Patents by Inventor Bernhard Mullinger
Bernhard Mullinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10561805Abstract: Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of hRSV and that neutralize RSV infection are administered to the lungs of young children at specific dose regimens.Type: GrantFiled: October 9, 2015Date of Patent: February 18, 2020Assignees: ABLYNX N.V., VECTURA GMBHInventors: Koen Allosery, Erik Depla, Martin Huber, Tobias Kolb, Bernhard Müllinger, Massimiliano Germani, Juliane Schick, Maria-Laura Sargentini
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Patent number: 10512739Abstract: An inhalation device, assembly or system can include a kit and a pharmaceutical composition. The device can be adapted for administering therapeutic aerosols to pediatric patients, including neonates, infants or toddlers. The device can further include a vibrating mesh aerosol generator that can be insertable into a flow channel of the inhalation device through a lateral opening, and a valved face mask. The device can be connectable to a gas source through which a gas, such as oxygen, can be received into the flow channel at a low flow rate.Type: GrantFiled: October 9, 2015Date of Patent: December 24, 2019Assignees: VECTURA GMBH, ABLYNX N.V.Inventors: Koen Allosery, Martin Huber, Tobias Kolb, Bernhard Müllinger, Juliane Schick, Erik Depla
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Publication number: 20170304565Abstract: An inhalation device, assembly or system can include a kit and a pharmaceutical composition. The device can be adapted for administering therapeutic aerosols to pediatric patients, including neonates, infants or toddlers. The device can further include a vibrating mesh aerosol generator that can be insertable into a flow channel of the inhalation device through a lateral opening, and a valved face mask. The device can be connectable to a gas source through which a gas, such as oxygen, can be received into the flow channel at a low flow rate.Type: ApplicationFiled: October 9, 2015Publication date: October 26, 2017Inventors: Koen ALLOSERY, Martin HUBER, Tobias KOLB, Bernhard MÜLLINGER, Juliane SCHICK, Erik DEPLA
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Publication number: 20170304566Abstract: Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of hRSV and that neutralize RSV infection are administered to the lungs of young children at specific dose regimens.Type: ApplicationFiled: October 9, 2015Publication date: October 26, 2017Inventors: Koen ALLOSERY, Erik DEPLA, Martin HUBER, Tobias KOLB, Bernhard MÜLLINGER, Massimiliano GERMANI, Juliane SCHICK, Maria-Laura SARGENTINI
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Publication number: 20150165137Abstract: An inhalation device having a base unit, a mouthpiece, and an aerosol head is provided. The base unit has an air inlet, an air outlet opening, a groove for receiving the mouthpiece, and key lock member(s). The mouthpiece has two segments: a first segment which is insertable into the groove of the base unit and has an air inlet opening and a lateral opening for receiving an aerosol generator and a second segment with an aerosol outlet. The aerosol head has an aerosol generator, a liquid reservoir, and key lock member(s) complementary to those of the base unit. The base unit, mouthpiece and aerosol head are connectable with one another such that when engaging the members of the key lock with the complementary members, the aerosol generator is inserted into the lateral opening of the mouthpiece.Type: ApplicationFiled: October 21, 2014Publication date: June 18, 2015Applicant: Vectura GmbHInventors: Bernhard Mullinger, Tobias Kolb, Martin Huber, Tobias Hoffmann
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Patent number: 8910625Abstract: An inhalation device having a base unit, a mouthpiece, and an aerosol head is provided. The base unit has an air inlet, an air outlet opening, a groove for receiving the mouthpiece, and key lock member(s). The mouthpiece has two segments: a first segment which is insertable into the groove of the base unit and has an air inlet opening and a lateral opening for receiving an aerosol generator and a second segment with an aerosol outlet. The aerosol head has an aerosol generator, a liquid reservoir, and key lock member(s) complementary to those of the base unit. The base unit, mouthpiece and aerosol head are connectible with one another such that when engaging the members of the key lock with the complementary members, the aerosol generator is inserted into the lateral opening of the mouthpiece.Type: GrantFiled: October 25, 2013Date of Patent: December 16, 2014Assignee: Vectura GmbHInventors: Bernhard Mullinger, Tobias Kolb, Martin Huber, Tobias Hoffmann
