Patents by Inventor Berthold Richard Vogt

Berthold Richard Vogt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4115555
    Abstract: Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, and trifluoromethyl, and R is selected from a triacetyl substituted pentose, pentose, a tetraacetyl substituted hexose, hexose, a hydroxy substituted cycloalkyl of 5 to 7 carbons, ##STR2## wherein n is 1 or 2 ad R.sup.3 is hydrogen, an alkali metal or alkaline earth metal ion; are disclosed. These compounds possess useful anti-inflammatory activity.
    Type: Grant
    Filed: July 5, 1977
    Date of Patent: September 19, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 4111940
    Abstract: Various 1,5,6,11-tetrahydrobenzo[5,6]cyclohepta[1,2-b]-pyrazolo[4,3-e]pyridine derivatives and their salts of the formulas ##STR1## wherein R.sub.1 is lower alkyl, phenyl, or phenyl-lower alkyl; R.sub.2 is hydrogen, lower alkyl or phenyl; R.sub.3 is hydrogen, halogen, or lower alkoxy; R.sub.4 is hydrogen, ##STR2## ALKYL; R.sub.5 is hydrogen or lower alkoxy; R.sub.6 is hydrogen, ##STR3## n is an integer from 2 to 6; R.sub.7 and R.sub.8 are the same or different and each is lower alkyl or R.sub.7 and R.sub.8 taken together with the N-atom form a heterocyclic ring of the formula ##STR4## wherein R.sub.9 is hydrogen or lower alkyl; R.sub.10 and R.sub.11 are the same or different and each is hydrogen or lower alkyl or R.sub.10 and R.sub.11 taken together with the N-atom form a heterocyclic ring of the formula ##STR5## wherein R.sub.9 is as defined above; are disclosed. These compounds possess useful antiinflammatory activity as well as psychotropic activity.
    Type: Grant
    Filed: April 7, 1977
    Date of Patent: September 5, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hans Hoehn, Jack Bernstein, Berthold Richard Vogt
  • Patent number: 4087433
    Abstract: Compounds of the formulas ##STR1## wherein R.sub.1 is lower alkyl, phenyl, benzyl or phenethyl; R.sub.2 is hydrogen, lower alkyl or phenyl; R is ##STR2## N IS AN INTEGER FROM 3 TO 6; R.sub.3 and R.sub.4 are each lower alkyl or R.sub.3 and R.sub.4 taken together with the N-atom form a heterocyclic ring of the formula ##STR3## wherein R.sub.5 is hydrogen, lower alkyl, or lower alkoxy; and pharmaceutically acceptable acid addition salts thereof are disclosed. These compounds and their salts possess central nervous system activity and are useful as anti-anxiety agents.
    Type: Grant
    Filed: March 28, 1977
    Date of Patent: May 2, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hans Hoehn, Jack Bernstein, Berthold Richard Vogt
  • Patent number: 4077958
    Abstract: Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, nitro, amino and cyano; Z is selected from ##STR2## R.sup.3 is selected from phenyl, phenyl-lower alkyl, substituted phenyl, and substituted phenyl-lower alkyl; R.sup.4 is selected from R.sup.3 and a 6-membered unsaturated substituted or unsubstituted heterocyclic ring selected from pyridine, diazine and triazine; and A is a straight or branched chain alkylene of 2 to 8 carbons are disclosed. These compounds exhibit antidepressant activity.
    Type: Grant
    Filed: August 27, 1976
    Date of Patent: March 7, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 4070465
    Abstract: Compounds of the following formula and their acid addition salts ##STR1## Z is ##STR2## A is straight or branched chain alkylene of 2 to 6 carbons; B is straight chain alkylene of 2 to 4 carbons; X is straight or branched chain alkyl of 1 to 8 carbons, phenyl, benzyl, phenethyl, substituted phenyl, substituted benzyl, or substituted phenethyl, R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons, straight or branched chain alkoxy of 1 to 4 carbons, Cl, Br, F, amino, nitro, CF.sub.3, and cyano; are disclosed. These compounds possess antiprotozoal activity.
    Type: Grant
    Filed: June 24, 1976
    Date of Patent: January 24, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 4062953
    Abstract: Compounds of the following formula and their acid addition salts ##STR1## A is straight or branched chain alkylene of 2 to 6 carbons; R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons, straight or branched chain alkoxy of 1 to 4 carbons, Cl, Br, F, amino, nitro, cyano, and CF.sub.3 ; R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen and straight or branched chain alkyl of 1 to 4 carbons; and n is 1, 2, or 3; m is 1 or 2; are disclosed. These compounds possess anti-protozoal activity.
    Type: Grant
    Filed: June 24, 1976
    Date of Patent: December 13, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 4051246
    Abstract: Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, and trifluoromethyl, and R is selected from a triacetyl substituted pentose, pentose, a tetraacetyl substituted hexose, hexose, a hydroxy substituted cycloalkyl of 5 to 7 carbons, ##STR2## wherein n is 1 or 2 and R.sup.3 is hydrogen, an alkali metal or alkaline earth metal ion; are disclosed. These compounds possess useful anti-inflammatory activity.
    Type: Grant
    Filed: September 29, 1976
    Date of Patent: September 27, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 4033970
    Abstract: Compounds of the formulas wherein R.sub.1 is lower alkyl, phenyl, benzyl or phenethyl; R.sub.2 is hydrogen, lower alkyl or phenyl; R is ##STR1## N IS AN INTEGER FROM 3 TO 6; R.sub.3 and R.sub.4 are each lower alkyl or R.sub.3 and R.sub.4 taken together with the N-atom form a heterocyclic ring of the formula ##STR2## wherein R.sub.5 is hydrogen, lower alkyl, or lower alkoxy; and pharmaceutically acceptable acid addition salts thereof are disclosed. These compounds and their salts possess central nervous system activity and are useful as anti-anxiety agents.
    Type: Grant
    Filed: June 23, 1976
    Date of Patent: July 5, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hans Hoehn, Jack Bernstein, Berthold Richard Vogt
  • Patent number: 4020064
    Abstract: Compounds of the following formula and their pharmaceutically acceptable salts ##STR1## wherein R.sub.1 and R.sub.4 are the same or different and are each a five or six membered N containing heterocycle attached at an available N atom; R.sub.2 is hydrogen, alkyl, trifluoromethyl, phenyl, benzyl, --(CH.sub.2).sub.n --R.sub.4 or --(CH.sub.2).sub.n --N(alkyl).sub.2 ; R.sub.3 is hydrogen, halogen, nitro, trifluoromethyl, alkyl, alkoxy, or alkylthio; and n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-inflammatory agents.
    Type: Grant
    Filed: April 26, 1976
    Date of Patent: April 26, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 4007191
    Abstract: Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, nitro, amino and cyano; Z is selected from ##STR2## R.sup.3 is selected from phenyl, phenyl-lower alkyl, substituted phenyl, and substituted phenyl-lower alkyl; R.sup.4 is selected from R.sup.3 and a 6-membered unsaturated substituted or unsubstituted heterocyclic ring selected from pyridine, diazine and triazine; and A is a straight or branched chain alkylene of 2 to 8 carbons are disclosed. These compounds exhibit antidepressant activity.
    Type: Grant
    Filed: October 14, 1975
    Date of Patent: February 8, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 4002639
    Abstract: Compounds of the following formula ##STR1## wherein W is O or S; and X, Y and Z are independently selected from hydrogen, fluorine, bromine, chlorine, trifluoromethyl, lower alkyl and lower alkoxy; are disclosed. These compounds are useful as antiinflammatory agents.
    Type: Grant
    Filed: March 31, 1975
    Date of Patent: January 11, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Berthold Richard Vogt
  • Patent number: 3996362
    Abstract: Compounds of the following formula and their acid addition salts ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, amino, trifluoromethyl, or cyano; R.sup.3 is hydrogen or lower alkyl; R.sup.4 and R.sup.5 are selected from hydrogen, halogen, lower alkyl, or lower alkoxy; the dashed line indicates the optional presence of a double bond; and A is straight or branched chain alkylene of 1-8 carbons; are disclosed. These compounds exhibit antidepressant activity. In addition, these compounds are useful as antiinflammatory agents.
    Type: Grant
    Filed: May 28, 1975
    Date of Patent: December 7, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3996363
    Abstract: Compounds of the following formula and their acid addition salts ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, amino, nitro and cyano; R.sup.3 is hydrogen, lower alkyl or lower alkenyl; R.sup.4 is hydrogen, halogen, or lower alkyl; and A is straight or branched chain alkylene are disclosed. These compounds exhibit antidepressant activity. In addition, these compounds are useful as antiinflammatory agents.
    Type: Grant
    Filed: June 13, 1975
    Date of Patent: December 7, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3985731
    Abstract: A compound of the formula ##SPC1##Wherein X and R are as defined hereinafter, at least one of X and R being other than hydrogen, are provided and which are useful as central nervous system stimulants and for inducing increased motor activity as well as in vitro antimicrobial agents.
    Type: Grant
    Filed: March 28, 1975
    Date of Patent: October 12, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Berthold Richard Vogt
  • Patent number: 3969366
    Abstract: Compounds of the following formula and their pharmaceutically acceptable salts ##SPC1##Wherein R.sub.1 and R.sub.4 are the same or different and are each a five or six membered N containing heterocycle attached at an available N atom; R.sub.2 is hydrogen, alkyl, trifluoromethyl, phenyl, benzyl, --(CH.sub.2).sub.n --R.sub.4 or --(CH.sub.2).sub.n --N(alkyl).sub.2 ; R.sub.3 is hydrogen, halogen, nitro, trifluoromethyl, alkyl, alkoxy, or alkylthio; and n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-inflammatory agents.
    Type: Grant
    Filed: May 30, 1975
    Date of Patent: July 13, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3959286
    Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; R.sup.3 is phenyl or substituted phenyl; and R is lower alkyl or cycloalkyl of 3 to 7 carbons are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are useful as antiinflammatory agents.
    Type: Grant
    Filed: January 6, 1975
    Date of Patent: May 25, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3947452
    Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and m is 1 or 2 are disclosed. These compounds exhibit antidepressant and anti-anxiety activity. In addition these compounds are useful as antiinflammatory agents.
    Type: Grant
    Filed: January 6, 1975
    Date of Patent: March 30, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3940397
    Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and Z is ##SPC2##Wherein R.sup.3 is selected from phenyl, phenyl-lower alkyl, and substituted phenyl and phenyl-lower alkyl are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are useful as antiinflammatory agents.
    Type: Grant
    Filed: November 13, 1974
    Date of Patent: February 24, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3940398
    Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and R is a 6-membered unsaturated substituted or unsubstituted heterocyclic ring selected from pyridine, diazine and triazine are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are also useful as antiinflammatory agents.
    Type: Grant
    Filed: January 23, 1975
    Date of Patent: February 24, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3935227
    Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and Z is selected from ##SPC2##Wherein R.sup.3 is selected from phenyl, phenyl-lower alkyl, and substituted phenyl and phenyl-lower alkyl are disclosed. These compounds exhibit antidepressant and anti-anxiety activity. In addition these compounds are useful as anti-inflammatory agents.
    Type: Grant
    Filed: August 28, 1974
    Date of Patent: January 27, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt