Abstract: The present invention relates to a method for producing a transgenic non human male animal, preferably a mammal, fish, bird or insect, wherein the transgene(s) confer(s) a change in the transmission ratio of (a) genetic trait(s) to the offspring of said non human male animal, preferably mammal, fish, bird or insect to a non-Mendelian ratio, said method comprising introducing (a) a first nucleic acid molecule encoding an expression product with a Responder function into a chromosome of a non-human germ cell, (fertilized) egg cell, embryonic cell or a cell derived therefrom, of the same species as the transgenic male to be prepared, said chromosome containing or conferring said genetic trait(s), thereby linking on said chromosome said Responder function to the genetic trait(s); and (b) at least one second nucleic acid molecule encoding an expression product with a Distorter function into (a) chromosome(s) of a non-human germ cell, (fertilized) egg cell, embryonic cell or a cell derived therefrom, of the same sp

Abstract: The present invention relates to nucleic acid molecules encoding expression products involved in the Responder function, which contributes to the phenomenon of transmission ratio distortion. The present invention also relates to regulatory regions of the genes corresponding to said nucleic acid molecules. The present invention further relates to recombinant DNA molecules and vectors comprising said nucleic acid molecules and/or regulatory regions as well as to host cells transformed therewith. Additionally, the present invention relates to transgenic animals, comprising said nucleic acid molecules, recombinant DNA molecules or vectors stably integrated into their genome. The various embodiments of the invention have a significant impact on breeding strategies by allowing for the specific selection of genetic traits and in particular of sex. Further, the present invention finds applications in the development of contraceptiva.

Abstract: The present invention relates to nucleic acid molecules encoding expression products involved in the Responder function, which contributes to the phenomenon of transmission ratio distortion. The present invention also relates to regulatory regions of the genes corresponding to the nucleic acid molecules. The present invention further relates to recombinant DNA molecules and vectors comprising the nucleic acid molecules and/or regulatory regions as well as to host cells transformed therewith. Additionally, the present invention relates to transgenic animals, comprising the nucleic acid molecules, recombinant DNA molecules or vectors stably integrated into their genome. The various embodiments of the invention have a significant impact on breeding strategies by allowing for the specific selection of genetic traits and in particular of sex. Further, the present invention finds applications in the development of contraceptive.

Abstract: A targeting device for x-ray locating during an extracorporeal treatment of patients with focused shock waves, particularly for a lithotritor, is suggested. The targeting device comprises a carrier on or in which x-ray positive elements, preferably metal wires, are arranged such that they point to the focal point of the shock wave system. In the x-ray image, the position of the elements clearly indicates the position of the focal point.

Abstract: A lithotripter includes a therapeutic head provided with a source for focusing shockwaves in a focal point on a first axis; an ultrasonic transducer having an axis for imaging an area in a patient in which shockwaves are to be focussed is connected to the therapeutic head for movement in relation to the head in isocentric relation to that focal point such that two axes intersect in that focal point, independently form a variable angular orientation of the axes to each other.

Abstract: A lithotripter has a source for focussed shockwaves and an X-ray device which is mounted for relative displacement and positioning in relation to that source of shockwaves; an improvement includes a device for aiming and sighting in cooperation with the X-ray equipment that includes a carrier element defining a first pair of X-ray contrasting aligned reference points and two additional X-ray contrasting reference points, on a second line and intersecting the first line at a point of intersection at about 15 to 45 degrees; and that aiming and sighting device is mounted in relation to said source of focussed shockwaves such that the point of intersection coincide with a focal point of the shockwave source.