Patents by Inventor Bernhard Stump

Bernhard Stump has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Branched linker for protein drug conjugates
    Patent number: 10294270
    Abstract: The present invention relates to method for connecting a protein and a drug to a protein drug conjugate, wherein the drug is linked to the protein through a specific branched linker, said branched linker comprises a peptide chain and is derived from o-hydroxy p-amino benzylic alcohol, wherein the peptide chain is connected to the phenyl ring via the p-amino group, the drug is connected to the phenyl ring via the benzylic alcohol moiety, and the protein is connected to the phenyl ring via the o-hydroxy group; further to a process for the preparation of said protein-drug-conjugates via various intermediates, to the pharmaceutical use of such protein drug conjugates, such as methods of controlling the growth of undesirable cells, to pharmaceutical compositions comprising such protein drug conjugates, and to intermediates of the preparation of the protein drug conjugates.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: May 21, 2019
    Assignees: LONZA LTD, Lonza Guangzhou Nansha Ltd.
    Inventors: Laurent Ducry, Bernhard Stump, Heilam Wong, Jin She, Gayle Allway
  • Branched linker for protein drug conjugates
    Patent number: 10214560
    Abstract: The present invention relates to method for connecting a protein and a drug to a protein drug conjugate, wherein the drug is linked to the protein through a specific branched linker, said branched linker comprises a peptide chain and is derived from o-hydroxy p-amino benzylic alcohol, wherein the peptide chain is connected to the phenyl ring via the p-amino group, the drug is connected to the phenyl ring via the benzylic alcohol moiety, and the protein is connected to the phenyl ring via the o-hydroxy group; further to a process for the preparation of said protein-drug-conjugates via various intermediates, to the pharmaceutical use of such protein drug conjugates, such as methods of controlling the growth of undesirable cells, to pharmaceutical compositions comprising such protein drug conjugates, and to intermediates of the preparation of the protein drug conjugates.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: February 26, 2019
    Assignees: LONZA LTD, Lonza Guangzhou Nansha Ltd.
    Inventors: Laurent Ducry, Bernhard Stump, Heilam Wong, Jin She, Gayle Allway
  • Branched Linker for Protein Drug Conjugates
    Publication number: 20180258136
    Abstract: The present invention relates to method for connecting a protein and a drug to a protein drug conjugate, wherein the drug is linked to the protein through a specific branched linker, said branched linker comprises a peptide chain and is derived from o-hydroxy p-amino benzylic alcohol, wherein the peptide chain is connected to the phenyl ring via the p-amino group, the drug is connected to the phenyl ring via the benzylic alcohol moiety, and the protein is connected to the phenyl ring via the o-hydroxy group; further to a process for the preparation of said protein-drug-conjugates via various intermediates, to the pharmaceutical use of such protein drug conjugates, such as methods of controlling the growth of undesirable cells, to pharmaceutical compositions comprising such protein drug conjugates, and to intermediates of the preparation of the protein drug conjugates.
    Type: Application
    Filed: March 23, 2018
    Publication date: September 13, 2018
    Inventors: Laurent Ducry, Bernhard Stump, Heilam Wong, Jin She, Gayle Allway
  • Branched Linker for Protein Drug Conjugates
    Publication number: 20130324706
    Abstract: The present invention relates to method for connecting a protein and a drug to a protein drug conjugate, wherein the drug is linked to the protein through a specific branched linker, said branched linker comprises a peptide chain and is derived from o-hydroxy p-amino benzylic alcohol, wherein the peptide chain is connected to the phenyl ring via the p-amino group, the drug is connected to the phenyl ring via the benzylic alcohol moiety, and the protein is connected to the phenyl ring via the o-hydroxy group; further to a process for the preparation of said protein-drug-conjugates via various intermediates, to the pharmaceutical use of such protein drug conjugates, such as methods of controlling the growth of undesirable cells, to pharmaceutical compositions comprising such protein drug conjugates, and to intermediates of the preparation of the protein drug conjugates.
    Type: Application
    Filed: February 23, 2012
    Publication date: December 5, 2013
    Inventors: Laurent Ducry, Bernhard Stump, Heilam Wong, Jin She, Gayle Phillips