Abstract: Disclosed herein is a delivery system for delivering a leadless pacemaker. The delivery system may include a catheter, which may be a guide catheter. The catheter includes a distal end, a proximal end opposite the distal end, a lumen extending between the distal end and the proximal end, and a locking hub operably coupled to the proximal end. The locking hub includes a lumen segment of the lumen. In one implementation, self-biasing of the lumen segment places the lumen segment out of alignment with a rest of the lumen. Deflecting the lumen segment against the self-biasing of the lumen segment places the lumen segment in coaxial alignment with the rest of the lumen. In another implementation, self-biasing of the lumen segment reduces an inner diameter of the lumen segment and actuation of the locking hub expands the inner diameter.

Abstract: The present invention refers to a sgRNA molecule comprising a targeting domain for specifically targeting a SNP in the BEST1 coding region of a pathologic allele, wherein said targeting domain consists of a sequence selected from the group consisting of SEQ ID NO: 3-8, 41-44, 14-20, 50-52 and 54-55, or a sgRNA molecule combination of specifically defined first and second sgRNA molecules, wherein the first and the second sgRNA molecule each comprise a targeting domain for specifically targeting a SNP in the BEST1 gene coding or non-coding region of a pathologic allele. The present invention also refers to a nucleic acid comprising a sequence that encodes the sgRNA molecule or sgRNA molecule combination and to nucleic acid combinations. The present invention further relates to a recombinant adenovirus-associated vims (AAV) comprising the nucleic acids according to the present invention or recombinant AAV combinations.

Abstract: A cabinet pull-out comprises a first storage compartment and a second storage compartment and a pull-out frame, the pull-out frame connecting the first storage compartment to the second storage compartment. The first and the second storage compartment each are provided with a base. The pull-out frame comprises a single carrier element which extends essentially rectangularly to the base area of the corresponding storage compartment. Each of the first and second storage compartments are provided with a front wall and a rear wall and two side walls each extending between the front wall and the rear wall. The single carrier element is attached to an external side of the rear wall or one of the side walls. A loose storage compartment can be detachably coupled to one of the first or second storage compartments.

Abstract: The present invention refers to Biochanin A derivative as defined in formula (II) or a salt thereof for use in a method of treating or preventing BEST1-related retinopathies such as autosomal dominant Best vitelliform macular dystrophy. The present invention also refers to a pharmaceutical composition comprising a Biochanin A derivative as defined in formula (II) or a salt thereof and a pharmaceutical acceptable excipient and/or carrier for use in a method of treating or preventing BEST1-related retinopathies such as autosomal dominant Best vitelliform macular dystrophy.

Abstract: A cabinet pull-out comprises a first storage compartment and a second storage compartment and a pull-out frame, the pull-out frame connecting the first storage compartment to the second storage compartment. The first and the second storage compartment each are provided with a base. The pull-out frame comprises a single carrier element which extends essentially rectangularly to the base area of the corresponding storage compartment. Each of the first and second storage compartments are provided with a front wall and a rear wall and two side walls each extending between the front wall and the rear wall. The single carrier element is attached to an external side of the rear wall or one of the side walls. A loose storage compartment can be detachably coupled to one of the first or second storage compartments.

Abstract: A cabinet pull-out comprises a first storage compartment and a second storage compartment and a pull-out frame, the pull-out frame connecting the first storage compartment to the second storage compartment. The first and the second storage compartment each are provided with a base. The pull-out frame comprises a carrier element which extends essentially rectangularly to the base area of the corresponding storage compartment. Each of the first and second storage compartments are provided with a front wall and a rear wall and two side walls each extending between the front wall and the rear wall. The carrier element is attached to an external side of the rear wall or one of the side walls. A loose storage compartment can be detachably coupled to one of the first or second storage compartments.

Abstract: An emitter system for the irradiation of laminated glass panels of different widths, a glass cutting device for processing laminated glass panels of different widths with such an emitter system, a manufacturing method for such an emitter system, and a use of such an emitter system for the irradiation of laminated glass panels of different widths. The emitter system includes a plurality of elongated emitters. The elongated emitters are arranged one behind the other on a common longitudinal axis. The elongated emitters each have two ends, which are angled in relation to the common longitudinal axis. The emitter system is arranged in a glass cutting device.

