Patents by Inventor Bernhardt Levy Trout
Bernhardt Levy Trout has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11340014Abstract: The disclosure in some aspects relates to systems and related methods for the continuous freeze-drying of materials (e.g., pharmaceuticals) with high speed and control.Type: GrantFiled: May 2, 2018Date of Patent: May 24, 2022Assignees: Massachusetts Institute of Technology, Politecnico di TorinoInventors: Bernhardt Levy Trout, Roberto Pisano, Luigi Carlo Capozzi
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Publication number: 20220062180Abstract: System and methods related to lyophilization of pharmaceutical products are disclosed. In some embodiments, vials of product are moved through a system using one or more movers which are electromagnetically levitated and moved through the system without making mechanical contact with each other or the system. Load lock chambers may allow a mover to enter from one process region's environment and then be brought to an environment condition of the next process region to allow materials to be passed through conditioning, nucleation, and/or vacuum drying regions prior to finally exit the system to an unloading zone. The movers may then be cleaned or reloaded with vials to begin the process again with a new load of vials.Type: ApplicationFiled: June 25, 2021Publication date: March 3, 2022Applicant: Massachusetts Institute of TechnologyInventors: Alexander H. Slocum, Bernhardt Levy Trout
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Publication number: 20210180865Abstract: The disclosure in some aspects relates to systems and related methods for the continuous freeze-drying of materials (e.g., pharmaceuticals) with high speed and control.Type: ApplicationFiled: May 2, 2018Publication date: June 17, 2021Applicants: Massachusetts Institute of Technology, Politecnico di TorinoInventors: Bernhardt Levy Trout, Roberto Pisano, Luigi Carlo Capozzi
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Patent number: 10762980Abstract: Provided herein are high-throughput methods for identifying a candidate antibody based on viscosity of the candiate antibody.Type: GrantFiled: May 16, 2014Date of Patent: September 1, 2020Assignees: Massachusetts Institute of Technology, Novartis Pharma AGInventors: Bernhardt Levy Trout, Bernhard Helk, Neeraj Jagdish Agrawal
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Patent number: 10703048Abstract: Methods and apparatuses for bonding polymeric parts are disclosed. Specifically, in one embodiment, the polymeric parts are bonded by plastically deforming them against each other while they are below the glass transition temperatures.Type: GrantFiled: December 21, 2018Date of Patent: July 7, 2020Assignee: Massachusetts Institute of TechnologyInventors: Nikhil Padhye, David Moore Parks, Bernhardt Levy Trout, Alexander H. Slocum
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Publication number: 20200158431Abstract: The disclosure in some aspects relates to systems and related methods for the continuous freeze-drying of materials (e.g., pharmaceuticals) with high speed and control.Type: ApplicationFiled: May 2, 2018Publication date: May 21, 2020Applicants: Massachusetts Institute of Technology, Politecnico di TorinoInventors: Bernhardt Levy Trout, Roberto Pisano, Luigi Carlo Capozzi
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Publication number: 20190134916Abstract: Methods and apparatuses for bonding polymeric parts are disclosed. Specifically, in one embodiment, the polymeric parts are bonded by plastically deforming them against each other while they are below the glass transition temperatures.Type: ApplicationFiled: December 21, 2018Publication date: May 9, 2019Applicant: Massachusetts Institute of TechnologyInventors: Nikhil Padhye, David Moore Parks, Bernhardt Levy Trout, Alexander H. Slocum
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Patent number: 10213960Abstract: Methods and apparatuses for bonding polymeric parts are disclosed. Specifically, in one embodiment, the polymeric parts are bonded by plastically deforming them against each other while they are below the glass transition temperatures. A method includes: placing a first polymeric part in contact with a second polymeric part; and plastically deforming the first polymeric part and the second polymeric part against each other to bond the first polymeric part to the second polymeric part. Additionally, during the plastic deformation, a temperature of the first polymeric part is less than a glass transition temperature of the first polymeric part and a temperature of the second polymeric part is less than a glass transition temperature of the second polymeric part.Type: GrantFiled: May 20, 2015Date of Patent: February 26, 2019Assignee: Massachusetts Institute of TechnologyInventors: Nikhil Padhye, David Moore Parks, Bernhardt Levy Trout, Alexander H. Slocum