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Publication number: 20140116426Abstract: The invention provides an inhalation device comprising a base unit, a mouthpiece, and an aerosol head. The base unit comprises an air inlet, an air outlet opening, a groove for receiving the mouthpiece, and key lock member(s). The mouthpiece comprises a first segment, comprising an air inlet opening and a lateral opening for receiving an aerosol generator, the first segment being insertable into the groove of the base unit, and a second segment comprising an aerosol outlet. The aerosol head comprises an aerosol generator, a liquid reservoir, and key lock member(s) complementary to the key lock member(s) of the base unit. The base unit, mouthpiece and aerosol head are connectable with one another such that when engaging the members of the key lock with the complementary members, the aerosol generator is inserted into the lateral opening of the mouthpiece.Type: ApplicationFiled: October 25, 2013Publication date: May 1, 2014Applicant: ACTIVAERO GMBHInventors: Bernhard Mullinger, Tobias Kolb, Martin Huber
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Patent number: 8684002Abstract: A device for the flow rate limitation at low differential pressures, in particular for the limitation of the inhalation volume flow during the inhalation of therapeutic aerosols, comprising a housing with at least an inlet opening, at least an outlet opening and a flow channel arranged therebetween, wherein the flow channel is restricted by a flexible wall extending along the flow channel, characterized in that the flexible wall has a control area of less than 100 mm2.Type: GrantFiled: August 3, 2010Date of Patent: April 1, 2014Assignee: Activaero GmbHInventors: Martin Huber, Tobias Kolb, Bernhard Müllinger
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Patent number: 8534277Abstract: The present invention is directed to the administration of aerosolized particles to specific area of the lungs, and in particular to the targeted delivery of aerosolized pharmaceutical formulations to a specific area of the lungs. More specifically, the present invention relates to devices and methods for depositing aerosolized particles to a specific area of the lungs by regulating aerosolizing parameters of the device. The present invention also relates to devices, systems and methods for disease management, where the aerosolizing parameters are adjusted based on monitoring at least one health parameter.Type: GrantFiled: July 31, 2008Date of Patent: September 17, 2013Assignee: Activaero GmbHInventors: Alex Stenzler, William C. Zimlich, Gerhard Scheuch, Bernhard Müllinger, Tobias Kolb, Tobias Hoffmann, Andreas Wenker, Axel Fischer, Sascha Roeder
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Publication number: 20130034534Abstract: A method for treatment of patients with cystic fibrosis by providing an inhalable aerosol comprising a mucolytic compound (dornase alpha) administered into a patient's lungs according to a specific treatment protocol setting comprising a mucolytic drug containing aerosol having particles with a predetermined mass medial aerodynamic diameter (MMAD) delivered predominantly to a peripheral lungs using a nebulizing system able to administer said aerosol with overpressure and under controlled breathing conditions.Type: ApplicationFiled: September 29, 2010Publication date: February 7, 2013Inventors: Philipp Kroneberg, Bernhard Mullinger, Harm A.W.N. Tiddens, Marije van den Beukel-Bakker
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Patent number: 8181644Abstract: The present invention relates to a device for providing an aerosol flow, an air flow or both with at least a compressor for providing an air flow, a nebulization device for generating an aerosol flow and a mixing means for optionally mixing the aerosol flow with the air flow to provide a total flow, wherein the total flow is composed of the aerosol flow, the air flow or both. Further, the device comprises at least a first air channel between the compressor and the nebulization device, at least a second air channel between the compressor and the mixing means and an amplification means for increasing the air flow provided by the compressor.Type: GrantFiled: September 4, 2008Date of Patent: May 22, 2012Assignee: Activaero GmbHInventors: Bernhard Mullinger, Manuel Frey, Tobias Kolb, Tobias Hoffmann
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Publication number: 20110030682Abstract: The invention relates to a device for the flow rate limitation at low differential pressures, in particular for the limitation of the inhalation volume flow during the inhalation of therapeutic aerosols, comprising a housing with at least an inlet opening, at least an outlet opening and a flow channel arranged therebetween, wherein the flow channel is restricted by a flexible wall extending along the flow channel, characterised in that the flexible wall has a control area of less than 100 mm2.Type: ApplicationFiled: August 3, 2010Publication date: February 10, 2011Applicant: Activaero GmbHInventors: Martin Huber, Tobias Kolb, Bernhard Müllinger
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Patent number: 7766012Abstract: A device for the controlled inhalation of therapeutic aerosols comprises means providing individual patient parameters and/or aerosol parameters for the inhalation. The aerosol doses, such as the tidal volume and the respiratory flow, are individually adjusted on the basis of these individual parameters. Thus, the inhalation device may be individually adjusted to the patient to be treated.Type: GrantFiled: March 16, 2001Date of Patent: August 3, 2010Assignee: Activaero GmbHInventors: Gerhard Scheuch, Thomas Meyer, Knut Sommerer, Axel Greindl, Bernhard Müllinger
