Patents by Inventor Bertfried Matz

Bertfried Matz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variants of hepatitis B virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof
    Patent number: 7807437
    Abstract: The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues both in vivo and in vitro. More in particular, reverse transcriptase mutant rt I233V is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring anti-viral therapeutic regimes and adjusting patient therapy. A diagnostic kit for detecting the presence of an HBV variant in a biological sample has also been described. Finally, the use of a pharmaceutical composition to cure a subject suffering from a HBV infection, which HBV is resistant to lamuvidine and/or adefovir has been provided, which pharmaceutical composition comprises the nucleoside analogue tenofovir.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: October 5, 2010
    Assignees: Rheinishche Friedrich-Wilhelms-Universitaet Bonn, Universitaet Zu Koeln, Justus-Liebig-Universitaet Gissen
    Inventors: Oliver Schildgen, Martin Vogel, Bertfried Matz, Juergen Rockstroh, Rolf Kaiser, Martin Daeumer, Martin Helm, Lutwin Weitner, Carl Knud Schewe, Wolfram Gerlich
  • Variants of hepatitis B virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof
    Publication number: 20070042356
    Abstract: The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues both in vivo and in vitro. More in particular, reverse transcriptase mutant rt I233V is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring anti-viral therapeutic regimes and adjusting patient therapy. A diagnostic kit for detecting the presence of an HBV variant in a biological sample has also been described. Finally, the use of a farmaceutical composition to cure a subject suffering from a HBV infection, which HBV is resistant to lamuvidine and/or adefovir has been provided, which farmaceutical composition comprises the nucleoside analogue tenofovir.
    Type: Application
    Filed: March 15, 2006
    Publication date: February 22, 2007
    Applicants: Rheinische Friedrich-Wilhelms-Universitaet Bonn, Universitaet zu Koeln, Justus-Liebig-Universitaet Giessen
    Inventors: Oliver Schildgen, Martin Vogel, Bertfried Matz, Juergen Rockstroh, Rolf Kaiser, Martin Daeumer, Martin Helm, Lutwin Weitner, Carl Schewe, Wolfram Gerlich