Patents by Inventor Bernie J. Devlin

Bernie J. Devlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxygen sensing and hypoxic selection for tumors
    Patent number: 6468789
    Abstract: The present invention is directed to oxygen sensing. The present invention provides methods for correcting (or providing for) oxygen sensing in cells. Preferably, the methods involve supplying the SDHD gene or cybS protein, or any of the other components of the mitochondrial complex II cytochrome b oxygen sensing complex in an amount which restores oxygen sensing to affected cells, and thus facilitates normoxic conditions. More specifically, the present invention relates to mutations in the SDHD gene in human cancers and their use in the diagnosis and prognosis of mammalian cancer.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: October 22, 2002
    Assignee: University of Pittsburgh
    Inventors: Bora E. Baysal, Robert E. Ferrell, Bernie J. Devlin, Joan E. Willett-Brozick