Patents by Inventor Bernward Scholkens

Bernward Scholkens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hetero-imino-prostacyclins
    Patent number: 4371542
    Abstract: What are disclosed are prostacylin PGI.sub.2 analogs of the formula ##STR1## having a more specific or longer lasting pharmacological action than PGI.sub.2, methods of making these analogs; and methods and pharmaceutical preparations for inhibiting blood platelet aggregation, for treating hypertension, for the treatment or prophylaxis of gastrointestinal ulcers, and for the treatment of asthma.
    Type: Grant
    Filed: February 20, 1981
    Date of Patent: February 1, 1983
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Beck, Jochen Knolle, Richard H. Rupp, Bernward Scholkens
  • Thienyoxy and furyl containing analogs of prostacyclin and their use as medicaments
    Patent number: 4312882
    Abstract: What is disclosed are prostacyclin analogs of the general formula I ##STR1## which have a more specific action and/or a longer action than the naturally occurring prostacyclin PGI.sub.2, as well as intermediate products for their preparation and a process for their preparation. The compounds of formula I are distinguished by inhibitory action on thrombocyte aggregation and by relaxation of the vascular walls, in particular of the coronary arteries. They can thus be used as medicaments.
    Type: Grant
    Filed: January 23, 1980
    Date of Patent: January 26, 1982
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wilhelm Bartmann, Elmar Konz, Ulrich Lerch, Bernward Scholkens
  • Thienyl, thienyloxy or furyl substituted prostaglandin derivatives in the 6-keto-PGE.sub.1 series
    Patent number: 4304783
    Abstract: The invention relates to new prostaglandin derivatives of the 6-keto-PGE.sub.1 series, to processes and intermediates for their manufacture and to their use as medicaments.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: December 8, 1981
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Beck, Ulrich Lerch, Bernward Scholkens, Richard H. Rupp
  • Esters of 5-methyl-10,11-dihydroprostaglandin-A.sub.1
    Patent number: 4198429
    Abstract: Prostaglandin esters of the formula ##STR1## have valuable therapeutical properties.
    Type: Grant
    Filed: June 23, 1977
    Date of Patent: April 15, 1980
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wilhelm Bartmann, Gerhard Beck, Ulrich Lerch, Bernward Scholkens
  • Novel prostaglandin derivatives
    Patent number: 4182773
    Abstract: What is disclosed are prostaglandin-analogous cyclopentane derivatives of the formula I ##STR1## wherein R.sup.1 is hydrogen or a linear or branched, saturated or unsaturated aliphatic or cycloaliphatic radical having from 1 to 8 carbon atoms, or an araliphatic radical having from 7 to 9 carbon atoms, or a physiologically tolerable metal, NH.sub.4 or substituted ammonium ion derived from a primary, secondary or tertiary amine;R.sup.2 is a linear or branched, saturated or unsaturated aliphatic hydrocarbon radical having from 1 to 8 carbon atoms;R.sup.3 is hydrogen or a R.sup.4 CO group wherein R.sup.4 is a hydrogen atom or a linear or branched alkyl group having up to 10 carbon atoms;A is a saturated, linear or branched alkylene group having from 2 to 5 carbon atoms, and a process for the manufacture thereof.
    Type: Grant
    Filed: July 15, 1977
    Date of Patent: January 8, 1980
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wilhelm Bartmann, Ulrich Lerch, Hermann Teufel, Bernward Scholkens, Gerhard Beck
  • Certain pyrrolidone derivatives and pharmaceutical use thereof
    Patent number: 4079145
    Abstract: The present invention relates to pyrrolidones which are analogues of prostaglandins and to a process for their manufacture. The compounds of the invention have prostaglandin-like pharmacological properties and can therefore be used as pharmaceutical compositions.
    Type: Grant
    Filed: June 22, 1976
    Date of Patent: March 14, 1978
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dieter-Bernd Reuschling, Klaus Kuhlein, Bernward Scholkens, Rudolf Kunstmann, Ulrich Lerch, Wilhelm Bartmann, Hermann Teufel, Gerhard Beck
  • Cyclopentane derivatives and process for preparing them
    Patent number: 4061766
    Abstract: The present invention relates to cyclopentane derivatives similar to prostaglandins. Due to their antiprostaglandin effect they have valuable properties as medicaments.
    Type: Grant
    Filed: October 28, 1976
    Date of Patent: December 6, 1977
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wilhelm Bartmann, Rudolf Kunstmann, Ulrich Lerch, Bernward Scholkens
  • Peptides having an antihypertensive effect
    Patent number: 4013791
    Abstract: Novel peptide derivatives and a method of preparing the same are described. These compounds are useful in the diagnosis and treatment of hypertension.
    Type: Grant
    Filed: December 3, 1975
    Date of Patent: March 22, 1977
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans Wissmann, Rolf Geiger, Ernst Lindner, Bernward Scholkens