Abstract: A bioprocessing installation comprising a reservoir tank, one or more fluid lines, one or more receiving containers and an electronic control unit. The fluid line fluidically connects the reservoir tank to a receiving container. The liquid biological medium can be transferred from the reservoir tank through the fluid line into the at least one receiving container. The bioprocessing installation comprises a sensor arrangement with at least one gas bubble sensor, which sensor arrangement is configured to detect one or more gas bubbles or foam or separated phases in the liquid biological medium by a gas bubble sensor and to generate one or more corresponding sensor signals, and the electronic control unit is configured to monitor the transfer of the liquid biological medium from the reservoir tank in the direction of the at least one receiving container based on the sensor signals generated by the sensor arrangement.

Abstract: A method for the dynamic inline mixing of a pressurized medium containing a liquid and at least one further liquid or solid constituent in a bioprocess arrangement, the liquid being merged with the at least one further liquid or solid constituent in a predefined volume ratio at an opening point to form a resulting liquid flow, the bioprocess arrangement having a pump arrangement with a first pump, the first pump being arranged in the line of the line arrangement, the first pump being designed as a rotary pump configured for the dynamic inline mixing of the medium, the first pump having a liquid inlet, which during intended operation forms the suction side of the pump, and a liquid outlet, which during intended operation forms the pressure side of the pump, and the medium being conducted through the rotary pump for the purpose of dynamic inline mixing.

Abstract: Embodiments relate to a bioprocessing system having a main line for conduction of a main flow of a liquid medium, having a main flow pump and having a system part connected to the main line. The bioprocessing system comprises a powder transfer system and a feed line which is connected to the powder transfer system and which opens into the main line and which comprises a return flow preventer for prevention of a return flow of liquid medium, the powder transfer system feeds the additive into the feed line in powder form and drives it toward the feed point by means of a pressurized transport gas and at least some of the fed additive is input into the liquid medium within the main line downstream of the feed point before the liquid medium enriched with the additive passes through or reaches the system part connected to the main line.

Abstract: A device arrangement for separating cells from a culture medium in a bioprocess, in particular in a biopharmaceutical process, including a storage tank for the culture medium; a filtration module having a membrane adapted to be overflowed; an intake line connecting the storage tank to an unfiltrate inlet for supplying culture medium into the filtration module; a return line which connects a retentate-side outlet of the filtration module to the storage tank for returning retentate into the storage tank; a filtrate line which is connected to a permeate-side outlet of the filtration module for discharging filtrate; a first pump for maintaining a recirculation circuit; a backflush line which leads to a permeate-side connection and/or to the permeate-side outlet for supplying a rinsing liquid into the filtration module; and a second pump for conveying the rinsing liquid into the filtration module. A method of separating cells from a culture medium.

Abstract: Embodiments include a device for continuous virus inactivation during a protein production process comprising a first and a second fluid inlet, a first mixer, and a fluid outlet. A first liquid stream containing a target protein is introducible into the device through the first fluid inlet and is combinable in a predefined volume ratio with a second, virus-inactivating liquid stream introducible into the device through the second fluid inlet to form a third, reactive liquid stream which is conducted through the first mixer for mixing in order to generate predefined, virus-inactivating conditions. The device further comprises a head part and, downstream of the first mixer and upstream of the fluid outlet, a residence time arrangement fluidically connected to the head part for provision of a minimum residence time of the third stream, wherein the head part and the residence time arrangement are rigidly fastened to each other.

Abstract: The invention relates to an apparatus 10 for storing and/or processing at least one medium 11, in particular a bioprocessing device, comprising at least one disposable container 1, which is designed to accommodate at least some of the at least one medium 11, and at least one overpressure protection means 5, which is fluid-connected to the at least one disposable container 1. The at least one overpressure protection means is designed, when triggered, to conduct at least some of the at least one medium 11 into an apparatus region 3a? in front of the overpressure protection means 5 in relation to a flow direction F, in particular into the at least one disposable container 1 and/or into at least one further, second container 1a.

Abstract: A single-use filtration device including a plurality of single-use filter capsules connected with each other by rigid lines, of which at least a part is firmly mounted in a raster universally specified by a holder. The filter capsules, in particular as regards the type of filter, type of construction and/or size, and/or the connections of the filter capsules, are preconfigured for a desired filtration process.

Abstract: A method of filtering a large volume of a medium using a pre-sterilizable, at least partially automated single-use filtration device which includes an unfiltrate inlet, a filtrate outlet, a main line running between the unfiltrate inlet and the filtrate outlet, filter elements arranged in the main line, a venting line and sensors for detecting specific process parameters and regulating means for adjusting specific process parameters, wherein the sensors and regulating means are connected to an external monitoring and control system which is adapted for evaluating and processing sensor data and for piloting the regulating means based on one or more control algorithms, comprises the following process steps: a) filling the single-use filtration device with medium with low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements; e) filtering the medium by means of the filter elements; f)

Abstract: A bioprocessing installation comprising a reservoir tank, one or more fluid lines, one or more receiving containers and an electronic control unit. The fluid line fluidically connects the reservoir tank to a receiving container. The liquid biological medium can be transferred from the reservoir tank through the fluid line into the at least one receiving container. The bioprocessing installation comprises a sensor arrangement with at least one gas bubble sensor, which sensor arrangement is configured to detect one or more gas bubbles or foam or separated phases in the liquid biological medium by a gas bubble sensor and to generate one or more corresponding sensor signals, and the electronic control unit is configured to monitor the transfer of the liquid biological medium from the reservoir tank in the direction of the at least one receiving container based on the sensor signals generated by the sensor arrangement.

