Patents by Inventor Bert W. O'Malley

Bert W. O'Malley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
    Patent number: 5766939
    Abstract: The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product.The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for lactoferrin protein. Methods for the production of lactoferrin protein in fungi and bacteria are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant lactoferrin protein and lactoferrin related polypeptides.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: June 16, 1998
    Assignee: Baylor College of Medicine
    Inventors: Orla M. Conneely, Denis R. Headon, Bert W. O'Malley, Gregory S. May
  • Method of identifying hormone antagonists and agonists
    Patent number: 5759785
    Abstract: The present invention provides a novel method of determining the antagonist and agonist activity of a compound for steroid hormone receptors. The present invention also provides a method of determining antagonist activity of a compound for a hormone receptor by inducing the conformational change in the receptor. In addition, the present invention provides a novel method of determining the level of agonist activity of a compound for steroid hormone receptors.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: June 2, 1998
    Assignee: Baylor College of Medicine
    Inventors: Ming-Jer Tsai, Bert W. O'Malley, Sophia Yang Tsai, George Francis Allan
  • Expression vector systems and method of use
    Patent number: 5756264
    Abstract: This invention relates to gene therapy by using vectors which encode stable MRNA and methods of using such vectors. In particular, this invention relates to vectors which establish controlled expression of recombinant genes within tissues at certain levels. The vector includes a 5' flanking region which includes necessary sequences for expression of a nucleic acid cassette, a 3' flanking region including a 3' UTR and/or 3' NCR which stabilizes mRNA expressed from the nucleic acid cassette, and a linker which connects the 5' flanking region to a nucleic acid sequence. The linker has a position for inserting a nucleic acid cassette. The linker does not contain the coding sequence of a gene that the linker is naturally associated with. The 3' flanking region is 3' to the position for inserting the nucleic acid cassette. The expression vectors of the present invention can also be regulated by a regulatory system and/or constructed with a coating.
    Type: Grant
    Filed: March 9, 1994
    Date of Patent: May 26, 1998
    Assignee: Baylor College of Medicine
    Inventors: Robert J. Schwartz, Franco J. DeMayo, Bert W. O'Malley
  • Production of recombinant human lactoferrin
    Patent number: 5571896
    Abstract: The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for human lactoferrin protein. Methods for the production of human lactoferrin protein in A. Oryzae are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant human lactoferrin protein.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: November 5, 1996
    Assignee: Baylor College of Medicine
    Inventors: Orla M. Conneely, Denis R. Headon, Bert W. O'Malley, Gregory S. May
  • Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus
    Patent number: 5571697
    Abstract: The subject invention provides for the production of lactoferrins and lactoferrin polypeptide fragments using the host cells Aspergillus in combination with novel plasmid constructs. More specifically, the subject invention provides novel vector constructs capable of producing lactoferrins and lactoferrin polypeptide fragments in Aspergillus host cells. More particularly, the subject invention provides for novel plasmid constructs suitable for use with Aspergillus and especially Aspergillus awamori, niger and oryzae host cells, which enables them to produce large amounts of recombinant lactoferrins and lactoferrin polypeptide fragments.
    Type: Grant
    Filed: November 2, 1994
    Date of Patent: November 5, 1996
    Assignee: Baylor College of Medicine Texas Medical Center
    Inventors: Orla M. Conneely, Denis R. Headon, Bert W. O'Malley
  • Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
    Patent number: 5571691
    Abstract: The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product.The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for lactoferrin protein. Methods for the production of lactoferrin protein in fungi and bacteria are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant lactoferrin protein and lactoferrin related polypeptides.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: November 5, 1996
    Assignee: Baylor College of Medicine
    Inventors: Orla M. Conneely, Denis R. Headon, Bert W. O'Malley, Gregory S. May
  • Progesterone receptor having C. terminal hormone binding domain truncations
    Patent number: 5364791
    Abstract: The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors.
    Type: Grant
    Filed: May 14, 1992
    Date of Patent: November 15, 1994
    Inventors: Elisabetta Vegeto, Donald P. McDonnell, Bert W. O'Malley
  • Myogenic vector systems
    Patent number: 5298422
    Abstract: The present invention includes a Myogenic vector system (MVS) for the expression of a nucleic acid sequence in myogenic tissue. The MVS contains a promoter, a cassette with the sequence of interest, a 3' untranslated region (3' UTR) and contiguous noncoding region (NCR). Further enhancements can include the addition of a leader sequence, intron sequence, initiation codon and specificThis invention was partially supported by a grant from the United States government under HL-38401 awarded by the National Institute of Health. The Government has certain rights in the invention.
    Type: Grant
    Filed: November 6, 1991
    Date of Patent: March 29, 1994
    Assignee: Baylor College of Medicine
    Inventors: Robert J. Schwartz, Franco J. DeMayo, Bert W. O'Malley