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Patent number: 10053798Abstract: Methods and systems for manufacturing a tablet are generally provided. Certain embodiments comprise electrodepositing (e.g., electrospinning) a material (e.g., the tablet material, for example, within a fluid) onto a substrate. The substrate can be, for example, an elongated rod. In some such embodiments, after material has been electrodeposited onto the substrate, a die comprising a cavity and the substrate can be moved relative to each other such that the electrodeposited material is at least partially stripped from the substrate and/or at least partially deposited into the cavity of the die. Some embodiments comprise compressing the material in the cavity to form a tablet.Type: GrantFiled: April 30, 2015Date of Patent: August 21, 2018Assignee: Massachusetts Insititute of TechnologyInventors: Alexander H. Slocum, Nicholas M. Sondej, Bernhardt Levy Trout, Gregory C. Rutledge, Indrani Bhattacharyya
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Publication number: 20180071215Abstract: Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. The polymer matrix may influence at least a portion of the crystallization process and/or the resulting composition. In some such embodiments, the polymer matrix allows one or more aspect of the process and/or composition to be controlled and/or altered. For instance, the polymer matrix may act as a crystallization promoter and/or acceptable carriers of the crystallized agent. In certain embodiments, the polymer matrix described herein, can be used with any agent regardless of its chemical and/or physical properties.Type: ApplicationFiled: September 22, 2017Publication date: March 15, 2018Applicant: Massachusetts Institute of TechnologyInventors: Bernhardt Levy Trout, Patrick S. Doyle, Allan S. Myerson, Paul Douglas Godfrin, Abu Zayed Md Badruddoza
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Publication number: 20170354609Abstract: The disclosure describes an injection molding process for coating a tablet core to produce a coated pharmaceutical tablet, wherein the injection-molded coating is substantially continuous (e.g., completely covers the tablet core with no openings), and describes the resulting coated pharmaceutical tablet. The disclosure describes compositions for coatings and tablet cores and equipment suitable for performing the process.Type: ApplicationFiled: June 12, 2017Publication date: December 14, 2017Applicant: Massachusetts Institute of TechnologyInventors: Vibha Puri, Parind Mahendrakumar Desai, Keith D. Jensen, David Brancazio, Eranda Harinath, Alexander Racine Martinez, Jung Hoon Chun, Richard Dean Braatz, Allan S. Myerson, Bernhardt Levy Trout
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Patent number: 9822467Abstract: The present invention generally relates to methods and systems relating to the selection of substrates comprising crystalline templates for the controlled crystallization of molecular species. In some embodiments, the methods and systems allow for the controlled crystallization of a molecular species in a selected polymorphic form. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent).Type: GrantFiled: November 15, 2012Date of Patent: November 21, 2017Assignee: Massachusetts Institute of TechnologyInventors: Keith Chadwick, Bernhardt Levy Trout, Allan Stuart Myerson
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Patent number: 9777067Abstract: The invention provides HER2-binding proteins and VEGF-A-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided.Type: GrantFiled: September 27, 2013Date of Patent: October 3, 2017Assignee: Massachusetts Institute of TechnologyInventors: Bernhardt Levy Trout, Curtiss Paul Schneider, Neeraj Jagdish Agrawal
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Publication number: 20170114127Abstract: The present disclosure provides VEGF-A-binding proteins and HER-2-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided.Type: ApplicationFiled: October 21, 2016Publication date: April 27, 2017Applicant: Massachusetts Institute of TechnologyInventors: Bernhardt Levy Trout, Neeraj Jagdish Agrawal, Fabienne Courtois
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Publication number: 20170080637Abstract: Methods and apparatuses for bonding polymeric parts are disclosed. Specifically, in one embodiment, the polymeric parts are bonded by plastically deforming them against each other while they are below the glass transition temperatures. A method includes: placing a first polymeric part in contact with a second polymeric part; and plastically deforming the first polymeric part and the second polymeric part against each other to bond the first polymeric part to the second polymeric part. Additionally, during the plastic deformation, a temperature of the first polymeric part is less than a glass transition temperature of the first polymeric part and a temperature of the second polymeric part is less than a glass transition temperature of the second polymeric part.Type: ApplicationFiled: May 20, 2015Publication date: March 23, 2017Applicant: Massachusetts Institute to TechnologyInventors: Nikhil Padhye, David Moore Parks, Bernhardt Levy Trout, Alexander H. Slocum
