical measurement.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: September 14, 2021
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Bernd Limburg, Max Berg
  • Publication number: 20210255111
    Abstract: A method of performing an analytical measurement based on a color formation reaction in an optical test strip using a mobile device having a camera. In the inventive method, an optical test strip having a test field is provided. A first image of at least part of the test field is captured using the camera with an image acquisition setting of the camera, and the image acquisition setting is locked. A sample of body fluid is applied to the test field and then there is a step of waiting a predetermined minimum amount of time. Then, while the image acquisition setting remains locked, a second image of at least part of the test field is captured using the camera with the same image acquisition setting of the camera used to capture the first image. An analytical measurement result value is then determined by using the first and the second images.
    Type: Application
    Filed: May 5, 2021
    Publication date: August 19, 2021
    Inventors: Bernd Limburg, Max Berg, Fredrik Hailer
  • Publication number: 20210258565
    Abstract: A method of evaluating the suitability of a mobile device for performing an analytical measurement based on a color formation reaction. The capability of the mobile device to have relevant settings of the mobile device controlled by software running on the mobile device is evaluated. The relevant settings pertain to image raw data processing steps to be carried out by the mobile device and may include a color space transformation and a tone mapping transformation. When the evaluation indicates that the mobile device is capable of having the relevant settings controlled by the software, control information indicating that the mobile device is suitable for performing the analytical measurement is provided. When the evaluation indicates that the mobile device is not capable of having the relevant settings controlled by the software, control information indicating that the mobile device is unsuitable for performing the analytical measurement is provided.
    Type: Application
    Filed: May 5, 2021
    Publication date: August 19, 2021
    Inventors: Bernd Limburg, Herbert Wieder, Max Berg, Simon Wetzel, Daniel Sieffert, Fredrik Hailer, Christian Melchinger, Zied Guermazi
  • Patent number: 10984892
    Abstract: Methods are provided for detecting an analyte concentration/presence in a body fluid sample that include providing a set of at least two different evaluation rules, each evaluation rule adapted to derive a set characteristic values from an optical measurement curve, where at least one first characteristic value is derived from at least one first evaluation rule and at least one second characteristic value is derived from at least one second evaluation rule. The methods also include performing at least one multivariate analysis of the at least one first and second characteristic values by using at least one predetermined multivariate evaluation algorithm to derive at least one estimate value for at least one target variable Y of the state variables. The methods also include determining at least one analyte concentration by using the at least one target variable Y. Also provided are computer programs and devices that incorporate the same.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: April 20, 2021
    Inventors: Simon Aigner, Gabriele Chemnitius, Carina Horn, Bernd Limburg, Timo Ottenstein, Wolfgang Petrich, Markus Plum, Christian Ringemann, Markus Serr
  • Publication number: 20210088506
    Abstract: A method of evaluating suitability of lighting conditions for detecting an analyte in a sample using a mobile device camera. A test strip is provided for detecting the analyte. A first image of the test strip is captured while an illumination source of the mobile device is turned off and a second image of the test strip is captured while the illumination source is turned on. A sample is applied to the test strip and the first and second images are compared to thereby determine the difference in lighting conditions between the first image and the second image. The comparison is used to derive information on suitability of the lighting conditions for analyte detection. The lighting conditions are indicated as suitable when a predetermined threshold amount of light intensity used for illumination of the test strip originates from the illumination source.
    Type: Application
    Filed: December 10, 2020
    Publication date: March 25, 2021
    Inventors: Max Berg, Fredrik Hailer, Timo Klein, Bernd Limburg, Christian Melchinger, Volker Tuerck
  • Publication number: 20200386672
    Abstract: A calibration method for calibrating a camera for detecting an analyte in a sample is disclosed. A plurality of different color coordinate systems and a set of test samples are provided. The test samples are applied to test elements that have test fields for producing an optically detectable reaction. Images of the colored test fields are acquired using the camera and color coordinates for the images are generated. The color coordinates that are generated are transformed into a set of measured concentrations by using a set of coding functions. The set of measured concentrations is compared with the known concentrations of the test samples and a best match color coordinate system of the plurality of color coordinate systems is determined. A best match coding function of the plurality of coding functions is also determined.
    Type: Application
    Filed: August 24, 2020
    Publication date: December 10, 2020
    Inventors: Bernd Limburg, Max Berg, Fredrik Hailer
  • Publication number: 20200372680
    Abstract: A method, a mobile device and a kit for performing an analytical measurement are disclosed, wherein outliers are eliminated. In the inventive method, a mobile device having a camera and a test strip for performing a color-change detection reaction are provided. A sample is applied to a test field of the test strip and an image of at least part of the test strip is captured. A region of interest in the image is determined and associated with a first sub-set of pixels. A color distribution is evaluated and outliers are eliminated in the first sub-set of pixels. A sub-region of interest is determined within the region of interest and is associated with a second sub-set of pixels. Mean values of the color distributions of the first sub-set of pixels and the second sub-set of pixels are compared to thereby determine homogeneity information of the image.
