Abstract: The invention relates to a VHH specifically binding to plasmin. The invention further relates to a compound or a pharmaceutical composition comprising the VHH and to the use thereof in the treatment, prevention or amelioration of a disease or condition characterized by a thrombotic or embolic state.

Abstract: An overvoltage protector having a housing and at least one overvoltage limiter arranged in the housing, especially a gas-filled surge arrester (1), a suppressor diode (2) or a varistor. The functional ability and the state of the overvoltage protector can be controlled during operation by associating a monitoring component with the overvoltage limiter which detects a current (i) flowing over the overvoltage limiter component, and by providing an evaluation unit that evaluates the signal of the monitoring component.

Abstract: The object of the invention is a thermal overload protection device (22) for protecting an electric component (10), in particular an electronic component, wherein the overload protection device (22) has a short-circuit unit (24) for short-circuiting connections (12, 14) of the component (10), and an actuating member (26) actuating the short-circuit unit (24) in a temperature sensitive manner. According to the invention it is provided that the short-circuit unit (24) is attached to a circuit path support (16) in at least one area (28), and is supported in at least another area (30) on the component (10) disposed on the circuit path support (16) via the actuating unit (26), and/or at least one of the circuit paths (18, 20) contacting one of the connections (12, 14) to be short-circuited. The invention further relates to a respective arrangement (36) having a circuit path support (16), at least one component (10) disposed thereupon, and at least one assigned overload protection device (22).

Abstract: An overvoltage protector having a housing and at least one overvoltage limiter arranged in the housing, especially a gas-filled surge arrester (1), a suppressor diode (2) or a varistor. The functional ability and the state of the overvoltage protector can be controlled during operation by associating a monitoring component with the overvoltage limiter which detects a current (i) flowing over the overvoltage limiter component, and by providing an evaluation unit that evaluates the signal of the monitoring component.

Abstract: An overvoltage protector having a housing and at least one overvoltage limiter arranged in the housing, especially a gas-filled surge arrester (1), a suppressor diode (2) or a varistor. The functional ability and the state of the overvoltage protector can be controlled during operation by associating a monitoring component with the overvoltage limiter which detects a current (i) flowing over the overvoltage limiter component, and by providing an evaluation unit that evaluates the signal of the monitoring component.

Abstract: The object of the invention is a thermal overload protection device (22) for protecting an electric component (10), in particular an electronic component, wherein the overload protection device (22) has a short-circuit unit (24) for short-circuiting connections (12, 14) of the component (10), and an actuating member (26) actuating the short-circuit unit (24) in a temperature sensitive manner. According to the invention it is provided that the short-circuit unit (24) is attached to a circuit path support (16) in at least one area (28), and is supported in at least another area (30) on the component (10) disposed on the circuit path support (16) via the actuating unit (26), and/or at least one of the circuit paths (18, 20) contacting one of the connections (12, 14) to be short-circuited. The invention further relates to a respective arrangement (36) having a circuit path support (16), at least one component (10) disposed thereupon, and at least one assigned overload protection device (22).

Abstract: The invention concerns a process for the purification of factor VIII by affinity chromatography characterized in that a biological fluid containing factor VIII is contacted with immobilized cellular von Willebrand factor or a derivative thereof under such conditions that factor VIII is adsorbed to the immobilized von Willebrand factor or derivative thereof, impurities are separated and adsorbed factor VIII is eluted.

Abstract: In order to determine lupus anticoagulant (LA) antibodies in blood, plasma or tissue samples by means of the inhibitory effect of these antibodies on the neutralizing effect of protein C on the blood coagulation system, a defined amount of activated protein C is added to the sample, after incubation the remaining amount of a physiological substrate of protein C or protein S activity in the sample is determined according to known methods and the amount of LA antibodies present is calculated by comparison with a standard containing no LA antibodies. The method according to the present invention can be used to diagnose a predisposition to thrombotic events or disease-dependent risk of thrombosis as well as to monitor a therapy.