Abstract: The invention relates to a rack comprising at least one longitudinal profile, which can be vertically aligned, to which retaining means can be attached, into which trays, cabinet elements or other shelf elements can be inserted, which retaining means are held in clamping fashion via clamping jaws on the longitudinal profile. The clamping jaws are attached to a first plate-shaped based body and to a second plate-shaped base body, which are arranged lying one atop the other and can be moved against each other, guided by guiding means, and as a result the clamping jaws can be tensioned against lateral surfaces of the longitudinal profile. A rotation axle of an eccentric for moving the clamping jaws is rotatably mounted in the first plate-shaped base body and the eccentric body protrudes into a recess of the second plate-shaped base body. A simply designed retaining means is thus obtained which can be easily clamped on the longitudinal profile.

Abstract: A cabinet pull-out comprises a first storage compartment and a second storage compartment and a pull-out frame, the pull-out frame connecting the first storage compartment to the second storage compartment. The first and the second storage compartment each are provided with a base. The pull-out frame comprises a carrier element which extends essentially rectangularly to the base area of the corresponding storage compartment. Each of the first and second storage compartments are provided with a front wall and a rear wall and two side walls each extending between the front wall and the rear wall. The carrier element is attached to an external side of the rear wall or one of the side walls. A loose storage compartment can be detachably coupled to one of the first or second storage compartments.

Abstract: A radiator module is provided including: a first infrared radiator including a first radiator tube arranged in a radiator plane; and a second infrared radiator including a second radiator tube arranged in the radiator plane. A cladding tube is arranged between the first radiator tube and the second radiator tube. Each of the first radiator tube, the second radiator tube, and the cladding tube is provided with a reflective coating.

Abstract: A storage compartment is formed from a blank made of sheet metal and comprises a base part and edge regions surrounding the base part, which edge regions are bent upwards by about 90° with respect to the base part. The upwardly bent edge regions are equipped with receiving and holding means, in each of which a plate-shaped element is insertable and is held. One each of a first edge region and a second edge region form a first side surface and a second side surface. The first side surface serves as a supporting surface for the plate-shaped element. The second side surface covers the frontal surface of the plate-shaped element. Furthermore, a projecting element is provided in the second side surface. The plate-shaped element is held between the supporting surface and the projecting element.

Abstract: The invention relates to a rack comprising at least one longitudinal profile, which can be vertically aligned, to which retaining means can be attached, into which trays, cabinet elements or other shelf elements can be inserted, which retaining means are held in clamping fashion via clamping jaws on the longitudinal profile. The clamping jaws are attached to a first plate-shaped based body and to a second plate-shaped base body, which are arranged lying one atop the other and can be moved against each other, guided by guiding means, and as a result the clamping jaws can be tensioned against lateral surfaces of the longitudinal profile. A rotation axle of an eccentric for moving the clamping jaws is rotatably mounted in the first plate-shaped base body and the eccentric body protrudes into a recess of the second plate-shaped base body. A simply designed retaining means is thus obtained which can be easily clamped on the longitudinal profile.

Abstract: A storage compartment is formed from a blank made of sheet metal and comprises a base part and edge regions surrounding the base part, which edge regions are bent upwards by about 90° with respect to the base part. The upwardly bent edge regions are equipped with receiving and holding means, in each of which a plate-shaped element is insertable and is held. One each of a first edge region and a second edge region form a first side surface and a second side surface. The first side surface serves as a supporting surface for the plate-shaped element. The second side surface covers the frontal surface of the plate-shaped element. Furthermore, a projecting element is provided in the second side surface. The plate-shaped element is held between the supporting surface and the projecting element.

Abstract: A mobile facility, and relates methods, for producing an inorganic particulate material comprising: one or more grinders; a feeder for providing feed material to the one or more grinders; and auxiliary apparatus; wherein the facility is configured or adapted to produce an inorganic particulate material whereby the particle size of the feed material is reduced by a ratio of at least about 10:1, or about 100:1, or about 1,000:1 to produce the inorganic particulate material.

Abstract: A radiator module is provided including: a first infrared radiator including a first radiator tube arranged in a radiator plane; and a second infrared radiator including a second radiator tube arranged in the radiator plane. A cladding tube is arranged between the first radiator tube and the second radiator tube. Each of the first radiator tube, the second radiator tube, and the cladding tube is provided with a reflective coating.

Abstract: The present invention relates to compositions for use in an aqueous pulp bleaching process, comprising one or more alkaline earth metal oxides and/or one or more alkaline earth metal hydroxides; one or more alkaline earth metal salts; and optionally, one or more pitch control additives. Methods and kits for the formation of said compositions, are also part of the invention, as is the use of said compositions, methods and kits.

Abstract: The present invention relates to the preparation and use of recombinant variants of group 5 allergens of the Poaceae (true grasses), which are characterized by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.

Abstract: The present invention relates to the preparation and use of recombinant variants of group 5 allergens of the Poaceae (true grasses), which are characterised by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.

Abstract: The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies.

Abstract: The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies.