Patents by Inventor Bernhard Schaffar
Bernhard Schaffar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10156544Abstract: Methods and systems for hydrating and calibrating an electrochemical sensor are disclosed.Type: GrantFiled: November 3, 2015Date of Patent: December 18, 2018Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Bernhard Schaffar, Robert Poettler, Albert Romann
-
Publication number: 20160139075Abstract: Methods and systems for hydrating and calibrating an electrochemical sensor are disclosed.Type: ApplicationFiled: November 3, 2015Publication date: May 19, 2016Inventors: Bernhard Schaffar, Robert Poettler, Albert Romann
-
Patent number: 8652795Abstract: The present disclosure relates to a mutant lactate oxidase having increased stability, a nucleic acid encoding the mutant lactate oxidase, an expression vector comprising the nucleic acid, a host cell comprising the nucleic acid or the expression vector, a method of determining lactate in a sample, the use of the mutant lactate oxidase for determining lactate, a device for determining lactate in a sample using the mutant lactate oxidase and a kit for determining lactate comprising the mutant lactate oxidase.Type: GrantFiled: September 18, 2012Date of Patent: February 18, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Stefan Leitgeb, Thomas Meier, Bernd Nidetzky, Bernhard Schaffar, Thomas Stoisser
-
Publication number: 20130071868Abstract: The present disclosure relates to a mutant lactate oxidase having increased stability, a nucleic acid encoding the mutant lactate oxidase, an expression vector comprising the nucleic acid, a host cell comprising the nucleic acid or the expression vector, a method of determining lactate in a sample, the use of the mutant lactate oxidase for determining lactate, a device for determining lactate in a sample using the mutant lactate oxidase and a kit for determining lactate comprising the mutant lactate oxidase.Type: ApplicationFiled: September 18, 2012Publication date: March 21, 2013Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Stefan Leitgeb, Thomas Meier, Bernd Nidetzky, Bernhard Schaffar, Thomas Stoisser
-
Patent number: 8262992Abstract: The invention concerns a sensor cassette that can be inserted into an analyzer comprising a continuous measuring channel for receiving fluidic media and sensory elements for determining chemical and/or physical parameters of the fluidic media. According to the invention the sensor cassette consists of at least two permanently connected but separately manufactured modules which each have a housing and a measuring channel section wherein the measuring channel sections of adjacent modules are connected to the continuous measuring channel by a fluidic coupling and wherein at least one of the connected modules is designed as a sensor module and has a sensor array comprising at least two sensory elements. Furthermore, a memory element is allocated to the sensor cassette on which specific information for the sensor cassette in particular with regard to its construction from the respective modules is stored.Type: GrantFiled: November 12, 2008Date of Patent: September 11, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Heinz Kontschieder, Marco Jean Pierre Leiner, Wolfgang Huber, Franz-Josef Krysl, Christoph Ritter, Helmut Offenbacher, Bernhard Schaffar, Marie-Luise Schinnerl, Johann Harer
-
Patent number: 7815788Abstract: In a method for calibrating a biosensor for the amperometric determination of creatinine in biological liquids, consisting of one electrode system each for measuring the concentrations of creatinine and creatine, with at least two calibration solutions being used, the electrode system for measuring the creatinine concentration is calibrated with a creatinine solution which, prior to the calibration measurement, was mixed in the form of an acidic solution with an alkaline buffer solution, and the electrode system for measuring the creatine concentration is calibrated with a solution in which creatinine and creatine are at a thermodynamic equilibrium.Type: GrantFiled: March 28, 2008Date of Patent: October 19, 2010Assignee: Roche Diagnostics Operations, Inc.Inventors: Bernhard Schaffar, Herbert Kroneis, Taghi Noormofidi, Gernot Florian, Wolf-Dietrich Steinbock
-
Publication number: 20090156966Abstract: The invention concerns a sensor cassette that can be inserted into an analyzer comprising a continuous measuring channel for receiving fluidic media and sensory elements for determining chemical and/or physical parameters of the fluidic media. According to the invention the sensor cassette consists of at least two permanently connected but separately manufactured modules which each have a housing and a measuring channel section wherein the measuring channel sections of adjacent modules are connected to the continuous measuring channel by a fluidic coupling and wherein at least one of the connected modules is designed as a sensor module and has a sensor array comprising at least two sensory elements. Furthermore, a memory element is allocated to the sensor cassette on which specific information for the sensor cassette in particular with regard to its construction from the respective modules is stored.Type: ApplicationFiled: November 12, 2008Publication date: June 18, 2009Inventors: Heinz Kontschieder, Marco Jean Pierre Leiner, Wolfgang Huber, Franz-Josef Krysl, Christoph Ritter, Helmut Offenbacher, Bernhard Schaffar, Marie-Luise Schinnerl, Johann Harer
