Patents by Inventor Bert O'Malley

Bert O'Malley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTRATUMORALLY ADMINISTERED LACTOFERRIN IN THE TREATMENT OF MALIGNANTNEOPLASMS AND OTHER HYPERPROLIFERATIVE DISEASES
    Publication number: 20100137208
    Abstract: The present invention relates to methods of treating a hyperproliferative disease by administering a composition of lactoferrin alone or in combination with standard anti-cancer therapies.
    Type: Application
    Filed: September 17, 2009
    Publication date: June 3, 2010
    Inventors: Atul Varadhachary, Rick Barsky, Karel Petrak, Bert O'Malley
  • Gene switch systems employing regulators with decreased dimerization
    Patent number: 7579326
    Abstract: Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: August 25, 2009
    Assignees: Genetronics, Inc., Baylor College of Medicine
    Inventors: Ronald V Abruzzese, Vidya Mehta, Jeffrey L Nordstrom, Jason Fewell, Bert O'Malley, Sophia Tsai
  • Adenoviral vector-mediated delivery of modified steroid hormone receptors and related products and methods
    Publication number: 20050196751
    Abstract: The present invention relates to adenoviral delivery of modified steroid hormone receptor proteins. The adenoviral vector preferably contains no viral coding sequence and is capable of accepting a large insert. Such vectors preferably are capable of achieving high levels and durations of delivery and expression. The modified protein preferably is capable of distinguishing a hormone agonist from an antagonist and may be modified in the ligand binding domain, the DNA binding domain, and/or the transregulatory domain.
    Type: Application
    Filed: May 18, 2001
    Publication date: September 8, 2005
    Inventors: Mark Burcin, Bert O'Malley, Gudrun Schiedner, Sophia Tsai, Stefan Kochanek
  • Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms
    Publication number: 20050064546
    Abstract: The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for lactoferrin protein. Methods for the production of lactoferrin protein in fungi and bacteria are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant lactoferrin protein and lactoferrin related polypeptides.
    Type: Application
    Filed: July 15, 2003
    Publication date: March 24, 2005
    Inventors: Orla Conneely, Denis Headon, Bert O'Malley, Gregory May
  • Intratumorally administered lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases
    Publication number: 20040082504
    Abstract: The present invention relates to methods of treating a hyperproliferative disease by administering a composition of lactoferrin alone or in combination with standard anti-cancer therapies.
    Type: Application
    Filed: May 9, 2003
    Publication date: April 29, 2004
    Inventors: Atul Varadhachary, Rick Barsky, Karel Petrak, Bert O'Malley
  • Steroid receptor coactivator compositions and methods of use
    Patent number: 6380373
    Abstract: The present invention relates to SRC-1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for enhancing and inhibiting transcription by providing SRC-1 polypeptides or fragments thereof to a cell.
    Type: Grant
    Filed: August 21, 1996
    Date of Patent: April 30, 2002
    Assignee: Baylor College of Medicine
    Inventors: Bert O'Malley, Ming-Jer Tsai, Sophia Y. Tsai, Sergio Onate