Abstract: A moulded plastics bottle for sterile liquids comprising(a) a threaded neck, the neck having a frangible annular portion above the threaded portion and also having an integral seal moulded onto the neck to close the bottle, and(b) a cap having a thread complementary with the thread of the neck, the cap containing an internal annular ring comprising at least two inwardly directed fingers which engage with the downward facing edge of the annular portion of the neck, whereby unscrewing of the cap causes upward movement of the fingers so that the frangible portion is broken and the seal is removed to reveal the contents of the bottle.