-
Publication number: 20080173064Abstract: In a method for calibrating a biosensor for the amperometric determination of creatinine in biological liquids, consisting of one electrode system each for measuring the concentrations of creatinine and creatine, with at least two calibration solutions being used, the electrode system for measuring the creatinine concentration is calibrated with a creatinine solution which, prior to the calibration measurement, was mixed in the form of an acidic solution with an alkaline buffer solution, and the electrode system for measuring the creatine concentration is calibrated with a solution in which creatinine and creatine are at a thermodynamic equilibrium.Type: ApplicationFiled: March 28, 2008Publication date: July 24, 2008Applicant: Roche Diagnostics Operations, Inc.Inventors: Bernhard Schaffar, Herbert Kroneis, Taghi Noormofidi, Gernot Florian, Wolf-Dietrich Steinbock
-
Patent number: 7371314Abstract: In a method for calibrating a biosensor for the amperometric determination of creatinine in biological liquids, consisting of one electrode system each for measuring the concentrations of creatinine and creatine, with at least two calibration solutions being used, the electrode system for measuring the creatinine concentration is calibrated with a creatinine solution which, prior to the calibration measurement, was mixed in the form of an acidic solution with an alkaline buffer solution, and the electrode system for measuring the creatine concentration is calibrated with a solution in which creatinine and creatine are at a thermodynamic equilibrium.Type: GrantFiled: August 9, 2001Date of Patent: May 13, 2008Assignee: Roche Diagnostics Operations, Inc.Inventors: Bernhard Schaffar, Herbert Kroneis, Taghi Noormofidi, Gernot Florian, Wolf-Dietrich Steinböck
-
Publication number: 20040072277Abstract: In a method for calibrating a biosensor for the amperometric determination of creatinine in biological liquids, consisting of one electrode system each for measuring the concentrations of creatinine and creatine, with at least two calibration solutions being used, the electrode system for measuring the creatinine concentration is calibrated with a creatinine solution which, prior to the calibration measurement, was mixed in the form of an acidic solution with an alkaline buffer solution, and the electrode system for measuring the creatine concentration is calibrated with a solution in which creatinine and creatine are at a thermodynamic equilibrium.Type: ApplicationFiled: November 26, 2003Publication date: April 15, 2004Inventors: Bernhard Schaffar, Herbert Kroneis, Taghi Noormofidi, Gernot Florian, Wolf-Dietrich Steinbock
-
Patent number: 6613205Abstract: An electrochemical sensor includes an electrochemically active sensor layer (sensor spot), which is applied by means of thick film techniques in at least one region of an electrically insulating, planar substrate, the surface of the sensor layer being brought into contact in a measuring area with the aqueous sample to be determined. At least one conductive path for signal pick-up is also applied on the substrate by means of thick film techniques. The sensor layer contains at least one oxide of metal from subgroups 7 and 8 wof the Periodic Table as sensor component. The contact between the electrochemically active sensor layer and the conductor is effected via an electrically conductive bridge layer which extends from the measuring area in a direction essentially parallel to the surface of the substrate. The bridge layer consists of corrosion-resistant material.Type: GrantFiled: March 3, 2000Date of Patent: September 2, 2003Assignee: F. Hoffmann-La Roche AGInventors: Gregor Steiner, Bernhard Schaffar, Marie-Luise Schinnerl, Christoph Ritter
-
Patent number: 6368478Abstract: An electrochemical measuring device comprises an essentially planar sensor substrate with at least one electrochemical sensor, and a cover part in which a tunnel-shaped measuring channel is formed. At least one guiding groove is provided in parallel with the measuring channel. A sealing element which is positioned between the sensor substrate and the cover part to seal the measuring channel is provided with guiding bodies along its length, at least one of which guiding bodies projects into the guiding groove of the cover part. The sealing element is provided with narrow sealing lips bounding the measuring channel. Each short side of the sealing element has a guiding body projecting into recesses in the sensor substrate. The guiding bodies are disposed on that side of a sealing plane defined by the sealing lips, which faces away from the cover part.Type: GrantFiled: September 15, 2000Date of Patent: April 9, 2002Assignee: F. Hoffmann La Roche AGInventors: Wolfgang Huber, Wolf-Dietrich Steinböck, Günther Pucher, Bernhard Schaffar, Christoph Ritter