Abstract: An automated single-use filtration device, in particular for large-volume filtration processes, comprises an unfiltrate inlet, one or more filter elements, a filtrate outlet and sensors for detecting specific process parameters and regulating mechanisms for adjusting specific process parameters. The sensors and regulating mechanisms are connected to an external monitoring and control system, which is adapted for evaluating and processing sensor data and for piloting the regulating mechanisms based on one or more control algorithms.

Abstract: The invention relates to a bioprocessing system having a main line (2) for conduction of a main flow (3) of a liquid, in particular biological, medium (45), having a main flow pump (5) for generation of the main flow (3) and having a system part (46) connected to the main line (2).

Abstract: The invention relates to an apparatus 10 for storing and/or processing at least one medium 11, in particular a bioprocessing device, comprising at least one disposable container 1, which is designed to accommodate at least some of the at least one medium 11, and at least one overpressure protection means 5, which is fluid-connected to the at least one disposable container 1. The at least one overpressure protection means is designed, when triggered, to conduct at least some of the at least one medium 11 into an apparatus region 3a? in front of the overpressure protection means 5 in relation to a flow direction F, in particular into the at least one disposable container 1 and/or into at least one further, second container 1a.

Abstract: A method of filtering a large volume of a medium using a pre-sterilizable, at least partially automated single-use filtration device which includes an unfiltrate inlet, a filtrate outlet, a main line running between the unfiltrate inlet and the filtrate outlet, filter elements arranged in the main line, a venting line and sensors for detecting specific process parameters and regulating means for adjusting specific process parameters, wherein the sensors and regulating means are connected to an external monitoring and control system which is adapted for evaluating and processing sensor data and for piloting the regulating means based on one or more control algorithms, comprises the following process steps: a) filling the single-use filtration device with medium with low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements; e) filtering the medium by means of the filter elements; f)

Abstract: An automated single-use filtration device, in particular for large-volume filtration processes, comprises an unfiltrate inlet, one or more filter elements, a filtrate outlet and sensors for detecting specific process parameters and regulating mechanisms for adjusting specific process parameters. The sensors and regulating mechanisms are connected to an external monitoring and control system, which is adapted for evaluating and processing sensor data and for piloting the regulating mechanisms based on one or more control algorithms.

Abstract: A device (1) is provided for ventilation and integrity testing of a filter unit (2) that can be supplied with pressure. The filter unit (2) has a filter element (9) arranged in a housing (6) between an inlet (7) and an outlet (8). The housing (6) can be ventilated by an air filter (3) connected to the housing interior (12). A filter valve (4) is arranged upstream of the air filter (3) facing the housing interior (12) and connects the air filter (3) to the housing interior (12). The air filter (3) can be connected on its side facing away from the housing interior (12) to a test line (14) for supplying pressure. An inlet valve (5) is arranged upstream of the inlet (7) and connects an inlet line (10) to the housing interior (12).

Abstract: A single-use filtration device (10) comprises a plurality of single-use filter capsules (12) connected with each other by rigid lines, of which at least a part is firmly mounted in a raster universally specified by a holder (14). The filter capsules (12), in particular as regards the type of filter, type of construction and/or size, and/or the connections of the filter capsules (12), are preconfigured for a desired filtration process.

Abstract: A device (1) is provided for ventilation and integrity testing of a filter unit (2) that can be supplied with pressure. The filter unit (2) has a filter element (9) arranged in a housing (6) between an inlet (7) and an outlet (8). The housing (6) can be ventilated by an air filter (3) connected to the housing interior (12). A filter valve (4) is arranged upstream of the air filter (3) facing the housing interior (12) and connects the air filter (3) to the housing interior (12). The air filter (3) can be connected on its side facing away from the housing interior (12) to a test line (14) for supplying pressure. An inlet valve (5) is arranged upstream of the inlet (7) and connects an inlet line (10) to the housing interior (12).

Abstract: The invention relates to a system and a method for cell separation via a filter, with a powder bag which can be arranged in a recirculation circuit and is partly filled with a pulverulent filter aid and to which a cell solution containing the cells to be separated can be delivered from a bioreactor via a pump arranged in the recirculation circuit, the bioreactor, which has an agitator, being arranged in the recirculation circuit, and, when the recirculation circuit is interrupted, the bioreactor being connectable to the filter.

Abstract: The invention relates to a system and a method for cell separation via a filter, with a powder bag which can be arranged in a recirculation circuit and is partly filled with a pulverulent filter aid and to which a cell solution containing the cells to be separated can be delivered from a bioreactor via a pump arranged in the recirculation circuit, the bioreactor, which has an agitator, being arranged in the recirculation circuit, and, when the recirculation circuit is interrupted, the bioreactor being connectable to the filter.

Abstract: The invention relates to a valve device and to a method for transferring a transfer medium, said valve device and method having an inflow, an outflow and two valve disks which are arranged one behind another in the direction of flow and are pivotable about a common rotational axis for opening and closing the lumen which surrounds them, wherein the inflow and the outflow are formed by two housing sections which are lockable together, the ends of which facing one another receive in each case a valve disk with a fixedly connected half-shaft, wherein, with the housing sections in the locked state, the two half-shafts form one common shaft which is pivotable about the rotational axis and the valve disks abut closely against one another, and wherein, with the housing sections in the non-locked state, the valve disks in each case close the lumen of the housing section receiving them.