Abstract: The invention provides an extended-release dosage form of cyclobenzaprine for use in the treatment of tinnitus and related auditory dysfunctions by once-a-day oral administration, wherein the dosage form is a tablet or capsule comprising cyclobenzaprine as active agent in an amount from 10-80 mg, preferably from 10-60 mg. The active agent is associated with a polymer coating or matrix that comprises a water-insoluble polymer, the polymer coating or matrix providing the dosage form with an extended release of the active agent over at least 12 hours and preferably over at least 16 hours when the dosage form is administered to a patient.

Abstract: The invention provides cyclobenzaprine for use in the treatment of tinnitus and related auditory dysfunctions by oral administration as tablets, capsules, powder or a solution or by parenteral administration of cyclobenzaprine through intramuscular, intravenous, subcutaneous or intrathecal injection, or infusion, preferably in an amount from 15 to 45 mg/day, preferably in a long-term treatment over 2 or 8 weeks or more.

Abstract: A method for planning the stimulation of hyper/hypometabolic cortical areas includes determining anatomical patient data using an imaging method and detecting positions of (i) the hyper/hypometabolic cortical areas in a patient's anatomy and (ii) a position of a stimulator. The positions of the hyper/hypometabolic cortical areas are registered and/or referenced with respect to the position of the stimulation means. An optimal positioning for the stimulator is determined on the basis of the relative positional information.

Abstract: A method for planning the stimulation of hyper/hypometabolic cortical areas includes determining anatomical patient data using an imaging method and detecting positions of (i) the hyper/hypometabolic cortical areas in a patient's anatomy and (ii) a position of a stimulator. The positions of the hyper/hypometabolic cortical areas are registered and/or referenced with respect to the position of the stimulation means. An optimal positioning for the stimulator is determined on the basis of the relative positional information.