Abstract: An inhalation device having a base unit, a mouthpiece, and an aerosol head is provided. The base unit has an air inlet, an air outlet opening, a groove for receiving the mouthpiece, and key lock member(s). The mouthpiece has two segments: a first segment which is insertable into the groove of the base unit and has an air inlet opening and a lateral opening for receiving an aerosol generator and a second segment with an aerosol outlet. The aerosol head has an aerosol generator, a liquid reservoir, and key lock member(s) complementary to those of the base unit. The base unit, mouthpiece and aerosol head are connectable with one another such that when engaging the members of the key lock with the complementary members, the aerosol generator is inserted into the lateral opening of the mouthpiece.

Abstract: An inhalation device having a base unit, a mouthpiece, and an aerosol head is provided. The base unit has an air inlet, an air outlet opening, a groove for receiving the mouthpiece, and key lock member(s). The mouthpiece has two segments: a first segment which is insertable into the groove of the base unit and has an air inlet opening and a lateral opening for receiving an aerosol generator and a second segment with an aerosol outlet. The aerosol head has an aerosol generator, a liquid reservoir, and key lock member(s) complementary to those of the base unit. The base unit, mouthpiece and aerosol head are connectible with one another such that when engaging the members of the key lock with the complementary members, the aerosol generator is inserted into the lateral opening of the mouthpiece.

Abstract: The invention provides an inhalation device comprising a base unit, a mouthpiece, and an aerosol head. The base unit comprises an air inlet, an air outlet opening, a groove for receiving the mouthpiece, and key lock member(s). The mouthpiece comprises a first segment, comprising an air inlet opening and a lateral opening for receiving an aerosol generator, the first segment being insertable into the groove of the base unit, and a second segment comprising an aerosol outlet. The aerosol head comprises an aerosol generator, a liquid reservoir, and key lock member(s) complementary to the key lock member(s) of the base unit. The base unit, mouthpiece and aerosol head are connectable with one another such that when engaging the members of the key lock with the complementary members, the aerosol generator is inserted into the lateral opening of the mouthpiece.

Abstract: A method for treatment of patients with cystic fibrosis by providing an inhalable aerosol comprising a mucolytic compound (dornase alpha) administered into a patient's lungs according to a specific treatment protocol setting comprising a mucolytic drug containing aerosol having particles with a predetermined mass medial aerodynamic diameter (MMAD) delivered predominantly to a peripheral lungs using a nebulizing system able to administer said aerosol with overpressure and under controlled breathing conditions.

Abstract: The present invention relates to a device for providing an aerosol flow, an air flow or both with at least a compressor for providing an air flow, a nebulization device for generating an aerosol flow and a mixing means for optionally mixing the aerosol flow with the air flow to provide a total flow, wherein the total flow is composed of the aerosol flow, the air flow or both. Further, the device comprises at least a first air channel between the compressor and the nebulization device, at least a second air channel between the compressor and the mixing means and an amplification means for increasing the air flow provided by the compressor.

Abstract: The present invention is directed to methods, systems and computer-readable products for optimizing aerosol particle administration to the lungs. More specifically, the present invention relates to methods of tailoring inhaling maneuvers for aerosol particle administration using the subject's lung function data and to systems and computer-readable products carrying out such methods.

Abstract: The present invention relates to a device for providing an aerosol flow, an air flow or both with at least a compressor for providing an air flow, a nebulization device for generating an aerosol flow and a mixing means for optionally mixing the aerosol flow with the air flow to provide a total flow, wherein the total flow is composed of the aerosol flow, the air flow or both. Further, the device comprises at least a first air channel between the compressor and the nebulization device, at least a second air channel between the compressor and the mixing means and an amplification means for increasing the air flow provided by the compressor.

Abstract: The present invention is directed to the administration of aerosolized particles to specific area of the lungs, and in particular to the targeted delivery of aerosolized pharmaceutical formulations to a specific area of the lungs. More specifically, the present invention relates to devices and methods for depositing aerosolized particles to a specific area of the lungs by regulating aerosolizing parameters of the device. The present invention also relates to devices, systems and methods for disease management, where the aerosolizing parameters are adjusted based on monitoring at least one health parameter.

Abstract: An inhalation device has a container 2 for an aerosol volume inhaled via a channel 15 and a mouthpiece 14, the container being located within a housing 12. The aerosol, in particular vitamin A, is introduced from a cartridge 17 into the interior of the container 2 via a nebulizer 18. The breath flow in the inhalation device is controlled via a control means 5 that keeps the inhalation flow essentially constant during the entire inhalation period.

Abstract: In a device for separating the particle size spectrum of a polydisperse aerosol comprising a housing including an inlet part, a guide part, an outlet part, a nozzle insert and a separation insert, all parts are axially symmetrical and joined by centering fits so that they are easy to manufacture and can easily be assembled and also replaced. The parts are so fitted together that they are automatically centered during assembly while providing for the properly sized aerosol and air supply and particle fraction extraction channels.