Patents by Inventor Berton Zbar

Berton Zbar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION OF A NOVEL BHD GENE
    Publication number: 20150045307
    Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and methods of using the nucleic acids and proteins encoded thereby. In particular, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, and methods of treating BHD skin lesions.
    Type: Application
    Filed: October 21, 2014
    Publication date: February 12, 2015
    Applicant: The Government of the United States of America as represented by the Secretary of the Department of
    Inventors: Laura S. Schmidt, Michelle B. Warren, Jorge R. Toro, Berton Zbar, Michael L. Nickerson, W. Marston Linehan, Maria L. Turner
  • Identification of a novel BHD gene
    Patent number: 8865880
    Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and methods of using the nucleic acids and proteins encoded thereby. In particular, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, and methods of treating BHD skin lesions.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: October 21, 2014
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Laura S. Schmidt, Michelle Warren, Jorge R. Toro, Berton Zbar, Michael L. Nickerson, Marston W. Linehan, Maria L. Turner
  • IDENTIFICATION OF A NOVEL BHD GENE
    Publication number: 20110288031
    Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and methods of using the nucleic acids and proteins encoded thereby. In particular, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, and methods of treating BHD skin lesions.
    Type: Application
    Filed: July 11, 2011
    Publication date: November 24, 2011
    Inventors: Laura S. Schmidt, Michelle Warren, Jorge R. Toro, Berton Zbar, Michael L. Nickerson, W. Marston Linehan, Maria L. Turner
  • Folliculin-specific antibodies and methods of detection
    Patent number: 8003764
    Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and antibodies that specifically bind to the BHD protein (folliculin). In addition, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, by detection of altered expression of folliculin using folliculin-specific antibodies.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: August 23, 2011
    Assignee: United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Laura S. Schmidt, Michelle Warren, Jorge R. Toro, Berton Zbar, Michael L. Nickerson, W. Marston Linehan, Maria L. Turner
  • IDENTIFICATION OF A NOVEL BHD GENE
    Publication number: 20090192086
    Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and methods of using the nucleic acids and proteins encoded thereby. In particular, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, and methods of treating BHD skin lesions.
    Type: Application
    Filed: December 12, 2008
    Publication date: July 30, 2009
    Inventors: Laura S. Schmidt, Michelle Warren, Jorge R. Toro, Berton Zbar, Michael L. Nickerson, W. Marston Linehan, Maria L. Turner
  • Identification of a novel BHD gene
    Patent number: 7485709
    Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and methods of using the nucleic acids and proteins encoded thereby. In particular, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, and methods of treating BHD skin lesions.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: February 3, 2009
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Laura S. Schmidt, Michelle Warren, Jorge P. Toro, Berton Zbar, Michael L. Nickerson, W. Marston Linehan, Maria L. Turner
  • Identification of a novel bhd gene
    Publication number: 20050170357
    Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and methods of using the nucleic acids and proteins encoded thereby. In particular, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, and methods of treating BHD skin lesions.
    Type: Application
    Filed: May 30, 2003
    Publication date: August 4, 2005
    Inventors: Laura Schmidt, Michelle Warren, Jorge Toro, Berton Zbar, Michael Nickerson, W. Lenehan, Maria Turner
  • Partial intron sequence of von hippel-lindau (VHL) disease gene and its use in diagnosis of disease
    Patent number: 6312890
    Abstract: The Von Hippel-Lindau (VHL) disease gene and its corresponding cDNA are disclosed. Methods for detecting carriers of the VHL disease gene using probes derived from the VHL disease gene sequence are described. Pharmaceutical compositions and methods of treating diseases related to the VHL gene are also disclosed.
    Type: Grant
    Filed: March 28, 1996
    Date of Patent: November 6, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: W. Marston Linehan, Michael I. Lerman, Farida Latif, Berton Zbar
  • Von Hippel - Lindau (VHL) disease gene and corresponding cDNA and methods for detecting carriers of the VHL disease gene
    Patent number: 5759790
    Abstract: The invention is the Von Hippel-Lindau (VHL) disease gene and its corresponding cDNA protein product, and antibodies therefore. Methods for detecting carriers of the VHL disease gene using probes derived from the cDNAs are described. Antibodies and methods of detecting the Von-Hippel-Lindau protein are also described.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 2, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael I. Lerman, Farida Latif, Berton Zbar, Marston Linehan
  • Von hippel-lindau (VHL) disease gene and corresponding cDNA and methods for detecting carriers of the VHL disease gene
    Patent number: 5654138
    Abstract: The invention is the Yon Hippel-Lindau (VHL) disease gene and its corresponding cDNA. Methods for detecting carriers of the VHL disease gene using probes derived from the cDNAs are described.
    Type: Grant
    Filed: May 14, 1993
    Date of Patent: August 5, 1997
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Michael I. Lerman, Farida Latif, Berton Zbar, Marston Linehan
  • Model for von Hippel-Lindau disease
    Patent number: H2056
    Abstract: Disclosed herein are nucleic acid molecules that can be used to effect a loss of function of the von Hippel-Lindau (VHL) allele in somatic and/or germ cells of a mammal and methods for using these molecules to create conditional VHL gene targeted and conditional VHL knockout animals. Disclosed herein are conditional VHL gene target vectors which, when inserted into an endogenous VHL gene, can result in deletion of an exon of a VHL gene by site-specific recombinaton when a recombinase is expressed conditionally.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: December 3, 2002
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Laura S. Schmidt, Wenbin Ma, Lino Tessarollo, Berton Zbar