Patents by Inventor Bertram L. Jacobs

Bertram L. Jacobs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inhibiting pathogenicity of infectious agents
    Patent number: 7001718
    Abstract: The present invention relates to methods of detecting or identifying inhibitors of a Z-DNA binding ligand to Z-DNA, methods of inhibiting the pathogenicity of an infectious agent, antiviral therapies, and compounds that inhibit complex formation between a Z-DNA binding ligand and Z-DNA.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: February 21, 2006
    Assignees: Massachusetts Institute of Technology, Arizona Board of Regents
    Inventors: Bertram L. Jacobs, Alexander Rich
  • Viral vectors having reduced virulence
    Patent number: 6750043
    Abstract: The present invention provides recombinant vaccinia virus having a deletion of the region encoding the C-terminal seven amino acids of the E3L gene product and comprising exogenous DNA. Compositions comprising the recombinant vaccinia virus and methods of use thereof are also provided.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: June 15, 2004
    Assignee: Arizona Board of Regents
    Inventors: Bertram L. Jacobs, Jeffrey O. Langland, Sangeetha Vijaysri, Teresa A. Brandt
  • Method of inhibiting pathogenicity of infectious agents
    Publication number: 20030211964
    Abstract: The present invention relates to methods of detecting or identifying inhibitors of a Z-DNA binding ligand to Z-DNA, methods of inhibiting the pathogenicity of an infectious agent, antiviral therapies, and compounds that inhibit complex formation between a Z-DNA binding ligand and Z-DNA.
    Type: Application
    Filed: December 16, 2002
    Publication date: November 13, 2003
    Applicants: Massachusetts Institute of Technology, Arizona Board of Regents
    Inventors: Bertram L. Jacobs, Alexander Rich
  • Vectors having enhanced expression, and methods of making and uses thereof
    Patent number: 6004777
    Abstract: Disclosed and claimed are vectors having enhanced expression and methods for making and using them. Enhancement of expression is from substantially co-temporal expression of at least one first nucleic acid molecule and at least one second nucleic acid molecule. The second nucleic acid molecule encodes a translation factor. The contemporaneous expression can be from operably linking the first and second nucleic molecules to a single promoter, or from operably linking the first nucleic acid molecule to a first promoter and the second nucleic molecule to a second promoter wherein the first and second promoters function substantially contemporaneously. Thus, the first and second nucleic acid molecules can be at the same locus in the vector or at different loci. The second nucleic acid molecule can encode encode one translation factor or more than one translation factor.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: December 21, 1999
    Assignees: Virogenetics Corporation, Arizona State University
    Inventors: James Tartaglia, Bertram L. Jacobs, Scott J. Goebel, William I. Cox, Russell Robert Gettig, Steven E. Pincus, Enzo Paoletti