Patents by Inventor Bernhard H. Geierstanger

Bernhard H. Geierstanger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING FGF21-ASSOCIATED DISORDERS
    Publication number: 20160051628
    Abstract: The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.
    Type: Application
    Filed: April 2, 2015
    Publication date: February 25, 2016
    Applicants: IRM LLC, NOVARTIS AG
    Inventors: Brian R. BOETTCHER, Andreas LOEW, Shari L. CAPLAN, Douglas S. DANIELS, Bernhard H. GEIERSTANGER, Norio HAMAMATSU, Stuart LICHT, Stephen Craig WELDON
  • Fibroblast growth factor 21 mutations
    Patent number: 9023791
    Abstract: The present invention provides novel polypeptide and protein variants of fibroblast growth factor 21 (FGF21) and pharmaceutical compositions comprising FGF21 polypeptide and protein variants.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: May 5, 2015
    Assignees: Novartis AG, IRM LLC
    Inventors: Brian R. Boettcher, Shari L. Caplan, Douglas S. Daniels, Bernhard H. Geierstanger, Norio Hamamatsu, Stuart Licht, Andreas Loew, Stephen Craig Weldon
  • METHODS OF TREATING FGF21-ASSOCIATED DISORDERS
    Publication number: 20120129766
    Abstract: The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.
    Type: Application
    Filed: November 15, 2011
    Publication date: May 24, 2012
    Applicants: IRM LLC, NOVARTIS AG
    Inventors: Brian R. BOETTCHER, Shari L. CAPLAN, Douglas S. DANIELS, Bernhard H. GEIERSTANGER, Norio HAMAMATSU, Stuart LICHT, Andreas LOEW, Stephen Craig WELDON
  • Site-specific labeling of proteins for NMR studies
    Publication number: 20090081690
    Abstract: Methods of producing and/or analyzing spectroscopically labeled proteins, e.g., proteins site-specifically labeled with NMR active isotopes, spin-labels, chelators for paramagnetic metals, and the like, are provided. The labeled proteins are produced in translation systems including orthogonal aminoacyl tRNA synthetase/tRNA pairs. Methods for assigning NMR resonances, e.g., methods using isotopically labeled proteins, are also provided.
    Type: Application
    Filed: November 17, 2008
    Publication date: March 26, 2009
    Inventors: Alexander Deiters, Bernhard H. Geierstanger, Peter G. Schultz
  • Site-Specific Labeling of Proteins for Nmr Studies
    Publication number: 20080171317
    Abstract: Methods of producing and/or analyzing spectroscopically labeled proteins, e.g., proteins site-specifically labeled with NMR active isotopes, spin-labels, chelators for paramagnetic metals, and the like, are provided. The labeled proteins are produced in translation systems including orthogonal aminoacyl tRNA synthetase/tRNA pairs. Methods for assigning NMR resonances, e.g., methods using isotopically labeled proteins, are also provided.
    Type: Application
    Filed: September 21, 2005
    Publication date: July 17, 2008
    Applicants: THE SCRIPPS RESEARCH INSTITUTE, IRM, LLC
    Inventors: Alexander Deiters, Bernhard H. Geierstanger, Peter G. Schultz
  • Apparatus and methods to process substrate surface features
    Publication number: 20040141887
    Abstract: The present invention provides apparatus for fluidly separating substrate surface features. The apparatus include arrays of apertures that correspond to at least a portion of an array of wells disposed in a micro-well plate and/or are structured to fluidly separate multiple surface features disposed on multiple substrates from one another. Related systems, kits, and methods are additionally provided.
    Type: Application
    Filed: November 7, 2003
    Publication date: July 22, 2004
    Applicant: IRM, LLC
    Inventors: James Kevin Mainquist, Bernhard H. Geierstanger, David C. Tully