Patents by Inventor Bernhard Riefling

Bernhard Riefling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclopentane derivatives, methods for producing them and their use
    Patent number: 4885372
    Abstract: New cyclopentane derivatives of the formula I ##STR1## in which R.sup.1 is H or a hydroxyl protective group, andR.sup.2 and R.sup.3 are together an O atom or are together a bond, can be used in the preparation of prostaglandin derivatives.
    Type: Grant
    Filed: September 19, 1986
    Date of Patent: December 5, 1989
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Bernhard Riefling, Hans Witzel
  • Ketolactones
    Patent number: 4788299
    Abstract: New ketolactones of the formula I ##STR1## wherein R.sup.1 is H, alkyl having 1-6 C atoms or aryl having 6-14 C atoms andR.sup.2 and R.sup.3 together are an O atom or together are a bond,and salts thereof,can be used as intermediate products in the preparation of prostaglandin derivatives.
    Type: Grant
    Filed: June 17, 1987
    Date of Patent: November 29, 1988
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventor: Bernhard Riefling
  • New intermediates for the preparation of 13-thiaprostaglandin derivatives
    Patent number: 4733011
    Abstract: Compounds of the formula ##STR1## wherein A is C--C single bond, --CH.sub.2 --, --CH(CH.sub.3)--, --C(CH.sub.3).sub.2 --, --CH.sub.2 --CH.sub.2 --, CH(CH.sub.3)CH.sub.2 --, --C(CH.sub.3).sub.2 CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 -- or --CH.sub.2 O--; R.sup.1a and R.sup.1 each independently is hydrogen or a protective group which can be cleaved by solvolysis or by hydrogenolysis; R.sup.2 is H or alkyl of 1 to 3 C atoms; R.sup.3 is alkyl of 3 to 5 C atoms, phenyl or phenyl which is monosubstituted to trisubstituted by F, Cl, OH, OCH.sub.3, OC.sub.2 H.sub.5, CF.sub.3 or alkyl of 1 to 3 C atoms, or, when A is not --CH.sub.2 O--, can also be pyridyl, thienyl, naphthyl or alkoxy of 1 to 4 C atoms; indicates a bond in the .beta.-position and wavy line ( ) means that the bond can be in the .alpha.- or .beta.-position, are valuable intermediates for the stereospecific preparation of 13-thiaprostaglandin derivatives. The latter are prepared by U.V.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: March 22, 1988
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Bernhard Riefling, Hans-Eckart Radunz
  • Sulfur-containing 6-ketoprostaglandins
    Patent number: 4680288
    Abstract: Sulfur-containing 6-ketoprostaglandins of the formula I ##STR1## in which D is a bond, alkylene having 1-3 C atoms, cis-alkenylene having 2-5 C atoms or alkinylene having 2-5 C atoms,R.sup.1 is H, alkyl having 1-4 C atoms, aryl having 6-12 C atoms or --C.sub.6 H.sub.4 NHCOC.sub.6 H.sub.5,R.sup.2 is alkyl having 1-7 C atoms, alkyl having 1-7 C atoms which is substituted by halogen, cycloalkyl having 5-6 C atoms, cycloalkyl having 5-6 C atoms which is substituted by alkyl having 1-4 C atoms, phenyl, phenyl which is substituted by F, Cl, Br, alkyl having 1-4 C atoms, OH, OCH.sub.3 or CF.sub.3, pyridyl, naphthyl, thienyl or, if D is alkylene having 1-3 C atoms, also is alkoxy having 1-4 C atoms, alkylthio having 1-4 C atoms, phenoxy or phenoxy which is substituted by F, Cl, Br, alkyl having 1-4 C atoms, OH, OCH.sub.3 or CF.sub.3,R.sup.3 and R.sup.
    Type: Grant
    Filed: January 18, 1985
    Date of Patent: July 14, 1987
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Klaus Irmscher, Hans-Eckart Radunz, Ernst Schulze, Bernhard Riefling