Patents by Inventor Bernhard Rudolf Gentner

Bernhard Rudolf Gentner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for improving retroviral transduction and gene editing in hematopoietic stem cells using cyclosporine h (CsH)
    Patent number: 11964027
    Abstract: Use of cyclosporin H (CsH) or a derivative thereof for increasing the efficiency of transduction of an isolated population of cells by a viral vector and/or increasing the efficiency of gene editing of an isolated population of cells when transduced by a viral vector.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: April 23, 2024
    Inventors: Anna Christina Kajaste-Rudnitski, Carolina Petrillo, Bernhard Rudolf Gentner, Luigi Naldini, Pietro Genovese, Giulia Schiroli
  • GENE VECTOR
    Publication number: 20220333103
    Abstract: A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 20, 2022
    Inventors: Alessandra Biffi, Bernhard Rudolf Gentner, Luigi Naldini
  • Gene vector
    Patent number: 11407996
    Abstract: A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: August 9, 2022
    Assignees: Ospedale San Raffaele S.r.l., Fondazione Telethon
    Inventors: Alessandra Biffi, Bernhard Rudolf Gentner, Luigi Naldini
  • GENE THERAPY
    Publication number: 20210121579
    Abstract: Use of cyclosporin H (CsH) or a derivative thereof for increasing the efficiency of transduction of an isolated population of cells by a viral vector and/or increasing the efficiency of gene editing of an isolated population of cells when transduced by a viral vector.
    Type: Application
    Filed: April 20, 2018
    Publication date: April 29, 2021
    Inventors: Anna Christina KAJASTE-RUDNITSKI, Carolina PETRILLO, Bernhard Rudolf GENTNER, Luigi NALDINI, Pietro GENOVESE, Giulia SCHIROLI
  • Method
    Publication number: 20200338131
    Abstract: A method of preparing a therapeutic cell population for clinical use from a starting population of cells comprising haematopoietic stem cells, said method comprising separating a population of cells that substantially do not express CD38 but which express CD34 from the starting population of cells, and transducing the separated cell population with a vector to obtain the therapeutic cell population.
    Type: Application
    Filed: March 24, 2020
    Publication date: October 29, 2020
    Inventors: Luigi Naldini, Bernhard Rudolf Gentner, Erika Zonari, Francesco Boccalatte
  • Methods for genetic modification of stem cells
    Patent number: 10617721
    Abstract: A method of preparing a therapeutic cell population for clinical use from a starting population of cells comprising haematopoietic stem cells, said method comprising separating a population of cells that substantially do not express CD38 but which express CD34 from the starting population of cells, and transducing the separated cell population with a vector to obtain the therapeutic cell population.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: April 14, 2020
    Assignees: OSPEDALE SAN RAFFAELE S.R.L., FONDAZIONE TELETHON
    Inventors: Luigi Naldini, Bernhard Rudolf Gentner, Erika Zonari, Francesco Boccalatte
  • GENE THERAPY
    Publication number: 20200078408
    Abstract: A hematopoietic stem cell (HSC), a hematopoietic progenitor cell (HPC) a myeloid/monocyte-committed progenitor cell, a macrophage or a monocyte comprising a vector wherein the vector comprises at least one mir-130a and/or mir-126 target sequence operably linked to a nucleotide sequence encoding interferon-alpha (IFN?) for use in treating or preventing a cancer in a patient, wherein the HSC, the HPC, the myeloid/monocyte-committed progenitor cell, the macrophage or the monocyte is used in combination with an immune checkpoint inhibitor and/or a tumor associated antigen (TAA)-specific T-cell.
    Type: Application
    Filed: April 20, 2018
    Publication date: March 12, 2020
    Inventors: Luigi Naldini, Giulia Escobar, Bernhard Rudolf Gentner, Adele Mucci
  • GENE VECTOR
    Publication number: 20190367911
    Abstract: A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell.
    Type: Application
    Filed: April 15, 2019
    Publication date: December 5, 2019
    Inventors: Alessandra Biffi, Bernhard Rudolf Gentner, Luigi Naldini
  • Gene vector
    Patent number: 10287579
    Abstract: A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: May 14, 2019
    Assignees: Ospedale San Raffaele S.r.l., Fondazione Telethon
    Inventors: Alessandra Biffi, Bernhard Rudolf Gentner, Luigi Naldini
  • Gene vector
    Patent number: 9951328
    Abstract: A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: April 24, 2018
    Assignees: Fondazione Telethon, Ospedale San Raffaele S.r.l.
    Inventors: Alessandra Biffi, Bernhard Rudolf Gentner, Luigi Naldini
  • GENE VECTOR
    Publication number: 20180044670
    Abstract: A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell.
    Type: Application
    Filed: August 31, 2017
    Publication date: February 15, 2018
    Applicant: Ospedale San Raffaele S.R.L.
    Inventors: Alessandra Biffi, Bernhard Rudolf Gentner, Luigi Naldini
  • Method
    Publication number: 20160256492
    Abstract: A method of preparing a therapeutic cell population for clinical use from a starting population of cells comprising haematopoietic stem cells, said method comprising separating a population of cells that substantially do not express CD38 but which express CD34 from the starting population of cells, and transducing the separated cell population with a vector to obtain the therapeutic cell population.
    Type: Application
    Filed: October 24, 2014
    Publication date: September 8, 2016
    Inventors: Luigi Naldini, Bernhard Rudolf Gentner, Erika Zonari, Francesco Boccalatte
  • GENE VECTOR
    Publication number: 20120128643
    Abstract: A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell.
    Type: Application
    Filed: April 30, 2010
    Publication date: May 24, 2012
    Applicants: FONDAZIONE TELETHON, FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
    Inventors: Alessandra Biffi, Bernhard Rudolf Gentner, Luigi Naldini