Patents by Inventor Bernd Loeffler

Bernd Loeffler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

DPP IV INHIBITORS

Publication number: 20070259925

Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

Type: Application

Filed: July 17, 2007

Publication date: November 8, 2007

Inventors: Markus Boehringer, Daniel Hunziker, Holger Kuehne, Bernd Loeffler, Ramakanth Sarabu, Hans Peter Wessel
Crystals of DPP-IV

Publication number: 20070100561

Abstract: The present invention provides a crystal of the extracellular domain of mammalian DPP-IV, wherein the crystal has an orthorhombic space group of P212121 and one homodimer of DPP-IV in the asymmetric unit. Also provided is a co-crystal which includes a ligand bound to the active site of mammalian DPP-IV. The invention permits the identification or design of inhibitor compounds of DPP-IV activity, for use in treatment of type II diabetes.

Type: Application

Filed: December 8, 2006

Publication date: May 3, 2007

Inventors: Michael Hennig, Bernd Loeffler, Ralf Thoma
Modified release compositions for DPP-IV inhibitors

Publication number: 20070098781

Abstract: The present invention refers to pharmaceutical composition comprising a DPP-IV inhibitor.

Type: Application

Filed: August 4, 2006

Publication date: May 3, 2007

Inventors: Bernd Loeffler, Alexander MacDonald, Cynthia Rocha, Eric Worth
Crystals of DPP-IV

Publication number: 20070015269

Abstract: The present invention provides a crystal of the extracellular domain of mammalian DPP-IV, wherein the crystal has an orthorhombic space group of P212121 and one homodimer of DPP-IV in the asymmetric unit. Also provided is a co-crystal which includes a ligand bound to the active site of mammalian DPP-IV. The invention permits the identification or design of inhibitor compounds of DPP-IV activity, for use in treatment of type II diabetes.

Type: Application

Filed: November 25, 2003

Publication date: January 18, 2007

Inventors: Michael Hennig, Bernd Loeffler, Ralf Thoma
4-Aminopiperidine derivatives

Publication number: 20060135561

Abstract: The present invention relates to compounds of the formula (I) wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, non-insulin dependent diabetes mellitus and/or impaired glucose tolerance, obesity, and/or metabolic syndrome or ?-cell protection.

Type: Application

Filed: December 14, 2005

Publication date: June 22, 2006

Inventors: Markus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Loeffler, Thomas Luebbers, Fabienne Ricklin
Aminocycloalkanes as DPP-IV inhibitors

Publication number: 20060135512

Abstract: The present invention relates to compounds of formula (I) wherein R1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

Type: Application

Filed: December 13, 2005

Publication date: June 22, 2006

Inventors: Markus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Loeffler, Hans Marty, Patrizio Mattei, Robert Narquizian
Substituted pyrido [2,1-a] isoquinoline derivatives

Publication number: 20060116393

Abstract: The present invention relates to compounds of formula (I) wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

Type: Application

Filed: November 28, 2005

Publication date: June 1, 2006

Inventors: Markus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Loeffler, Fabienne Ricklin, Hans Wessel
Pyridine and pyrimidine derivatives

Publication number: 20050143405

Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3, R4 and X are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

Type: Application

Filed: January 18, 2005

Publication date: June 30, 2005

Inventors: Markus Boehringer, Bernd Loeffler, Jens-Uwe Peters, Matthias Steger, Peter Weiss
DPP IV inhibitors

Publication number: 20050096348

Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

Type: Application

Filed: December 13, 2004

Publication date: May 5, 2005

Inventors: Markus Boehringer, Daniel Hunziker, Holger Kuehne, Bernd Loeffler, Ramakanth Sarabu, Hans Wessel