Patents by Inventor Bernd Nickel

Bernd Nickel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaryl derivatives and their use as medicaments
    Patent number: 6706722
    Abstract: The invention relates to novel acridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: March 16, 2004
    Assignee: Zentaris AG
    Inventors: Peter Emig, Eckhard Günther, Bernd Nickel, Gerhard Bacher, Silke Baasner, Thomas Beckers, Beate Aue
  • Cyclic indole and heteroindole derivatives and methods for making and using as pharmaceuticals
    Publication number: 20040039197
    Abstract: The invention relates to novel, substituted, fused indole and heteroindole derivatives of the general formula I 1
    Type: Application
    Filed: August 30, 2002
    Publication date: February 26, 2004
    Inventors: Heinz Weinberger, Thomas Beckers, Mathias Schmidt, Silke Baasner, Bernd Nickel
  • Use of dopamine receptor antagonists in palliative tumor therapy
    Patent number: 6696428
    Abstract: The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: February 24, 2004
    Assignee: Zentaris AG
    Inventors: Bernd Nickel, Peter Hilgard, Thomas Klenner, Jürgen Engel
  • Indolyl-3-glyoxylic acid derivatives having therapeutically valuable properties
    Patent number: 6693119
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general Formula I and to pharmaceutical compositions having antitumor action.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: February 17, 2004
    Assignee: Baxter Healthcare SA
    Inventors: Bernd Nickel, Gerald Bacher, Thomas Klenner, Thomas Beckers, Peter Emig, Jürgen Engel, Erik Bruyneel, Günter Kamp, Kirsten Peters
  • Heteroary1 derivatives and their use as medicaments
    Patent number: 6638935
    Abstract: The invention relates to novel pyridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: October 28, 2003
    Assignee: Zentaris AG
    Inventors: Peter Emig, Eckhard Günther, Bernhard Kutscher, Bernd Nickel, Jürgen Schmidt, Anita Storch
  • Indolyl-3-glyoxylic acid derivatives having antitumor action
    Publication number: 20030195360
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents 1
    Type: Application
    Filed: December 4, 2002
    Publication date: October 16, 2003
    Applicant: ASTA Medica Aktiengesellschaft
    Inventors: Bernd Nickel, Istvan Szelenyi, Jurgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Gunther, Kay Brune, Guillaume Le Baut
  • Indolyl-3-glyoxylic acid derivatives having therapeutically valuable properties
    Publication number: 20030114511
    Abstract: The object of the invention is then to widen the field of use of N-substituted indole-3-glyoxylamides and thus to enrich the available pharmaceutical wealth. The possibility of a lower, longer-lasting and better-tolerable medication for the class of substances having antitumor action described in German Patent Application 19814 838.0 should thus be opened up. In particular, the disadvantageous development of resistance, as is known of many antitumor agents, should be circumvented.
    Type: Application
    Filed: January 27, 2000
    Publication date: June 19, 2003
    Inventors: Bernd Nickel, Gerald Bacher, Thomas Klenner, Thomas Beckers, Peter Emig, Jurgen Engel, Erik Bruyneel, Gunter Kamp, Kirsten Peters
  • Use of dopamine receptor antagonists in palliative tumor therapy
    Patent number: 6576624
    Abstract: The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: June 10, 2003
    Assignee: Zentaris AG
    Inventors: Bernd Nickel, Peter Hilgard, Thomas Klenner, Jürgen Engel
  • Novel indole derivatives and their use as medicaments
    Publication number: 20030100597
    Abstract: The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Application
    Filed: July 20, 2001
    Publication date: May 29, 2003
    Inventors: Peter Emig, Gerald Bacher, Dietmar Reichert, Silke Basner, Beate Aue, Bernd Nickel, Eckhard Gnther
  • Pharmaceutical composition comprising ifosfamide and carnitine
    Publication number: 20030040507
    Abstract: The invention relates to the use of a combination of ifosfamide and carnitine, in particular L-carnitine, for the production of tumour pharmaceuticals having decreased side effects. The results show clearly that the side effect produced by ifosfamide (damage to the proximal tubule of the kidney) is antagonized in animals by L-carnitine. It was furthermore possible to show that the antitumour action of ifosfamide is not affected in combination with L-carnitine. The combination also caused no new side effects in the animals.
