Abstract: Agents that bind to sarbecoviruses of multiple clades, neutralizing sarbecovirus infection, in particular neutralizing SARS-CoV-1 and SARS-CoV-2 infection. The agents bind to a unique epitope of the sarbecovirus ACE2-receptor binding domain (RBD) but do not inhibit binding of ACE2 with the RBD. Applications and uses of these agents are further disclosed.

Abstract: A pant-type absorbent article including an outer cover being disposed on a garment facing side of the absorbent article, the article having a front portion, a back portion and a crotch portion therebetween. The outer cover includes a nonwoven fibrous material on a garment-facing side thereof and a disposal tape including a tape adhesive zone is permanently attached at the tape adhesive zone to the outer cover in an attachment zone on the nonwoven fibrous material of the outer cover in the back portion of the article. The disposal tape has a folded pre-disposal configuration and an unfolded disposal configuration. The outer cover attachment zone is constituted by a modified portion of the nonwoven fibrous material, wherein a bond strength between the tape adhesive zone and the modified attachment zone is greater than a bond strength between the tape adhesive zone and a non-modified portion of the nonwoven fibrous material.