-
Patent number: 6001228Abstract: A device for performing electrochemical and/or optical measurements in fluids, includes a sensor part of substantially planar configuration carrying a plurality of sensors that are connected to conductive paths; a cover part, which includes a groove-shaped measuring channel through which the fluid will flow; and a sealing element positioned between the sensor part and the cover part for sealing the measuring channel. The cover part includes grooves which extend in parallel with the measuring channel and which define respective ridges between the grooves and the measuring channel, and the sealing element substantially includes guiding bodies which are retained in the grooves of the cover part and are provided with integrally molded narrow sealing lips protruding in the area of the ridge. The sensor part and the cover part are joined by a plurality of locking elements which are distributed along the measuring channel.Type: GrantFiled: September 23, 1997Date of Patent: December 14, 1999Assignee: AVL Medical Instruments AGInventors: Wolfgang Huber, Andreas Dolezal, Bernhard Schaffar, Christoph Ritter
-
Patent number: 5928918Abstract: Biological components such as enzymes are immobilized in a three-dimensional cross-linked hydrophobic polymer. An enzyme is mixed with an aqueous solvent and a non-crosslinked prepolymer having an essentially nonpolar main chain with attached polar hydrophilic groups and cross-linking groups. The resultant mixture is exposed to cross-linking temperatures to react the prepolymer via the cross-linking groups without additional catalyst or cross-linking agents, and the aqueous solvent is evaporated to form a three-dimensional cross-linked hydrophobic polymer matrix containing the enzyme. The prepolymer can be an oil alkyl resin containing the main chain with attached polar hydrophilic groups and cross-linking groups. The oil alkyl resin is cross-linked by autoxidation, and aqueous solvent is evaporated to form the polymer matrix.Type: GrantFiled: April 14, 1997Date of Patent: July 27, 1999Assignee: AVL Medical Instruments AGInventors: Helmut Offenbacher, Bernhard Schaffar, Massoud Ghahramani
-
Patent number: 5683562Abstract: A planar sensor for determining a chemical parameter of a sample, includes a substrate whose surface is at least partly plane and is provided with at least one potentiometric or amperometric and, possibly, an optical transducer, and one or more biochemical components. The transducer and the biochemical component are provided on the surface of the substrate, or at least part of the surface, as a sensor spot, and a cover membrane surrounding this sensor spot, is heat welded to the surface of the substrate. Those sensor spots that include a potentiometric or amperometric transducer are in contact with a strip conductor attached to the plane surface of the substrate and the thermal seal of the cover membrane is interrupted where the conducting strips lead away from the sensor spots.Type: GrantFiled: September 14, 1995Date of Patent: November 4, 1997Assignee: AVL Medical Instruments AGInventors: Bernhard Schaffar, Heinz Kontschieder, Andreas Dolezal, Christoph Ritter
-
Patent number: 5351563Abstract: Method for analyzing gaseous or liquid samples, utilizing a one-way measuring element with a measuring channel containing at least one optical or electrochemical sensor and being provided with sealing elements on either end. In order to obtain accurate measurements in a simple manner the proposal is put forward that for measuring purposes a storage medium in the measuring channel be replaced by a separating medium which should then be replaced by the sample. Sample and storage medium will remain in the measuring element when it is discarded.Type: GrantFiled: April 9, 1993Date of Patent: October 4, 1994Assignee: AVL Medical Instruments AGInventors: Hellfried Karpf, M. Jean-Pierre Leiner, Anton Mostl, Klaus Reichenberger, Bernhard Schaffar, Werner E. Ziegler
-
Patent number: 5228350Abstract: Method for analysing gaseous or liquid samples, utilising a one-way measuring element with a measuring channel containing at least one optical or electrochemical sensor and being provided with sealing elements on either end. In order to obtain accurate measurements in a simple manner the proposal is put forward that for measuring purposes a storage medium in the measuring channel be replaced by a separating medium which should then be replaced by the sample. Sample and storage medium will remain in the measuring element when it is discarded.Type: GrantFiled: January 22, 1991Date of Patent: July 20, 1993Assignee: AVL Medical Instruments AGInventors: Hellfried Karpf, Marcus J. Leiner, Anton Mostl, Klaus Reichenberger, Bernhard Schaffar, Werner E. Ziegler
-
Patent number: D415839Type: GrantFiled: April 30, 1997Date of Patent: October 26, 1999Assignee: AVL Medical Instruments AGInventors: Wolfgang Huber, Andreas Dolezal, Bernhard Schaffar, Christoph Ritter