    Type: Application
    Filed: October 9, 2002
    Publication date: February 27, 2003
    Inventors: Bernd Nickel, Joerg Pohl, Thomas Nolte, Peter Hilgard, Jurgen Engel, J. S. Schlenzig
  • United states patent office
    Publication number: 20030023093
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents 1
    Type: Application
    Filed: March 19, 2001
    Publication date: January 30, 2003
    Applicant: ASTA Medica Aktiengesellschaft
    Inventors: Bernd Nickel, Istvan Szelenyi, Jurgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Gunther, Kay Brune, Guillaume Le Baut
  • Use of dopamine receptor antagonists in palliative tumor therapy
    Publication number: 20030008846
    Abstract: The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.
    Type: Application
    Filed: August 2, 2002
    Publication date: January 9, 2003
    Applicant: Degussa AG
    Inventors: Bernd Nickel, Peter Hilgard, Thomas Klenner, Jurgen Engel
  • Novel heteroaryl derivatives and their use as medicaments
    Publication number: 20020132821
    Abstract: The invention relates to novel acridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Application
    Filed: July 20, 2001
    Publication date: September 19, 2002
    Inventors: Peter Emig, Eckhard Gnther, Bernd Nickel, Gerald Bacher, Silke Baasner, Thomas Beckers, Beate Aue
  • Novel heteroary1 derivatives and their use as medicaments
    Publication number: 20020111354
    Abstract: The invention relates to novel pyridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Application
    Filed: July 20, 2001
    Publication date: August 15, 2002
    Inventors: Peter Emig, Eckhard Gnther, Bernhard Kutscher, Bernd Nickel, J?uuml;rgen Schmidt, Anita Storch
  • Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action
    Patent number: 6432987
    Abstract: The invention relates to novel, substituted N-benzyl-indol-3-ylglyoxylic acid derivatives of the following formula and their use for the treatment of oncoses The invention further relates to their physiologically tolerable acid addition salts and if possible their N-oxides.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: August 13, 2002
    Assignee: Zentaris AG
    Inventors: Eckhard Gunther, Peter Emig, Dietmar Reichert, Guillaume Le Baut, Bernd Nickel, Gerald Bacher
  • Novel heteroaryl derivatives and their use as medicaments
    Publication number: 20020103214
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Application
    Filed: July 20, 2001
    Publication date: August 1, 2002
    Inventors: Peter Emig, Eckhard Gnther, J?uuml;rgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Xanthone compounds, their preparation and use as medicament
    Patent number: 6403636
    Abstract: This invention relates to novel xanthone compounds, their preparation and use as medicament. More particularly this invention is directed to the isolation of the novel xanthone natural product sootepenseone from Dasymaschalon sootepense Craib, Annonaceae, its identification and derivatization, and the use of sootepenseone and its derivatives as anticancer agents.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: June 11, 2002
    Assignee: Zentaris AG
    Inventors: Vichai Reutrakul, Thaiwatchai Santisuk, Gerhard Noessner, Juergen Schmidt, Bernd Nickel, Thomas Klenner, Sebastian Hose
  • Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action
    Publication number: 20010014690
    Abstract: The invention relates to novel, substituted N-benzyl-indol-3-ylglyoxylic acid derivatives of the following formula and their use for the treatment of oncoses 1
    Type: Application
    Filed: December 15, 2000
    Publication date: August 16, 2001
    Inventors: Eckhard Gunter, Peter Emig, Dietmar Reichert, Guillaume Le Baut, Bernd Nickel, Gerald Bacher
  • Indolyl-3-glyoxylic acid derivatives having antitumor action
    Patent number: 6232327
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: May 15, 2001
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Bernd Nickel, Istvan Szelenyi, Jürgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Günther, Kay Brune
  • Use of dopamine receptor antagonists in palliative tumor therapy
    Patent number: 6093704
    Abstract: The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: July 25, 2000
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Bernd Nickel, Peter Hilgard, Thomas Klenner, Jurgen Engel