Patents by Inventor Bernd Stowasser

Bernd Stowasser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrug derivatives of enzyme inhibitors having hydroxyl groups, a process for preparing them, and their use
    Patent number: 5804559
    Abstract: The invention concerns prodrugs of enzyme inhibitors in which at least one OH-- group in the enzyme inhibitor has been converted into a derivative grouping of the formula III, IV or V: ##STR1## in which the groups R.sup.11 to R.sup.25 and s,l, m, o, q, and r are as defined in the description. Such prodrugs exhibit an improved solubility in water and improved pharmaco-kinetic characteristics.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: September 8, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Karl-Heinz Budt, Bernd Stowasser, Anuschirwan Peyman, Jochen Knolle, Irvin Winkler, Hans Gerd Berscheid
  • Inhibitors of retroviral proteases
    Patent number: 5712417
    Abstract: The present invention relates to compounds of the formula I ##STR1## wherein A, Y, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, l, m and the corresponding radicals labeled with * are defined as stated in the description, a process for their preparation and their use for the inhibition of retroviral proteases.
    Type: Grant
    Filed: July 11, 1994
    Date of Patent: January 27, 1998
    Assignee: Abbott Laboratories
    Inventors: Karl-Heinz Budt, Bernd Stowasser, Dieter Ruppert, Christoph Meichsner, Arnold Paessens, Jutta Hansen, Jochen Knolle
  • Inhibitors of retroviral proteases
    Patent number: 5663139
    Abstract: The present invention relates to a compound of the formula ##STR1## in which A, Q, R.sup.2, R.sup.3 and R.sup.4, and also the corresponding, asterisked radicals, are defined as indicated in the description, to a process for their preparation, and also to their use for inhibiting retroviral proteases.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: September 2, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Bernd Stowasser, Jian-Qi Li, Anuschirwan Peyman, Karl-Heinz Budt
  • Process for the preparation of derivatives of bis(amino-methyl) phosphinic acid
    Patent number: 5510504
    Abstract: A process for the preparation of .alpha.- or .alpha.,.alpha.'-substituted derivatives of the bis(aminomethyl)phosphinic acid of the formula I and their acid or basic salts, ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 are defined as in the description, wherein a bis(aminomethyl)phosphinate is converted into the corresponding bisimine, which is alkylated by R.sup.2 and R.sup.3 in the .alpha.- and/or .alpha.,.alpha.'-position after reaction with a base, and is converted into a compound of the formula I by subsequent treatment with an acid.
    Type: Grant
    Filed: January 4, 1995
    Date of Patent: April 23, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Anuschirwan Peyman, Karl-Heinz Budt, Jorg Spanig, Jian-Qi Li, Bernd Stowasser