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Publication number: 20160319464Abstract: Methods and systems for manufacturing a tablet are generally provided. Certain embodiments comprise electrodepositing (e.g., electrospinning) a material (e.g., the tablet material, for example, within a fluid) onto a substrate. The substrate can be, for example, an elongated rod. In some such embodiments, after material has been electrodeposited onto the substrate, a die comprising a cavity and the substrate can be moved relative to each other such that the electrodeposited material is at least partially stripped from the substrate and/or at least partially deposited into the cavity of the die. Some embodiments comprise compressing the material in the cavity to form a tablet.Type: ApplicationFiled: April 30, 2015Publication date: November 3, 2016Applicant: Massachusetts Institute of TechnologyInventors: Alexander H. Slocum, Nicholas M. Sondej, Bernhardt Levy Trout, Gregory C. Rutledge, Indrani Bhattacharyya
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Publication number: 20160289173Abstract: The present invention generally relates to devices and methods for crystallizing a compound. In certain industries, crystallization techniques require additional filtration steps in order to obtain products of relatively high yield and/or high purity. In some embodiments, the devices and methods described herein facilitate continuous production of high yield and/or high purity products without the need for additional filtration steps. In some embodiments, the devices and methods comprise flowing a fluid comprising a compound (e.g., a crystallizable compound, a solidifiable compound) over a substrate such that the compound crystallizes and/or precipitates on the substrate. In some embodiments, the crystallized compound can be recovered (e.g., at a high purity in solution). In certain embodiments, the substrate is orientated substantially vertically (e.g., such that flow of the fluid is driven by gravity). In some cases, the substrate comprises a plurality of crystallization promoting structures.Type: ApplicationFiled: March 30, 2016Publication date: October 6, 2016Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: ALLAN STUART MYERSON, RICHARD DEAN BRAATZ, STEVEN THOMAS FERGUSON, MIN SU, BERNHARDT LEVY TROUT, LIFANG ZHOU, NIMA YAZDAN PANAH
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Publication number: 20160279246Abstract: Methods of heterogeneous crystallization and related systems are provided. In some embodiments, a method comprises crystallizing an agent in a suspension comprising a heteronucleant and the dissolved agent. Crystallization may occur on the surface of the heteronucleant with little or no bulk crystallization and/or secondary nucleation. In some embodiments, a crystallizer may be configured to inhibit secondary nucleation and/or bulk crystallization, for example, by reducing the formation of free crystals that may serve as nucleation surfaces while allowing for adequate mass and heat transfer. In some such embodiments, the crystallizer may be designed to flow (e.g., continuously) a suspension comprising a heteronucleant and an agent in a fluidized state. The methods and systems of the present invention may be used in a wide variety of applications, including the crystallization of pharmaceutically active agents.Type: ApplicationFiled: February 26, 2016Publication date: September 29, 2016Applicant: Massachusetts Institute of TechnologyInventors: Bernhardt Levy Trout, Allan Stuart Myerson, Siva Rama Krishna Perala, Christopher James Testa, Keith Dale Jensen
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Publication number: 20160132634Abstract: The invention provides computer-implemented methods for screening proteins such as antibodies based on viscosity properties. The methods involve making a spatial charge map (SCM) of the three-dimensional structure of the antibody or protein and determine a SCM score depending on a condition such as e.g. pH, which score correlates with the viscosity. Thus a quantitative measure of the viscosity is obtained.Type: ApplicationFiled: May 16, 2014Publication date: May 12, 2016Applicants: Massachusetts Institute of Technology, Novartis Pharma AGInventors: Bernhardt Levy Trout, Bernhard Helk, Neeraj Jagdish Agrawal
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Publication number: 20160129019Abstract: The present invention generally relates to compositions, methods, and systems relating to controlled crystallization and/or nucleation of a molecular species. In some embodiments, the crystallization and/or nucleation of the molecular species may be controlled by tuning the surface chemistry and/or the morphology of a crystallization substrate. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent).Type: ApplicationFiled: July 24, 2015Publication date: May 12, 2016Inventors: Bernhardt Levy Trout, Patrick S. Doyle, Trevor Alan Hatton, Allan Stuart Myerson, Ying Diao, Matthew E. Helgeson