Abstract: The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.

Abstract: The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.

Abstract: The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.

Abstract: The invention provides a human GSK3B which is associated with cardiovascular diseases, cancer, metabolic diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, metabolic diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GSK3B as well as pharmaceutical compositions comprising such compounds.

Abstract: The invention provides a human NPFF1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma and genito-urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma and genito-urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of NPFF1 as well as pharmaceutical compositions comprising such compounds.

Abstract: The invention provides a human NPFF2 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma, and genito-urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma, and genito-urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of NPFF2 as well as pharmaceutical compositions comprising such compounds.

Abstract: Miniaturized spectrometer in the form of a probe for determining ingredients of a gaseous or liquid fluid with a light source and a spectrometer, at least one measurement beam, and at least one reference beam. Light from the light source is optionally fanned out and focused, by at least one optical lens, in an essentially parallel beam. At least one measurement beam is passed through a light transparent window from the probe into the fluid being investigated and through an additional light transparent window back in to the probe, and at least one reference beam is guided in the probe interior. A collecting optics device, comprising at least one lens, diverts the beams to the impingement point of the light guide or the inlet of the spectrometer, and a beam selector in the area of the collecting optics device passes through one of the partial beams and interrupts all the others.

Abstract: A jack plug for a cable having a center conductor and at least one shielding conductor surrounding the center conductor comprises a plug shaft having the electric plug contact elements at the front side of the jack plug, a receiving space which opens toward the rear of the jack plug and in which the cable can be inserted and in which the inserted cable can be fixed, electric cable contact elements which communicate with the plug contact elements for making electrical contact with the conductors of the cable, at least one of which electric cable contact elements has a knife edge or tip by which a conductor ending at the front end of the inserted cable can make contact, wherein at least one electric cable contact element having a knife edge or tip is mounted so as to be displaceable and a spring is provided for pushing the cable contact element against the conductor of the inserted cable.

Abstract: The invention concerns a miniaturized spectrometer, especially in the form of a probe, for determination of the ingredients of a gaseous or liquid fluid with a light source (3) and a spectrometer (2), at least one measurement beam and at least one reference beam.

Abstract: This invention relates to a plug part of a BNC plug-and-socket connection for a coaxial cable, which contains an external and an internal conductor, with plug body (1), comprising an external contact part (5) arranged in the front in relation to the direction of plugging, a connection zone (6) for fixing the external conductor of the coaxial cable, located at the back and connected in an electrically conductive manner with external contact part (5), and an internal insulated part (8) comprising a central aperture (9) for a contact pin (10), to which the internal conductor of a coaxial cable is to be connected, and a bayonet-type bushing (2) arranged on plug body (1) in a twistable manner, and furthermore, a manipulation casing (19) designed as a separate part, which is connected with bayonet-type bushing (2) in a firm, untwistable manner, overlaps connection zone (6) of plug part (1) at its rear side, and is used to open and close the BNC plug-and-socket connection through bayonet-type bushing (2).

Abstract: The cable connector for electrical connections has a connector housing and a connector insert which is made of electrically insulating material and has contact elements, and a pull relief for the cable to be connected. This pull relief is formed by a swivel jaw. The surface of the swivel jaw cooperating with the cable is rounded in an arc-shaped manner and is formed with teeth. The swivel plane of the swivel jaw lies in or parallel to the longitudinal axis of the cable connector. The connector insert is formed of at least two parts, wherein the first part has a portion having the contact elements and a channel-like portion adjoining the rear side of portion, with an electrically conducting insert extending along part of the length of the channel-like portion. This electrically conducting insert extends until the portion of the first part having the contact elements to form a ground contact. The other, second part of the connector insert is connectable with the channel-like portion of the first part.

Abstract: A jack plug has a contact tip provided at the free end and followed by a connection part which is received by a tubular shaft of the jack plug. The contact tip with the connection part is electrically insulated from the shaft. At the side remote of the contact tip, the shaft has a handle part through which the connecting cable runs. The connection part which is formed in one piece with the contact tip has a bore hole which penetrates it over its entire length and which extends into the interior of the contact tip. The conductor of the cable to be connected can be secured in the interior of the contact tip by a material engagement or a positive engagement (crimping). The portion of the bore hole located in the contact tip is filled with a solder and, if required, with flux. A zone of the handle part is grooved or knurled on its inner side. This zone is narrowed in diameter by radial squeezing (crimping) after the cable to be connected is inserted.

