Patents by Inventor Bertil Hogberg

Bertil Hogberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel 17-esters of 17.alpha.-hydroxy gestogens, compositions containing such compounds, processes for their preparation and methods of treatment therewith
    Patent number: 4177269
    Abstract: This invention relates to novel 17.alpha.-esters of gestogens having an antitumour activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and method of treatment therewith.
    Type: Grant
    Filed: January 17, 1977
    Date of Patent: December 4, 1979
    Assignee: Aktiebolaget Leo
    Inventors: Hans Fex, Bertil Hansen, Krister Holmberg, Bertil Hogberg, Imre Konyves
  • Novel enol esters of steroids, compositions containing such compounds, processes for their preparation and methods of treatment therewith
    Patent number: 4150126
    Abstract: This invention relates to novel enol esters of steroids having an antitumor activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds and methods of treatment therewith.
    Type: Grant
    Filed: January 17, 1977
    Date of Patent: April 17, 1979
    Assignee: Aktiebolaget Leo
    Inventors: Hans Fex, Bertil Hansen, Krister Holmberg, Bertil Hogberg, Imre Konyves
  • Novel compounds, compositions containing such compounds, processes for their preparation and methods of treatment
    Patent number: 4055638
    Abstract: This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith.The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3',5'-monophosphate (cyclic AMP).In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.
    Type: Grant
    Filed: July 23, 1976
    Date of Patent: October 25, 1977
    Assignee: Aktiebolaget Leo
    Inventors: Bertil Hogberg, Hans Fex, Torsten Perklev, Sten Veige, Bo Fredholm
  • Method, composition and compounds for treating excess prostaglandins
    Patent number: 4049800
    Abstract: This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith.The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3',5'-monophosphate (cyclic AMP).In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.
    Type: Grant
    Filed: August 20, 1976
    Date of Patent: September 20, 1977
    Assignee: Aktiebolaget Leo
    Inventors: Bertil Hogberg, Hans Fex, Torsten Perklev, Sten Veige, Bo Fredholm
  • Method, composition and compounds for treating excess prostaglandins
    Patent number: 4049799
    Abstract: This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith.The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3',5'-monophosphate (cyclic AMP).In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.
    Type: Grant
    Filed: August 20, 1976
    Date of Patent: September 20, 1977
    Assignee: Aktiebolaget Leo
    Inventors: Bertil Hogberg, Hans Fex, Torsten Perklev, Sten Veige, Bo Fredholm
  • Cortical steroid nitrogen mustard compositions and treatment therewith
    Patent number: 4029778
    Abstract: New 21-esters of corticoid steroid hormones, the esters having an antitumor activity, are prepared by reacting a reactive derivative of the general formula ##STR1## wherein R.sup.1 can be hydrogen, lower alkyl, halogen, or lower alkoxy, X can be oxygen, sulphur, or a monovalent carbon-to-carbon bond, A can be alkylene, aminoalkylene, or lower-alkanoyl aminoalkylene, and A together with X also can be a monovalent carbon-to-carbon bond, with a corticoid steroid.
    Type: Grant
    Filed: March 13, 1973
    Date of Patent: June 14, 1977
    Assignee: Aktiebolaget Leo
    Inventors: Hans Jacob Fex, Knut Bertil Hogberg, Imre Konyves
  • Secondary phosphoric acid esters, composition and method of use
    Patent number: 3995033
    Abstract: This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith.The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3',5'-monophosphate (cyclic AMP).In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.
    Type: Grant
    Filed: October 31, 1974
    Date of Patent: November 30, 1976
    Assignee: Aktiebolaget Leo
    Inventors: Bertil Hogberg, Hans Fex, Torsten Perklev, Sten Veige, Bo Fredholm
  • Medicinal compositions and methods of use involving phosphoric acid esters
    Patent number: 3991187
    Abstract: Novel symmetrical secondary phosphoric acid esters having the general formula ##SPC1##Wherein the substituent R is positioned in meta or para position relative to the phosphoric acid ester group; processes for the preparation of said esters; and compositions containing said esters. The esters are i.a. useful as selective inhibitors of prostaglandins and compounds with prostaglandin activities. They also selectively antagonize the slow reacting substance (SRS).
    Type: Grant
    Filed: May 6, 1974
    Date of Patent: November 9, 1976
    Assignee: Aktiebolaget Leo
    Inventors: Knut Bertil Hogberg, Hans Jacob Fex, B. Goran Fredholm, Torsten Rune Perklev, Sten Gunnar Veige
  • Secondary phosphoric acid esters
    Patent number: 3989825
    Abstract: This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith.The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3' ,5'-monophosphate (cyclic AMP).In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.
    Type: Grant
    Filed: August 14, 1972
    Date of Patent: November 2, 1976
    Assignee: Aktiebolaget Leo
    Inventors: Bertil Hogberg, Hans Fex, Torsten Perklev, Sten Veige, Bo Fredholm
  • Novel N-nitroso compounds, compositions containing such compounds, processes for their preparation and methods of treatment therewith, and novel intermediates
    Patent number: 3963707
    Abstract: This invention relates to novel N-halogenoalkyl-N-nitroso carbamates and N.sup.4 halogenalkyl-N.sup.4 -nitroso allophanates of steroid compounds, having an anti-tumor activity, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith.
    Type: Grant
    Filed: February 25, 1974
    Date of Patent: June 15, 1976
    Assignee: Aktiebolaget Leo
    Inventors: Knut Bertil Hogberg, Hans Jacob Fex, Imre Konyves, Anders Robert Stamvik
  • Certain steroid N-bis-(haloethyl)-carbamates
    Patent number: RE29199
    Abstract: .Iadd.Antitumor active mono and poly N-Bis-(B-haloethyl)-carbamic acid esters of certain estrogenic steroid hormones, especially estradiol; such compounds wherein all hydroxyl groups of the steroid molecule are not thus esterified; and organic and inorganic acid esters of such latter compounds. .Iaddend.
    Type: Grant
    Filed: July 30, 1976
    Date of Patent: May 3, 1977
    Assignee: Aktiebolaget Leo
    Inventors: Hans Jakob Fex, Knut Bertil Hogberg, Imre Konyves, Paul Hans Otto Joseph Kneip
  • Secondary phosphoric acid esters
    Patent number: RE29202
    Abstract: Novel symmetrical secondary phosphoric acid esters having the general formula ##STR1## wherein the substituent R is positioned in meta or para position relative to the phosphoric acid ester group; processes for the preparation of said esters; and compositions containing said esters. The esters are i.a. useful as selective inhibitors of prostaglandins and compounds with prostaglandin activities. They also selectively antagonize the slow reacting substance (SRS).
    Type: Grant
    Filed: August 4, 1976
    Date of Patent: May 3, 1977
    Assignee: Aktiebolaget Leo
    Inventors: Knut Bertil Hogberg, Hans Jacob Fex, Bo Goran Fredholm, Torsten Rune Perklev, Sten Gunnar Veige