Patents by Inventor Bernhard Hauer

Bernhard Hauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11021721
    Abstract: Presented herein are genetically engineered Pseudomonas strains capable of metabolizing ethylene glycol and producing polyhydroxyalkanoates.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: June 1, 2021
    Assignees: Alliance for Sustainable Energy, LLC, University of Stuttgart, UT-Battelle, LLC
    Inventors: Gregg Tyler Beckham, Mary Ann Franden, Lahiru N. Jayakody, Nick Johannes Petrus Wierckx, Janosch Alexander Klebensberger, Lars Mathias Blank, Wing-Jin Li, Bernhard Hauer, Nicholas S. Cleveland, William E. Michener, Jason Michael Whitham
  • Patent number: 10717973
    Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: July 21, 2020
    Assignee: BASF SE
    Inventors: Michael Breuer, Bernhard Hauer, Dieter Jendrossek, Gabriele Siedenburg, Juergen Pleiss, Demet Sirim, Silvia Fadenrecht
  • Publication number: 20190201721
    Abstract: Provided herein are oral care compositions comprising HABP, which are useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
    Type: Application
    Filed: October 25, 2016
    Publication date: July 4, 2019
    Inventors: Nina Schneider, Thomas Subkowski, Stefan Jenewein, Marvin Karos, Claus Bollschweiler, Volker Wendel, Thorsten Henkes, Sandra Facey, Bernhard Hauer
  • Publication number: 20190119665
    Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 25, 2019
    Inventors: Michael BREUER, Bernhard HAUER, Dieter JENDROSSEK, Gabriele SIEDENBURG, Juergen PLEISS, Demet SIRIM, Silvia FADENRECHT
  • Patent number: 10190112
    Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: January 29, 2019
    Assignee: BASF SE
    Inventors: Michael Breuer, Bernhard Hauer, Dieter Jendrossek, Gabriele Siedenburg, Juergen Pleiss, Demet Sirim, Silvia Fadenrecht
  • Publication number: 20190024126
    Abstract: Presented herein are genetically engineered Pseudomonas strains capable of metabolizing ethylene glycol and producing polyhydroxyalkanoates.
    Type: Application
    Filed: July 20, 2018
    Publication date: January 24, 2019
    Inventors: Gregg Tyler BECKHAM, Mary Ann FRANDEN, Lahiru N. JAYAKODY, Nick Johannes Petrus WIERCKX, Janosch Alexander KLEBENSBERGER, Lars Mathias BLANK, Wing-Jin LI, Bernhard HAUER, Nicholas S. CLEVELAND, William E. MICHENER
  • Publication number: 20180303740
    Abstract: Provided herein are oral care compositions comprising Hydrophobin-like proteins (HLPs), which are useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
    Type: Application
    Filed: October 25, 2016
    Publication date: October 25, 2018
    Inventors: Nina Schneider, Thomas Subkowski, Stefan Jenewein, Marvin Karos, Claus Bollschweiler, Volker Wendel, Jianhong Qiu, LaTonya Kilpatrick-Liverman, Lynette Zaidel, Melanie Melcher, Thorsten Henkes, Sandra Facey, Bernhard Hauer
  • Patent number: 9587257
    Abstract: The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to the method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: March 7, 2017
    Assignee: BASF SE
    Inventors: Bernhard Hauer, Hans Wolfgang Höffken, Cecilia Kvarnström Branneby, Helmut Schwab, Sabine Feichtenhofer, Marlene Buchebner, Brigitte Pohn
  • Publication number: 20160340666
    Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
    Type: Application
    Filed: August 11, 2016
    Publication date: November 24, 2016
    Inventors: Michael Breuer, Bernhard Hauer, Dieter Jendrossek, Gabrielle Siedenburg, Juergen Pleiss, Demet Sirim, Silivia Fadenrecht
  • Patent number: 9447404
    Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: September 20, 2016
    Assignee: BASF SE
    Inventors: Michael Breuer, Bernhard Hauer, Dieter Jendrossek, Gabrielle Siedenburg, Juergen Pleiss, Demet Sirim, Silvia Fadenrecht
  • Publication number: 20160201093
    Abstract: A process for preparing linear or branched primary alcohols with 3 to 13 carbon atoms from linear or branched alkanes with 3 to 13 carbon atoms by incubating a host organism having a functional P153 enzyme under elevated pressure in the presence of oxygen.
    Type: Application
    Filed: July 21, 2014
    Publication date: July 14, 2016
    Applicant: BASF SE
    Inventors: Michael Breuer, Boris Breitscheidel, Hans-Günter Wagner, Detlef Kratz, Bernhard Hauer, Daniel Scheps, Bernd Nebel
  • Publication number: 20160168597
    Abstract: A process for preparing 1-butanol from butane by incubating a host organism having a functional P153 enzyme under elevated butane pressure in the presence of oxygen.
    Type: Application
    Filed: July 21, 2014
    Publication date: June 16, 2016
    Applicant: BASF SE
    Inventors: Michael Breuer, Boris Breitscheidel, Hans-Günter Wagner, Detlef Kratz, Bernhard Hauer, Daniel Scheps, Bernd Nebel
  • Publication number: 20160168602
    Abstract: The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to the method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.
    Type: Application
    Filed: February 2, 2016
    Publication date: June 16, 2016
    Inventors: Bernhard Hauer, Hans Wolfgang Höffken, Cecilia Kvarnström Branneby, Helmut Schwab, Sabine Feichtenhofer, Marlene Buchebner, Brigitte Pohn
  • Patent number: 9187737
    Abstract: The invention relates to novel proteins having esterase activity, to mutants thereof, to nucleic acid sequences coding therefor, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: November 17, 2015
    Assignee: BASF SE
    Inventors: Michael Breuer, Bernhard Hauer, Ulrich Schwaneberg, Tuck Seng Wong
  • Patent number: 9096841
    Abstract: The present invention relates to a process for the biocatalytic, enantioselective production of a ?-amino acid precursor from an optionally substituted dihydrouracil using a hydantoinase and/or a dihydropyrimidinase, a process for producing a ?-amino acid from said precursor, a hydantoinase and its use in said process for the biocatalytic production of a ?-amino acid precursor or a ?-amino acid, and a method for obtaining said hydantoinase.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: August 4, 2015
    Assignee: BASF SE
    Inventors: Nina Schneider, Bernhard Hauer, Klaus Ditrich, Maeve O'Neil, Nick Turner
  • Patent number: 9085786
    Abstract: The present invention relates to a process for the production of a polyamine involving the use of enzymes; in particular to a process performed in aqueous environment; to the polyamines produced by said method; as well as the use of said polyamines for manufacturing paper, for immobilizing enzymes, or for preparing pharmaceutical or cosmetical compositions. The invention also relates to a novel method for in situ regeneration of cofactors NAD(P)+.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: July 21, 2015
    Assignee: BASF SE
    Inventors: Bernhard Hauer, David Karim Engelmark Cassimjee, Per Berglund
  • Publication number: 20150147800
    Abstract: The present invention relates to a method for the enzymatic decarboxylation of malonic acid (propanedioic acid) derivatives catalyzed by enzymes structurally and/or functionally related to arylmalonate decarboxylase (AMDase) as isolated from microorganisms of the genus Bordetella. The present invention also relates to novel enzymes with a decarboxylase activity, useful for performing the claimed method, mutants thereof, corresponding coding sequences and expression systems, methods of preparing said novel enzymes, and screening methods for obtaining further suitable enzymes also having said decarboxylase activity.
    Type: Application
    Filed: December 29, 2014
    Publication date: May 28, 2015
    Inventors: Bernhard Hauer, Nina Schneider, Krzysztof Okrasa, Jason Micklefield, David Leys, Colin Levy
  • Publication number: 20150104851
    Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
    Type: Application
    Filed: December 4, 2014
    Publication date: April 16, 2015
    Inventors: Michael Breuer, Bernhard Hauer, Dieter Jendrossek, Gabrielle Siedenburg, Juergen Pleiss, Demet Sirim, Silvia Racolta
  • Patent number: 8951750
    Abstract: The present invention relates to a method for the enzymatic decarboxylation of malonic acid (propanedioic acid) derivatives catalyzed by enzymes structurally and/or functionally related to arylmalonate decarboxylase (AMDase) as isolated from microorganisms of the genus Bordetella. The present invention also relates to novel enzymes with a decarboxylase activity, useful for performing the claimed method, mutants thereof, corresponding coding sequences and expression systems, methods of preparing said novel enzymes, and screening methods for obtaining further suitable enzymes also having said decarboxylase activity.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: February 10, 2015
    Assignee: BASF SE
    Inventors: Bernhard Hauer, Nina Schneider, Krzysztof Okrasa, Jason Micklefield, David Leys, Colin Levy
  • Patent number: 8932837
    Abstract: Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which R1 stands for alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or hetaryl, and R2 stands for alkyl, cycloalkyl or aryl, in which an enantiomeric mixture of a simply N-acylated 3-aminocarboxylic acid ester of general formula (I.b), in which R1 and R2 have the meanings given above and R3 stands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim 1.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: January 13, 2015
    Assignee: BASF SE
    Inventors: Bernhard Hauer, Thomas Friedrich, Rainer Stürmer, Nina Schneider, Susanne Sabrowski, Wolf-Rüdiger Krahnert