Abstract: A jack socket for a jack plug has a tubular guide part for receiving the shaft of the jack plug and a holder made from electrically insulating material with contact strips arranged therein. The contact strips have solder lugs which project beyond the holder and can be connected in an electrically conducting manner with the conductors of a printed circuit board. The tubular guide part can be fastened in a bore hole of a housing of a device having the jack socket. The holder grasps the contact strips and, as the case may be, the switching contacts in the immediate region of the solder lugs. The height of the holder amounts to only a portion of the height of the contact strips. The guide part and the holder with the contact strips are separated from one another. The holder is disk-shaped or plate-shaped.

Abstract: The electrical plug-in connector for electric leads comprises a cable plug and a chassis receptacle. The cable plug and chassis receptacle each have a housing with preferably flat contacts. The contacts of the cable plug are arranged at inner surfaces of legs of a U-shaped or frame-shaped part of the housing, which inner surfaces face one another. A wedge-shaped receiving space is cut out in the chassis receptacle for receiving this U-shaped or frame-shaped part. A nose-shaped projection is provided at one of the converging side surfaces of this receiving space, this nose-shaped projection projecting across from the other side surface. Contacts are arranged at the boundary surfaces of the latter which are disposed at right angles to the opposite side surface. The front side of this nose-shaped projection is arranged at a distance from the adjacent side surface.

Abstract: A jack plug has a contact tip provided at the free end and followed by a connection part which is received by a tubular shaft of the jack plug. The contact tip with the connection part is electrically insulated from the shaft. At the side remote of the contact tip, the shaft has a handle part through which the connecting cable runs. The connection part which is formed in one piece with the contact tip has a bore hole which penetrates it over its entire length and which extends into the interior of the contact tip. The conductor of the cable to be connected can be secured in the interior of the contact tip by a material engagement or a positive engagement (crimping). The portion of the bore hole located in the contact tip is filled wit a solder and, if required, with flux. A zone of the handle part is grooved or knurled on its inner side. This zone is narrowed in diameter by radial squeezing (crimping) after the cable to be connected is inserted.

Abstract: The holder is used for a notepad formed of a stack of note slips which are connected with one another at one of their edges. It has a concave, arc-shaped or gutter-shaped support for the notepad. This support has two edges parallel to its imaginary generating straight line. These two edges project away from the concave support surface. One of the edges has a height (h) which corresponds roughly to the height of the notepad to be received by the holder. The distance (A) between the two edges measured along the concave support corresponds to the width (B) of the notepad to be received. The edge whose height (h) corresponds roughly to the height of the notepad projects away from the concave support approximately at a right angle.

Abstract: The contact element for electrical connectors, in particular for audio connectors, is stamped out of a starting material in sheet form. It has two fork-like legs having projections directed opposite one another at their free ends for the purpose of making contact diametrically with a contact element in the shape of a pin or strip which can be inserted between the fork-like legs. The contact-making boundary edges of the projections extend in a straight line. When the contact element is not loaded, these straight boundary edges enclose an acute angle with the center axis of the contact element, which acute angle corresponds to the deflecting angle of the legs when the pin-shaped or strip-shaped contact element is inserted. The portion of the contact element remote of the projections is constructed as a curve and a web leading to the terminal lug of the contact element adjoins the central portion of this curve. The contact element is substantially shaped like a tuning fork.

Abstract: A jack plug has a plug housing formed by two shells and a cable bushing which can be screwed on a thread provided at the plug housing and penetrated by the cable to be connected. The outer contact shaft is formed integral with one shell of the plug housing, which shell is formed of metallic material. The outer contact shaft or its longitudinal axis is disposed at right angles to the dividing plane of the plug housing. A cylindrical neck which has the thread and is substantially closed circumferentially is provided at the end of one shell. A hook-like abutment is formed on at the end of the shell located opposite this neck. The other shell has a cut out portion at one end for receiving the abutment. At its other end side is arranged a pin-like projection which is received in a correspondingly constructed slot provided in the neck having the thread. The cable bushing screwed onto the thread engages in a positive locking manner over this slot and the projection received by the latter.

Abstract: A jack plug has a contact bulb provided at its free end having a contact shaft serving for the electrical connection of an electrical conductor. The contact shaft penetrates the center of a tubular shaft of the plug serving as an external contact. An insulating material is provided between the contact shaft of the contact bulb and the tubular shaft. The shaft serving as external contact continues into a portion at the side remote from the contact bulb. The portion extends beyond the inner end of the insulating tube and has a greater diameter than the shaft. This portion is received by a gripping sleeve. The portion has axially parallel notches proceeding from its free front side. These front sides of the portion contact corresponding inner surfaces of the gripping sleeve which is screwed on by means of an internal thread. The notches extend substantially along the entire axial length of the portion. The internal thread of the gripping sleeve is provided at the side facing the contact bulb.