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Publication number: 20090178672Abstract: The present invention is directed to methods, systems and computer-readable products for optimizing aerosol particle administration to the lungs. More specifically, the present invention relates to methods of tailoring inhaling maneuvers for aerosol particle administration using the subject's lung function data and to systems and computer-readable products carrying out such methods.Type: ApplicationFiled: December 4, 2008Publication date: July 16, 2009Applicant: ACTIVAERO GMBHInventors: Bernhard Mullinger, Philipp Kroneberg, Marion Wencker
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Publication number: 20090064995Abstract: The present invention relates to a device for providing an aerosol flow, an air flow or both with at least a compressor for providing an air flow, a nebulization device for generating an aerosol flow and a mixing means for optionally mixing the aerosol flow with the air flow to provide a total flow, wherein the total flow is composed of the aerosol flow, the air flow or both. Further, the device comprises at least a first air channel between the compressor and the nebulization device, at least a second air channel between the compressor and the mixing means and an amplification means for increasing the air flow provided by the compressor.Type: ApplicationFiled: September 4, 2008Publication date: March 12, 2009Applicant: ACTIVAERO GMBHInventors: Bernhard Mullinger, Manuel Frey, Tobias Kolb, Tobias Hoffmann
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Publication number: 20090056708Abstract: The present invention is directed to the administration of aerosolized particles to specific area of the lungs, and in particular to the targeted delivery of aerosolized pharmaceutical formulations to a specific area of the lungs. More specifically, the present invention relates to devices and methods for depositing aerosolized particles to a specific area of the lungs by regulating aerosolizing parameters of the device. The present invention also relates to devices, systems and methods for disease management, where the aerosolizing parameters are adjusted based on monitoring at least one health parameter.Type: ApplicationFiled: July 31, 2008Publication date: March 5, 2009Applicants: ACTIVAERO GMBH, CARDINAL HEALTH 207, INC.Inventors: Alex Stenzler, William C. Zimlich, Gerhard Scheuch, Bernhard Mullinger, Tobias Kolb, Tobias Hoffmann, Andreas Wenker, Axel Fischer, Sascha Roeder
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Patent number: 6681762Abstract: A device for flow rate limitation at low differential pressures, particularly for limiting the volumetric inhalation flow during inhalation of therapeutic aerosols, consists of a housing 11 including an aspiration orifice 14, an inhalation orifice 15 and a flow passage 23 disposed therebetween. The flow passage has a flat elongate cross-section with flexible large-area walls 18, 20 having a cross-sectional area adapted to be reduced, as a function of the differential pressure prevailing between the inhalation orifice and the aspiration orifice, as well as of the flexibility of the material of the walls, to a size appropriate for a predetermined volumetric maximum inhalation flow.Type: GrantFiled: March 16, 2000Date of Patent: January 27, 2004Assignee: GSF-Forschungszentrum fur Umwelt und Gesundheit GmbHInventors: Gerhard Scheuch, Knut Sommerer, Bernhard Müllinger, Friedel Haas, Sascha Roeder
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Patent number: 6571791Abstract: An inhalation device has a container 2 for an aerosol volume inhaled via a channel 15 and a mouthpiece 14, the container being located within a housing 12. The aerosol, in particular vitamin A, is introduced from a cartridge 17 into the interior of the container 2 via a nebulizer 18. The breath flow in the inhalation device is controlled via a control means 5 that keeps the inhalation flow essentially constant during the entire inhalation period.Type: GrantFiled: June 12, 2001Date of Patent: June 3, 2003Assignee: InAMed GmbHInventors: Gerhard Scheuch, Knut Sommerer, Friedel Haas, Bernhard Müllinger, Sascha Roeder
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Patent number: 6544312Abstract: In a device for separating the particle size spectrum of a polydisperse aerosol comprising a housing including an inlet part, a guide part, an outlet part, a nozzle insert and a separation insert, all parts are axially symmetrical and joined by centering fits so that they are easy to manufacture and can easily be assembled and also replaced. The parts are so fitted together that they are automatically centered during assembly while providing for the properly sized aerosol and air supply and particle fraction extraction channels.Type: GrantFiled: September 17, 2001Date of Patent: April 8, 2003Assignee: GSF Forschungszentrum fur Umwelt und Gesundheit GmbHInventors: Bernhard Müllinger, Joachim Heyder
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Patent number: D742503Type: GrantFiled: December 23, 2013Date of Patent: November 3, 2015Assignee: Vectura GmbHInventors: Bernhard Müllinger, Tobias Kolb, Martin Huber, William C. Zimlich, II, Ian Mahaffy