    Type: Application
    Filed: August 12, 2020
    Publication date: November 26, 2020
    Inventor: Bernd Limburg
  • Publication number: 20200242769
    Abstract: A method for evaluating the suitability of a mobile device having a camera for performing an analytical measurement is disclosed. The method includes providing the mobile device and providing a reference object having a predefined spatial extension in a spatial dimension. An image is taken of at least part of the reference object using the camera and is used to derive spatial resolution information that includes one or more numerical values that quantify the capability of the camera to resolve two or more objects in the image. A threshold value based on a minimum number of pixels in the spatial dimension within a region of interest in the image is provided and the spatial resolution information is compared with the threshold value. It is determined from the comparison whether the mobile device is suitable for performing the analytical measurement.
    Type: Application
    Filed: April 17, 2020
    Publication date: July 30, 2020
    Inventors: Bernd Limburg, Max Berg
  • Publication number: 20200242809
    Abstract: A method for evaluating the suitability of a mobile device having a camera for performing an analytical measurement based on a color formation reaction. A mobile device is provided and is used to take an image of a reference color field of an object. A color coordinate of pixels of a region of interest within the image is determined and a histogram analysis is performed on a distribution of the color coordinates of the pixels. The width of a color peak within the distribution from the histogram analysis is ascertained and compared with a threshold value to thereby determine suitability of the mobile device for performing the analytical measurement based on the color formation reaction.
    Type: Application
    Filed: April 17, 2020
    Publication date: July 30, 2020
    Inventors: Bernd Limburg, Max Berg
  • Publication number: 20190325992
    Abstract: Methods are provided for detecting an analyte concentration/presence in a body fluid sample that include providing a set of at least two different evaluation rules, each evaluation rule adapted to derive a set characteristic values from an optical measurement curve, where at least one first characteristic value is derived from at least one first evaluation rule and at least one second characteristic value is derived from at least one second evaluation rule. The methods also include performing at least one multivariate analysis of the at least one first and second characteristic values by using at least one predetermined multivariate evaluation algorithm to derive at least one estimate value for at least one target variable Y of the state variables. The methods also include determining at least one analyte concentration by using the at least one target variable Y. Also provided are computer programs and devices that incorporate the same.
    Type: Application
    Filed: July 3, 2019
    Publication date: October 24, 2019
    Inventors: Simon Aigner, Gabriele Chemnitius, Carina Horn, Bernd Limburg, Timo Ottenstein, Wolfgang Petrich, Markus Plum, Christian Ringemann, Markus Serr
  • Publication number: 20150286778
    Abstract: Methods are provided for detecting an analyte concentration/presence in a body fluid sample that include providing a set of at least two different evaluation rules, each evaluation rule adapted to derive a set characteristic values from an optical measurement curve, where at least one first characteristic value is derived from at least one first evaluation rule and at least one second characteristic value is derived from at least one second evaluation rule. The methods also include performing at least one multivariate analysis of the at least one first and second characteristic values by using at least one predetermined multivariate evaluation algorithm to derive at least one estimate value for at least one target variable Y of the state variables. The methods also include determining at least one analyte concentration by using the at least one target variable Y. Also provided are computer programs and devices that incorporate the same.
    Type: Application
    Filed: June 19, 2015
    Publication date: October 8, 2015
    Applicant: Roche Diabetes Care, Inc.
    Inventors: Simon Aigner, Gabriele Chemnitius, Carina Horn, Bernd Limburg, Timo Ottenstein, Wolfgang Petrich, Markus Plum, Christian Ringemann, Markus Serr
  • Patent number: 7396684
    Abstract: The invention relates to a method for quantitatively and/or qualitatively detecting layer thicknesses of biological or chemical molecules by means of ellipsometric measurements. Said molecules are deposited on at least one metal layer by virtue of interactions with a gaseous or liquid medium, whereby said metal layer is provided with an immobilisation layer. A method that can be carried out quickly is provided by including the surface plasmon resonance. Said method is provided with a significantly greater detection sensitivity and can be used not only for qualitatively detecting layers. According to the inventive method, the angle of incidence and/or the frequency of the electromagnetic radiation which is used for the ellipsometric measurements is/are adjusted in such a way that a surface plasmon resonance is produced in the metal layer. The detection sensitivity (? cos ?)/(thickness of the layer to be detected) is adjusted by means of the thickness of the metal layer.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: July 8, 2008
    Assignee: Institut fur Mikrotechnik Mainz GmbH
    Inventors: Wolfgang Ehrfeld, Peter Westphal, Bernd Limburg, Antje Pommereau, Svend Berger
  • Publication number: 20050025676
    Abstract: The invention relates to a method for quantitatively and/or qualitatively detecting layer thicknesses of biological or chemical molecules by means of ellipsometric measurements. Said molecules are deposited on at least one metal layer by virtue of interactions with a gaseous or liquid medium, whereby said metal layer is provided with an immobilisation layer. A method that can be carried out quickly is provided by including the surface plasmon resonance. Said method is provided with a significantly greater detection sensitivity and can be used not only for qualitatively detecting layers. According to the inventive method, the angle of incidence and/or the frequency of the electromagnetic radiation which is used for the ellipsometric measurements is/are adjusted in such a way that a surface plasmon resonance is produced in the metal layer. The detection sensitivity (?cos?)/(thickness of the layer to be detected) is adjusted by means of the thickness of the metal layer.
    Type: Application
    Filed: February 9, 2001
    Publication date: February 3, 2005
    Inventors: Wolfgang Ehrfeld, Peter Westphal, Bernd Limburg, Antje Pommereau, Svend Berger