Abstract: An inhibitor of IL-38 is useful for treating and/or preventing cancer in a subject. A pharmaceutical composition can include an inhibitor of IL-38. A method for treating and/or preventing cancer is carried out by administering an inhibitor of IL-38 in a therapeutically effective amount. Another method is useful for identifying an inhibitor of IL-38.

Abstract: An inhibitor of IL-38 is useful for treating and/or preventing cancer in a subject. A pharmaceutical composition can include an inhibitor of IL-38. A method for treating and/or preventing cancer is carried out by administering an inhibitor of IL-38 in a therapeutically effective amount. Another method is useful for identifying an inhibitor of IL-38.

Abstract: The present invention pertains to an N-terminally truncated interleukin (IL)-38 protein, or functional variants thereof, as well as to nucleic acids and vectors encoding the truncated IL-38 peptide and recombinant cells comprising these nucleic acids or vectors. The invention shows that IL-38 is N-terminally processed and that the truncated version of the cytokine acts as an antagonist of immune activation in macrophages. This indicates a use of the truncated cytokine in the treatment and prevention of autoimmune disorders. The invention further provides pharmaceutical compositions comprising the truncated IL-38 protein, and method for screening modulators of the function of truncated IL-38.

Abstract: The invention relates to a fuel cell or fuel cell module (12) consisting of a plurality of single cells (7), all of which have the same dimensions, i.e. in terms of the length, width and height. Said cells have an optimal constructions, as the supply lines are associated with and connected to a cooling and medium module (40). Said cooling and medium module (40) is only used to provide secondary functional chambers (41), (42) or functional planes and to form the stack. In addition, either the hydrogen electrode (5), (5?) or the oxygen electrode (6), (6?) of the neighbouring single cell (7) is situated on both sides of a respective cooling and medium module (40). This obviates the need for all types of bipolar plates, permitting for example thin metal sheets (90), (91) to be used. Said sheets have gas inlets (73) and gas outlets (74) for the oxygen feed (70) and the hydrogen feed (71), allowing the separate conduction of both the process gases and the coolant.

Abstract: The invention relates to a fuel cell or fuel cell module (12) consisting of a plurality of single cells (7), all of which have the same dimensions, i.e. in terms of the length, width and height. Said cells have an optimal constructions, as the supply lines are associated with and connected to a cooling and medium module (40). Said cooling and medium module (40) is only used to provide secondary functional chambers (41), (42) or functional planes and to form the stack. In addition, either the hydrogen electrode (5), (5?) or the oxygen electrode (6), (6?) of the neighbouring single cell (7) is situated on both sides of a respective cooling and medium module (40). This obviates the need for all types of bipolar plates, permitting for example thin metal sheets (90), (91) to be used. Said sheets have gas inlets (73) and gas outlets (74) for the oxygen feed (70) and the hydrogen feed (71), allowing the separate conduction of both the process gases and the coolant.