Abstract: The oral cavity is a source of sensitive biomarkers that allow the development of novel tobacco filters to reverse and eliminate acute adverse effects of tobacco smoke. Useful biomarkers are ubiquitous functional leukocytes and associated essential biochemical mechanisms, including metabolic pathways and specific enzymes, such as myeloperoxidase contained in fluid-cell lavages obtained from the human mouth. These biomarkers derived from the human mouth and sputum from the human respiratory system can be used to evaluate long-term chronic effects of tobacco smoke. A tobacco filter comprising strongly basic anion exchange resins and strongly acidic cation exchange resins with or without activated carbon, is used to detect, reduce and eliminate toxic substances from tobacco smoke while retaining taste and aroma. The novel filter in conjunction with biomarkers allow the establishment of performance standards that permit the direct visualization and measurement of acute adverse reactions caused by tobacco smoke.

Abstract: The oral cavity is a source of sensitive biomarkers that allow the development of novel tobacco filters to reverse and eliminate acute adverse effects of tobacco smoke. Useful biomarkers are ubiquitous functional leukocytes and associated essential biochemical mechanisms, including metabolic pathways and specific enzymes, such as myeloperoxidase contained in fluid-cell lavages obtained from the human mouth. These biomarkers derived from the human mouth and sputum from the human respiratory system can be used to evaluate long-term chronic effects of tobacco smoke. A tobacco filter comprising strongly basic anion exchange resins and strongly acidic cation exchange resins with or without activated carbon, is used to detect, reduce and eliminate toxic substances from tobacco smoke while retaining taste and aroma. The novel filter in conjunction with biomarkers allow the establishment of performance standards that permit the direct visualization and measurement of acute adverse reactions caused by tobacco smoke.

Abstract: The oral cavity is a source of sensitive biomarkers that allow the development of novel tobacco filters to reverse and eliminate acute adverse effects of tobacco smoke. Useful biomarkers are ubiquitous functional leukocytes and associated essential biochemical mechanisms, including metabolic pathways and specific enzymes, such as myeloperoxidase contained in fluid-cell lavages obtained from the human mouth. These biomarkers derived from the human mouth and sputum from the human respiratory system can be used to evaluate long-term chronic effects of tobacco smoke. A tobacco filter comprising strongly basic anion exchange resins and strongly acidic cation exchange resins with or without activated carbon, is used to detect, reduce and eliminate toxic substances from tobacco smoke while retaining taste and aroma. The novel filter in conjunction with biomarkers allow the establishment of performance standards that permit the direct visualization and measurement of acute adverse reactions caused by tobacco smoke.

Abstract: Novel compositions for establishing environmental conditions in the human oral cavity for maintaining healthy, functional oral leucocytes, said compositions comprising a non-toxic mixture of effective amounts of: (1) at least one compound for maintaining a colloidal and viscous environment within the oral cavity which favors and promotes oral leucocyte locomotion, phagocytosis and bacterial kill; (2) at least one compound providing and maintaining a balanced ionic environment which favors and promotes locomotion, phagocytosis and bacterial kill; (3) at least one compound providing a source of energy for said oral leucocytes; and (4) at least one compound for maintaining substantially a physiological pH to promote leucocyte functions while avoiding other tissue and cell injury; and novel products and processes employing the same.