Patents by Inventor Bernd Raduchel

Bernd Raduchel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection
    Patent number: 7776896
    Abstract: This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory diseases associated with influenza A viruses, such as for example H5N1 and its mutations. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: August 17, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: William Guilford, Werner Skuballa, Daryl H. Faulds, Monica Kochanny, Wheeseong Lee, Bernd Radüchel
  • Novel 5-cyano-prostacyclin derivatives as agents for the treatment of autoimmune diseases
    Publication number: 20080242713
    Abstract: This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating autoimmune diseases. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 2, 2008
    Inventors: William Guilford, Werner Skuballa, Daryl H. Faulds, Monica Kochanny, Wheeseong Lee, Bernd Raduchel
  • Novel 5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection
    Publication number: 20080242714
    Abstract: This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory diseases associated with influenza A viruses, such as for example H5N1 and its mutations. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 2, 2008
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: William Guilford, Werner Skuballa, Daryl H. Faulds, Monica Kochanny, Wheeseong Lee, Bernd Raduchel
  • Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
    Patent number: 7226578
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Grant
    Filed: October 5, 2004
    Date of Patent: June 5, 2007
    Assignee: Shering aG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
    Patent number: 7211241
    Abstract: Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography imaging.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: May 1, 2007
    Assignee: Schering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Radüchel, Andreas Mühler, Thomas Frenzel
  • Conjugates of macrocyclic metal complexes with biomolecules and their use for the production of agents for NMR diagnosis and radiodiagnosis as well as radiotherapy
    Publication number: 20070014725
    Abstract: The invention relates to conjugates that consist of macrocyclic metal complexes with biomolecules and their production. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as as agents for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
    Type: Application
    Filed: March 28, 2006
    Publication date: January 18, 2007
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Gunther Michl, Thomas Frenzel, Detlev Sulzle, Hans Bauer, Bernd Raduchel, Hanns-Joachim Weinmann, Heiko Schirmer
  • Macrocyclic metal complexes and their use for the production of conjugates with biomolecules
    Patent number: 7164016
    Abstract: The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: January 16, 2007
    Assignee: Schering AG
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Günther Michl, Thomas Frenzel, Detlev Sülzle, Hans Bauer, Bernd Radüchel, Hanns-Joachim Weinmann, Heiko Schirmer
  • Macrocyclic metal complexes and their use for the production of conjugates with biomolecules
    Publication number: 20070009442
    Abstract: The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
    Type: Application
    Filed: March 28, 2006
    Publication date: January 11, 2007
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Gunther Michl, Thomas Frenzel, Detlev Sulzle, Hans Bauer, Bernd Raduchel, Hanns-Joachim Weinmann, Heiko Schirmer
  • Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
    Patent number: 6916461
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: July 12, 2005
    Assignee: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
    Publication number: 20050147563
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Application
    Filed: October 5, 2004
    Publication date: July 7, 2005
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
    Patent number: 6861043
    Abstract: Cascade polymer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: March 1, 2005
    Assignee: Schering AG
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Radüchel, Andreas Mühler, Thomas Frenzel
  • Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
    Publication number: 20040091426
    Abstract: Cascade polymer complexes that contain
    Type: Application
    Filed: October 17, 2003
    Publication date: May 13, 2004
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Raduchel, Andreas Muhler, Thomas Frenzel
  • Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
    Publication number: 20030232012
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy.
    Type: Application
    Filed: July 18, 2002
    Publication date: December 18, 2003
    Applicant: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Conjugates of macrocyclic metal complexes with biomolecules and their use for the production of agents for NMR diagnosis and radiodiagnosis as well as radiotherapy
    Publication number: 20030206865
    Abstract: The invention relates to conjugates that consist of macrocyclic metal complexes with biomolecules and their production. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as as agents for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
    Type: Application
    Filed: July 19, 2002
    Publication date: November 6, 2003
    Applicant: Schering AG
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Gunther Michl, Thomas Frenzel, Detlev Sulzle, Hans Bauer, Bernd Raduchel, Hans-Joachim Weinmann, Henko Schirmer
  • DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production
    Publication number: 20030202943
    Abstract: Compounds of general formula I 1
    Type: Application
    Filed: March 25, 2003
    Publication date: October 30, 2003
    Applicant: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Erich Klieger, Bernd Raduchel, Heribert Schmitt-Willich, Hanns-Joachim Weinmann, Hubert Vogler, Gabriele Schuhmann-Giampieri, Jurgen Conrad
  • (Ethylene)-(propylene) - triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents
    Publication number: 20030194371
    Abstract: The invention relates to (ethylene)-(propylene)-triaminepentaacetic acid derivatives that are substituted on both the ethylene bridge and the propylene bridge, as well as conjugates of these compounds with biomolecules. The compounds and conjugates are suitable as agents for NMR diagnosis and radiodiagnosis as well as for radiotherapy.
    Type: Application
    Filed: July 10, 2002
    Publication date: October 16, 2003
    Applicant: Schering AG
    Inventors: Lutz Lehmann, Matthias Friebe, Christoph-Stephan Hilger, Ulrich Niedballa, Johannes Platzek, Bernd Raduchel
  • Macrocyclic metal complexes and their use for the production of conjugates with biomolecules
    Publication number: 20030108486
    Abstract: The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
    Type: Application
    Filed: July 19, 2002
    Publication date: June 12, 2003
    Applicant: Schering AG
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Gunther Michl, Thomas Frenzel, Detlev Sulzle, Hans Bauer, Bernd Raduchel, Hanns-Joachim Weinmann, Heiko Schirmer
  • DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production
    Patent number: 6565830
    Abstract: Compounds of formula I wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as susceptibility reagents for use in susceptibility imaging.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: May 20, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Erich Klieger, Bernd Radüchel, Heribert Schmitt-Willich, Hanns-Joachim Weinmann, Hubert Vogler, Gabriele Schuhmann-Giampieri, Jürgen Conrad
  • Lipophilic metal complexes for necrosis and infarction imaging
    Publication number: 20030064026
    Abstract: This invention describes the use of metal complexes that have a plasma protein bond of at least 10% as imaging diagnostic agents for locating an infarction or a necrosis using lasting positive visualization.
    Type: Application
    Filed: October 7, 2002
    Publication date: April 3, 2003
    Applicant: Schering AG
    Inventors: Johannes Platzek, Ulrich Speck, Ulrich Niedballa, Bernd Raduchel, Hanns Weinmann, Wolfgang Ebert
  • Lipophilic metal complexes for necrosis and infarction imaging
    Patent number: 6495118
    Abstract: This invention describes the use of metal complexes that have a plasma protein bond of at least 10% as imaging diagnostic agents for locating an infarction or a necrosis using lasting positive visualization.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: December 17, 2002
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Speck, Ulrich Niedballa, Bernd Radüchel, Hanns Joachim Weinmann, Wolfgang Ebert