Patents by Inventor Bernd Radüchel

Bernd Radüchel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection
    Patent number: 7776896
    Abstract: This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory diseases associated with influenza A viruses, such as for example H5N1 and its mutations. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: August 17, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: William Guilford, Werner Skuballa, Daryl H. Faulds, Monica Kochanny, Wheeseong Lee, Bernd Radüchel
  • Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
    Patent number: 7226578
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Grant
    Filed: October 5, 2004
    Date of Patent: June 5, 2007
    Assignee: Shering aG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
    Patent number: 7211241
    Abstract: Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography imaging.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: May 1, 2007
    Assignee: Schering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Radüchel, Andreas Mühler, Thomas Frenzel
  • Macrocyclic metal complexes and their use for the production of conjugates with biomolecules
    Patent number: 7164016
    Abstract: The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: January 16, 2007
    Assignee: Schering AG
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Günther Michl, Thomas Frenzel, Detlev Sülzle, Hans Bauer, Bernd Radüchel, Hanns-Joachim Weinmann, Heiko Schirmer
  • DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production
    Patent number: 7074387
    Abstract: Compounds of formula I wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as NMR shift reagents.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: July 11, 2006
    Assignee: Schering AG
    Inventors: Heinz Gries, Erich Klieger, Bernd Raduechel, Heribert Schmitt-Willich, Hanns-Joachim Weinmann, Hubert Vogler, Gabriele Schuhmann-Giampieri, Juergen Conrad
  • Galenical formulations
    Publication number: 20060093554
    Abstract: This invention describes new galenical formulations that contain paramagnetic and diamagnetic perfluoroalkyl-containing compounds. The new formulations are suitable as contrast media for nuclear spin tomography.
    Type: Application
    Filed: September 12, 2005
    Publication date: May 4, 2006
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduechel, Peter Mareski, Bernd Misselwitz, Thomas Frenzel, Hanns-Joachim Weinmann
  • Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
    Patent number: 6916461
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: July 12, 2005
    Assignee: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
    Publication number: 20050074409
    Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration<10?3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R1)>10 I/mmol.s) as contrast media in MR imaging for visualization of plaque, lymph nodes, infarcted and necrotic tissue and for independent visualization of necrotic tissue and tumor tissue.
    Type: Application
    Filed: June 2, 2004
    Publication date: April 7, 2005
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
    Patent number: 6861043
    Abstract: Cascade polymer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: March 1, 2005
    Assignee: Schering AG
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Radüchel, Andreas Mühler, Thomas Frenzel
  • Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
    Patent number: 6818203
    Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10−3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s) as contrast media in MR imaging for visualization of plaque, lymph nodes, infarcted and necrotic tissue and for independent visualization of necrotic tissue and tumor tissue.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: November 16, 2004
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
    Patent number: 6676928
    Abstract: Perfluoroalkyl-containing complexes with polar radicals of general formula I (K)1-G-(Z-Rf)m(R)p  (I) in which R means the polar radical, Rf means a perfluorinated carbon chain, K is a metal complex, and Z represents a linker group, are suitable for intravenous lymphography, for tumor diagnosis and for infarction and necrosis imaging.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: January 13, 2004
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Perfluoroalkyl group-containing micelle-forming triiodoaromatic compounds, process for their production and their use as contrast media
    Publication number: 20030236407
    Abstract: The invention relates to new, perfluoroalkyl group-containing triiodoaromatic compounds, process for their production, their use as contrast media for x-ray diagnosis as well as for magnetic resonance diagnosis and magnetic resonance spectroscopy by means of fluorine measurement. Subjects of the invention are also diagnostic agents that contain these new compounds.
    Type: Application
    Filed: February 28, 2003
    Publication date: December 25, 2003
    Applicant: Schering AG
    Inventors: Markus Schafer, Bernd Raduechel, Heribert Miklautz, Franz Maier
  • Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
    Patent number: 6641797
    Abstract: Perfluoroalkyl-containing complexes with sugar radicals of general formula I in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH position, Rf means a perfluorinated carbon chain, K is a metal complex, and Y and Z represent linker groups, are suitable for intravenous lymphography, for tumor diagnosis and for infarction and necrosis imaging.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: November 4, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production
    Patent number: 6565830
    Abstract: Compounds of formula I wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as susceptibility reagents for use in susceptibility imaging.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: May 20, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Erich Klieger, Bernd Radüchel, Heribert Schmitt-Willich, Hanns-Joachim Weinmann, Hubert Vogler, Gabriele Schuhmann-Giampieri, Jürgen Conrad
  • Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
    Publication number: 20030072713
    Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10−3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s) as contrast media in MR imaging for visualization of plaque, lymph nodes, infarcted and necrotic tissue and for independent visualization of necrotic tissue and tumor tissue.
    Type: Application
    Filed: August 10, 2001
    Publication date: April 17, 2003
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Lipophilic metal complexes for necrosis and infarction imaging
    Patent number: 6495118
    Abstract: This invention describes the use of metal complexes that have a plasma protein bond of at least 10% as imaging diagnostic agents for locating an infarction or a necrosis using lasting positive visualization.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: December 17, 2002
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Speck, Ulrich Niedballa, Bernd Radüchel, Hanns Joachim Weinmann, Wolfgang Ebert
  • Metal complexes that contain perfluoroalkly, process for their production and their use in NMR diagnosis
    Patent number: 6468502
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: October 22, 2002
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Perfluoroalkylamides, their production and their use in diagnosis
    Patent number: 6461587
    Abstract: The invention relates to macrocyclic perfluoroalkylamides, their production and their use in diagnosis.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: October 8, 2002
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Detlev Suelzle, Wolfgang Schlecker, Bernd Raduechel, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
    Patent number: 6426059
    Abstract: Cascade polmer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: July 30, 2002
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Radüchel, Andreas Mühler, Thomas Frenzel
  • Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
    Publication number: 20020076379
    Abstract: Perfluoroalkyl-containing complexes with sugar radicals of general formula I 1
    Type: Application
    Filed: August 10, 2001
    Publication date: June 20, 2002
    Applicant: Schering AG
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz